Protein Alignment CG8586 and C1R

DIOPT Version :10

• Sequence 1: NP_610402.1
• Gene: CG8586 / 35854
• FlyBaseID: FBgn0033320
• Length: 444
• Species: Drosophila melanogaster
• Sequence 2: NP_001341275.1
• Gene: C1R / 715
• HGNCID: 1246
• Length: 719
• Species: Homo sapiens
• Alignment Length: 366
• Identity: 99/366 - (27%)
• Similarity: 153/366 - (41%)
• Gaps: 72/366 - (19%)

  Fly   103 ESCGQNMECVPRKLCRDNI--INDSGISLINPRISPIQCSKSLYRCCAVDQKVDDSESPYLV--- 162
            :.|||     ||.|...:.  ....|::....||. ..|.:..|:   :..:....||...|
Human   388 KDCGQ-----PRNLPNGDFRYTTTMGVNTYKARIQ-YYCHEPYYK---MQTRAGSRESEQGVYTC 443

  Fly   163 -KQANFKYKNCGYSNPKGL----IPDNDKFPYSEDVSI-------FGEFPWMVGIFT---GRQEF 212
             .|..:|.:..|...|:.|    .|.|   |..:...|       .|.|||.|  ||   ||.
Human   444 TAQGIWKNEQKGEKIPRCLPVCGKPVN---PVEQRQRIIGGQKAKMGNFPWQV--FTNIHGRG-- 501

  Fly   213 LCGGTLIHPRLVVTTSHNLV--------NETVDTLVARAGDWDLNSL-NEPYPHQGSRIKEIIMH 268
              ||.|:..|.::|.:|.|.        |.::|..:......:|..| |.|       |:.:.:|
Human   502 --GGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHP-------IRRVSVH 557

  Fly   269 SEFDPNSLYN---DIALLLLDEPIRLAPHIQPLCLPPPESPELTNQLLSVTCYATGWGTKEAGSD 330
            .::..:..||   |||||.|:..:.|.|::.|:|||..:    |...|.:..|.:|:|..|   :
Human   558 PDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDND----TFYDLGLMGYVSGFGVME---E 615

  Fly   331 KLEHVLKRINLPLVEREECQAKLR-NTRLEARFRLRPSFICAGGDPGK-DTCKGDGGSPLFCQMP 393
            |:.|.|:.:.||:...:.|:..|| ..|::.   ...:..|||....| |.|:||.|. :|....
Human   616 KIAHDLRFVRLPVANPQACENWLRGKNRMDV---FSQNMFCAGHPSLKQDACQGDSGG-VFAVRD 676

  Fly   394 GEMDRYQLVGIVSWGVECAVEDIPAVYVNVPHLRGWIDEKI 434
            ...||:...||||||:.|:..  ...|..|.:...||.:::
Human   677 PNTDRWVATGIVSWGIGCSRG--YGFYTKVLNYVDWIKKEM 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8586	NP_610402.1	CLIP_1	98..147	CDD:465709	11/45 (24%)
		Tryp_SPc	197..433	CDD:238113	76/252 (30%)
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:464251
		CUB	207..316	CDD:395345
		Sushi	323..385	CDD:459664
		CCP	390..461	CDD:153056	18/79 (23%)
		Tryp_SPc	477..711	CDD:214473	75/259 (29%)