DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8738 and CG8586

DIOPT Version :9

Sequence 1:	NP_610403.1	Gene:	CG8738 / 35855	FlyBaseID:	FBgn0033321	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_001286204.1	Gene:	CG8586 / 35854	FlyBaseID:	FBgn0033320	Length:	444	Species:	Drosophila melanogaster

Alignment Length:	454	Identity:	206/454 - (45%)
Similarity:	284/454 - (62%)	Gaps:	27/454 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLISLALISLAPAILSIRTCGSHEVCVSKKKCDESDDSGKGKLVKRILDNSCGRDLECCDREQLE 71
            ||:||...|:....:| ..|.|.|.|.|.|:|::|||||:..:..| ....||....||::.||:
  Fly    10 LLLSLCAFSMGQDTIS-AMCLSDERCTSLKRCEDSDDSGRRGIRPR-SSRICGTQRVCCEKAQLD 72

  Fly    72 NFEAYQAEIEYRNQRRKNIWASSDNPLEG--EPKPNLVGAKEDEPGYKSCGVKRECVPRHLCSTG 134
            :::.:..|      |...:.::..|.:..  ||.||           :|||...|||||.||...
  Fly    73 SYDRWLVE------RTTTVPSTIRNKVSSVLEPPPN-----------ESCGQNMECVPRKLCRDN 120

  Fly   135 VVNEDGRYIIKPRINEESNFGC-RVVEECCPLGDQIEEGRNPIQRNVKDFLLKGCGYSNPKGLYY 198
            ::|:.|..:|.|||   |...| :.:..||.:..::::..:|......:|..|.|||||||||..
  Fly   121 IINDSGISLINPRI---SPIQCSKSLYRCCAVDQKVDDSESPYLVKQANFKYKNCGYSNPKGLIP 182

  Fly   199 QLD--GYNNGESVFAEFPWMVALMDMEGNFVCGGTLIHPQLVLTSAHNVFNRSEDSLLVRAGDWD 261
            ..|  .|:...|:|.||||||.:......|:||||||||:||:|::||:.|.:.|:|:.||||||
  Fly   183 DNDKFPYSEDVSIFGEFPWMVGIFTGRQEFLCGGTLIHPRLVVTTSHNLVNETVDTLVARAGDWD 247

  Fly   262 LNSQTELHPYQMRAISELHRHENFNNLTLYNDIALVVLERPFQVAPHIQPICLPPPETPQMEAEL 326
            |||..|.:|:|...|.|:..|..|:..:|||||||::|:.|.::||||||:||||||:|::..:|
  Fly   248 LNSLNEPYPHQGSRIKEIIMHSEFDPNSLYNDIALLLLDEPIRLAPHIQPLCLPPPESPELTNQL 312

  Fly   327 RSASCLATGWGLRYSTSRTMENLLKRIELPAVDHESCQRLLRHTVLGRRYNLHPSFTCAGGVKGK 391
            .|.:|.|||||.:.:.|..:|::||||.||.|:.|.||..||:|.|..|:.|.|||.||||..||
  Fly   313 LSVTCYATGWGTKEAGSDKLEHVLKRINLPLVEREECQAKLRNTRLEARFRLRPSFICAGGDPGK 377

  Fly   392 DTCMGDGGSPLFCTLPGQKDRYQLVGLVSWGIECAEKDVPAAYTNVAYLRNWIDEQVTKSGFPL 455
            |||.|||||||||.:||:.|||||||:||||:|||.:|:||.|.||.:||.||||::...|..|
  Fly   378 DTCKGDGGSPLFCQMPGEMDRYQLVGIVSWGVECAVEDIPAVYVNVPHLRGWIDEKIRGLGIVL 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8738	NP_610403.1	Tryp_SPc	207..447	CDD:238113	137/239 (57%)
CG8738	NP_610403.1	Tryp_SPc	207..444	CDD:214473	134/236 (57%)
CG8586	NP_001286204.1	Tryp_SPc	197..433	CDD:238113	135/235 (57%)
CG8586	NP_001286204.1	Tryp_SPc	197..430	CDD:214473	132/232 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443426
Domainoid	1	1.000	162	1.000	Domainoid score	I3893
eggNOG	1	0.900	-	-		E33208_3BM7R
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	132	1.000	Inparanoid score	I4490
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23222at50557
OrthoFinder	1	1.000	-	-		FOG0003848
OrthoInspector	1	1.000	-	-		mtm8716
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24256
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900