DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ptc and Ptch1

DIOPT Version :9

Sequence 1:NP_523661.2 Gene:ptc / 35851 FlyBaseID:FBgn0003892 Length:1286 Species:Drosophila melanogaster
Sequence 2:XP_038952062.1 Gene:Ptch1 / 89830 RGDID:621425 Length:1495 Species:Rattus norvegicus


Alignment Length:1360 Identity:492/1360 - (36%)
Similarity:724/1360 - (53%) Gaps:187/1360 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 GKARGSRTAIYLR--SVFQSHLETLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIHSKVHQLWI 106
            |:|.|.|.|...|  .|:........|..:||..:|                             
  Rat   144 GRAGGGRRAGLQRRPRVWSCFWTAFNSGGKKHLSQV----------------------------- 179

  Fly   107 QEGGRLEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDT 171
              |||:..||.||::.|||:.....||:|||..:..|:||..:|||.||:..::|:.|.|::|:.
  Rat   180 --GGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNR 242

  Fly   172 EWGLRDMCNMPSTPSFEGIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQRLLW 236
            :|.|..:| ..|........|::||:.:|.||.|||||||||||::|   :|..........|.|
  Rat   243 QWKLEHLC-YKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKL---QSGTAYLLGKPPLRW 303

  Fly   237 TTLNPASVMQYMKQKMSEEKISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNKNSTQ 301
            |..:|...::.:|      ||::..::.|:.:.:|.:|.|||::|||||.:|:||.||||||||:
  Rat   304 TNFDPLEFLEELK------KINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTK 362

  Fly   302 PPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNY 366
            |.||..:|:|||.|.:.|:|||.|||||||..:|.:|.|..|.|||::.||||.|:||:.::...
  Rat   363 PLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRGYD 427

  Fly   367 KVHHLGWTQEKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALS 431
            .|.|:.|.:::||.:|.||||.:...|.|.:...|    ...:..|::..|||||..||..|.:.
  Rat   428 YVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNS----TQKVLSFTTTTLDDILKSFSDVSVIR 488

  Fly   432 IVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPF 496
            :..|..:.:.||..|:||| |..:.|.:||:|||||:..|.||||||.:|:||.||||:|||:||
  Rat   489 VASGYLLMLAYACLTMLRW-DCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPF 552

  Fly   497 LALGLGVDHIFMLTAAYAES--NRR----EQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPAL 555
            ||||:|||.:|:|..|::|:  |:|    ::|...||:.|.|:..::.|...:||.||.||:|||
  Rat   553 LALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPAL 617

  Fly   556 KVFCLQAAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCC----CF-------PVWKEQP-- 607
            :.|.||||:|:..|.|..||:|||::|:||.||...|.|||||    |.       |....:|  
  Rat   618 RAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTEPHS 682

  Fly   608 --KVAPPVLPLNNNNGRGARH-------------------------PKS------CNNNRVPLPA 639
              :.:||. |.::::.....|                         |:|      ....:..|..
  Rat   683 NTRYSPPP-PYSSHSFAHETHITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTITQDTLSC 746

  Fly   640 QNP--------LLEQRADIPGSSHSL----ASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALI 692
            |:|        ||.|.:|  .|.|.|    ..::|::||.:||.|||:|...|.:.::.||..|.
  Rat   747 QSPESTSSTRDLLSQFSD--SSLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLG 809

  Fly   693 SSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSF 757
            .|||.:||::||||:.|:||:::.|:.|:.||.:.|.||:||.||| ..:||..|.||.|.|.||
  Rat   810 VSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQ-KADYPNIQHLLYDLHKSF 873

  Fly   758 VRVPHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQT 822
            ..|.:|:..:|..||..||..|.:||..||..||.::..||:.... :.|.|.|.:|||||:|||
  Rat   874 SSVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNN-YKNGSDDGVLAYKLLVQT 937

  Fly   823 GHVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEY 887
            |..|.|:|...:...|||::|||||..|||.||:||.:||..||.|||..:.|...::.|...:|
  Rat   938 GSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADY 1002

  Fly   888 ----DLKIPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQ 948
                .|:||.:.|:.|||.||||:||.|||.....|..:|.:...|...||.:||:|.||:||||
  Rat  1003 MPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLFWEQ 1067

  Fly   949 YMTLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVI 1013
            |::||..|.:.::.||....::.::.||:.|.|.::::.:.....::||.|.|:||||||:|.||
  Rat  1068 YISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVI 1132

  Fly  1014 LILSVGMMLCFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIR 1078
            ||.|||:.:.|.|.::|.|:|::|::..|..|:::....|::.|.:::.:.|.||:.|.|:|::|
  Rat  1133 LIASVGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVR 1197

  Fly  1079 HFCWLLLVVLCVGACNSLLVFPILLSMVGPEAELVPLEHPDRISTPSPLP----VRSSKRSGKSY 1139
            :|..:|.::..:|..|.|::.|:|||..||..|:.|....:|:.||||.|    ||.:...|.:.
  Rat  1198 YFFAVLAILTVLGVLNGLVLLPVLLSFFGPCPEVSPANGLNRLPTPSPEPPPSVVRFAVPPGHTN 1262

  Fly  1140 VVQGSRSSRGSCQKS---------HHHHHKDLNDPS---LTTITEEPQSWKSS------------ 1180
            ....|..|..|.|.:         |:...:....|:   :...||.|...:|:            
  Rat  1263 NGSDSSDSEYSSQTTVSGISEELRHYEAQQGTGGPAHQVIVEATENPVFARSTVVHPDSRHQPPL 1327

  Fly  1181 NSSIQ--------MPNDWTYQPREQRPASYAAPPPAYHKAAAQQ--HHQHQGPPT---------- 1225
            ||..|        .|.....|||...|.....|||...:..|.:  ...|.||..          
  Rat  1328 NSRQQPHLDSGSLSPGRQGQQPRRDPPREGLRPPPYRPRRDAFEISTEGHSGPSNRDRSGPHGAR 1392

  Fly  1226 --TPPPPFPTAYPPELQSIVVQPEVTVETTHSDSNTTKVTATANIKVEL---AMPGRAVR 1280
              .|..|..||....:.| ..||            .|.|||:|::.|.:   ..|||..|
  Rat  1393 SHNPRNPTSTAMGSSVPS-YCQP------------ITTVTASASVTVAVHPPPGPGRNPR 1439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ptcNP_523661.2 2A060602 17..1134 CDD:273338 449/1163 (39%)
MMPL 454..598 CDD:304422 77/149 (52%)
Ptch1XP_038952062.1 2A060602 178..1253 CDD:273338 437/1125 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166348809
Domainoid 1 1.000 297 1.000 Domainoid score I1416
eggNOG 1 0.900 - - E1_KOG1935
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H223
Inparanoid 1 1.050 859 1.000 Inparanoid score I407
OMA 1 1.010 - - QHG49297
OrthoDB 1 1.010 - - D1190129at2759
OrthoFinder 1 1.000 - - FOG0003078
OrthoInspector 1 1.000 - - oto96833
orthoMCL 1 0.900 - - OOG6_105508
Panther 1 1.100 - - LDO PTHR46022
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2446
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

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