DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8586 and KLKB1

DIOPT Version :9

Sequence 1:	NP_001286204.1	Gene:	CG8586 / 35854	FlyBaseID:	FBgn0033320	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	431	Identity:	121/431 - (28%)
Similarity:	188/431 - (43%)	Gaps:	85/431 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 MCLSDERCTSLKRCEDSDDSGRRGIRPRSSRICGTQRVCCEKAQLDSYDRWLVERTTTVPSTIRN 91
            :||       ||..|....|..   .|:.:.|.|...:.|::               |:|....:
Human   266 VCL-------LKTSESGTPSSS---TPQENTISGYSLLTCKR---------------TLPEPCHS 305

  Fly    92 KVSSVLEPPPNESCGQNMECVPRK---LCRDNIINDSGISLINPRISPIQCSKSLYRC-CAVDQK 152
            |:.     |..:..|:.:.....|   :|::..............:.|..|.:.  :| |.:...
Human   306 KIY-----PGVDFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEE--KCKCFLRLS 363

  Fly   153 VDDSESPYLVKQANFKYKNCGYSNPKGLIPDNDKFPYSEDVSI-------FGEFPWMVGI---FT 207
            :|.|.:    :.|.....:.|||.......||..........|       :||:||.|.:   .|
Human   364 MDGSPT----RIAYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLT 424

  Fly   208 GRQEFLCGGTLIHPRLVVTTSHNLVNETVDTLVAR------AGDWDLNSLNEPYPHQGSRIKEII 266
            . |..||||:||..:.|:|.:|     ..|.|..:      :|..:|:.:.:..|.  |:|||||
Human   425 A-QRHLCGGSLIGHQWVLTAAH-----CFDGLPLQDVWRIYSGILNLSDITKDTPF--SQIKEII 481

  Fly   267 MHSEFDPNSLYNDIALLLLDEPIRLAPHIQPLCLPP--PESPELTNQLLSVTCYATGWG-TKEAG 328
            :|..:..:...:||||:.|..|:......:|:|||.  ..|...||      |:.|||| :||.|
Human   482 IHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTN------CWVTGWGFSKEKG 540

  Fly   329 SDKLEHVLKRINLPLVEREECQAKLRNTRLEARFRLRPSFICAG-GDPGKDTCKGDGGSPLFCQM 392
              :::::|:::|:|||..||||.:.::.::..|      .:||| .:.|||.||||.|.||.|:.
Human   541 --EIQNILQKVNIPLVTNEECQKRYQDYKITQR------MVCAGYKEGGKDACKGDSGGPLVCKH 597

  Fly   393 PGEMDRYQLVGIVSWGVECAVEDIPAVYVNVPHLRGWIDEK 433
            .|   .::||||.|||..||..:.|.||..|.....||.||
Human   598 NG---MWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEK 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8586	NP_001286204.1	Tryp_SPc	197..433	CDD:238113	89/248 (36%)
CG8586	NP_001286204.1	Tryp_SPc	197..430	CDD:214473	87/245 (36%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519	9/38 (24%)
		APPLE	303..386	CDD:128519	15/93 (16%)
		Tryp_SPc	401..632	CDD:214473	88/255 (35%)
		Tryp_SPc	402..632	CDD:238113	88/254 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S11393
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860