DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8738 and prss60.3

DIOPT Version :9

Sequence 1:	NP_610403.1	Gene:	CG8738 / 35855	FlyBaseID:	FBgn0033321	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	XP_002662541.2	Gene:	prss60.3 / 335152	ZFINID:	ZDB-GENE-030131-7092	Length:	330	Species:	Danio rerio

Alignment Length:	253	Identity:	80/253 - (31%)
Similarity:	125/253 - (49%)	Gaps:	30/253 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 FPWMVALMDME-GNFVCGGTLIHPQLVLTSAHNVFNRSEDSLLVRAGDWDLNSQTELHPYQ-MRA 275
            :||.|:|...: |...|||:||..:.|||:||.:...||.:|:|..|   ..:|..::.|: .|.
Zfish    47 WPWQVSLHSPKYGGHFCGGSLISSEWVLTAAHCLSGVSETTLVVYLG---RRTQQGINIYETSRN 108

  Fly   276 ISELHRHENFNNLTLYNDIALVVLERPFQVAPHIQPICLPPPETPQMEAELRSASCLATGWG-LR 339
            :::...|.::|:.|..|||||:.|........:|:|:||    ..|........|...|||| ::
Zfish   109 VAKSFVHSSYNSNTNDNDIALLRLSSAVTFTNYIRPVCL----AAQNSVYSAGTSSWITGWGDIQ 169

  Fly   340 YSTSRTMENLLKRIELPAVDHESCQRLL-RHTVLGRRYNLHPSFTCAGGVK-GKDTCMGDGGSPL 402
            ...:.....:|:...:|.|.::.|..|| ..||..       :..|||..: |||||.||.|.|:
Zfish   170 AGVNLPAPGILQETMIPVVANDRCNALLGSGTVTN-------NMICAGLTQGGKDTCQGDSGGPM 227

  Fly   403 ---FCTLPGQKDRYQLVGLVSWGIECAEKDVPAAYTNVAYLRNWIDEQVT--KSGFPL 455
               .||:      :...|:.|||..||:.:.|..||.|:..::||..:::  |.||.|
Zfish   228 VTRLCTV------WVQAGITSWGYGCADPNSPGVYTRVSQYQSWISSKISLNKPGFIL 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8738	NP_610403.1	Tryp_SPc	207..447	CDD:238113	76/241 (32%)
CG8738	NP_610403.1	Tryp_SPc	207..444	CDD:214473	74/238 (31%)
prss60.3	XP_002662541.2	Tryp_SPc	36..269	CDD:238113	76/241 (32%)
prss60.3	XP_002662541.2	Somatomedin_B	294..328	CDD:321959
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587385
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930