DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ptc and PTCH2

DIOPT Version :9

Sequence 1:	NP_523661.2	Gene:	ptc / 35851	FlyBaseID:	FBgn0003892	Length:	1286	Species:	Drosophila melanogaster
Sequence 2:	NP_003729.3	Gene:	PTCH2 / 8643	HGNCID:	9586	Length:	1203	Species:	Homo sapiens

Alignment Length:	1252	Identity:	450/1252 - (35%)
Similarity:	688/1252 - (54%)	Gaps:	126/1252 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AQVALDQIDKGKARGSRTAIYLRSVFQSHLETLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIH 98
            |:.|..||..|..   :..::||:.||..|.:||..:|:|.|||||:.:|......:||:.|.|.
Human    18 ARTAAPQILAGSL---KAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIE 79

  Fly    99 SKVHQLWIQEGGRLEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATA 163
            :.:.|||::.|.|:..||.||::.:||:.:.|.|:||||......::|.|:||..||:..:.|:.
Human    80 TNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASK 144

  Fly   164 VKVHLYDTEWGLRDMCNMPSTPSFE-GIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVI 227
            |:|.||...|.|..:|.....|..| |:  ||:::..|.||.|:|||||||||::|.|  .:..:
Human   145 VQVSLYGKSWDLNKICYKSGVPLIENGM--IERMIEKLFPCVILTPLDCFWEGAKLQG--GSAYL 205

  Fly   228 PGLNQRLLWTTLNPASVMQYMKQKMSEEKISF-DFETVEQYMKRAAIGSGYMEKPCLNPLNPNCP 291
            || ...:.||.|:|        :::.||...| ..|...:.:.:|.:|..|:.:|||:|.:.:||
Human   206 PG-RPDIQWTNLDP--------EQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLHPDDLHCP 261

  Fly   292 DTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEK 356
            .:|||.:|.|.|:|...|||||:|::.|.|||.|||::||..|:..|.|.:|:||||...||:.:
Human   262 PSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPR 326

  Fly   357 EMYDQWQDNYKVHHLGWTQEKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDIL 421
            ::|:.::.:|:.|.:||::|:|:.||.||||.|.:..::.|.:.:    :..|:.|||..|||||
Human   327 QLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENA----SQQIHAFSSTTLDDIL 387

  Fly   422 AKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVF 486
            ..||..||..:|.|..:.:.||..|:||| |..:.|.|||:|||||:..:.|:||||.|||||.|
Human   388 HAFSEVSAARVVGGYLLMLAYACVTMLRW-DCAQSQGSVGLAGVLLVALAVASGLGLCALLGITF 451

  Fly   487 NAASTQVVPFLALGLGVDHIFMLTAAYAE----SNRREQTKLILKKVGPSILFSACSTAGSFFAA 547
            |||:|||:||||||:|||.:|:|..|:.|    :..:|:....|::.|.|::.::.:...:|..|
Human   452 NAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMA 516

  Fly   548 AFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPP 612
            |.:|:|||:.|.||||||:.....|.:|||||::|||||||...|.|:.||.......|   ...
Human   517 ALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQ---VIQ 578

  Fly   613 VLPLNNNNG-------------RGARHPKSCNNNRVPL---------PAQNPLLEQRADIPGSSH 655
            :||....:|             :...|.::.:.:.|.:         |..:||..:.....||:.
Human   579 ILPQELGDGTVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTR 643

  Fly   656 SL------------------ASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQ 702
            .|                  |.::||.||...:.|.|::|..|.:.::.|.|.|..|||.:|.:|
Human   644 DLLGQEEETRQKAACKSLPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQ 708

  Fly   703 DGLDIIDLVPKDSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKND 767
            |||.:.|:||:.:.||.||.||.|.|..|.:..||||.|:|...|:.|.|.|..|..:..|:...
Human   709 DGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPP 773

  Fly   768 NGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHVDNPVDKE 832
            ....|..||..:..||..:|..||:::..||:|:.. :.|.|.|..|||||::|||....|:|..
Human   774 ATQAPRTWLHYYRNWLQGIQAAFDQDWASGRITRHS-YRNGSEDGALAYKLLIQTGDAQEPLDFS 837

  Fly   833 LVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYD-----LKIP 892
            .:.|.:||:.:|:|....||..|:.|.::|.....|||...||.|.::.|  ::||     |:||
Human   838 QLTTRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLH--DKYDTTGENLRIP 900

  Fly   893 KSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLA 957
            .:.||.:||.||.|.||..|:.....|...|....:....|:..||||.||:|||||:.||...
Human   901 PAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCF- 964

  Fly   958 MILACVLLAALVLV-SLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMM 1021
            ::..|:||....|| :||||:.|.|.|::|.:.....::||.|..|||||||||.|||:.|||:.
Human   965 LLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIG 1029

  Fly  1022 LCFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLV 1086
            :.|.|.::|||:|:.|:|..|...:::.:..|:..|.:::.:.:.||:.|.|:|::|:|...|.|
Human  1030 VEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTV 1094

  Fly  1087 VLCVGACNSLLVFPILLSMVGPEAELVPL--EHPDRISTPSPLPVRSSKRSGKSYVVQGSRSSRG 1149
            :..:|..:.|::.|:|||::||..|::.:  |.|:.:|.|:|               ||.....|
Human  1095 LTLLGLLHGLVLLPVLLSILGPPPEVIQMYKESPEILSPPAP---------------QGGGLRWG 1144

  Fly  1150 SCQKSHHHHHKDLNDPSLTTITEEPQSWKSSNSSIQMPNDWTYQPREQRPASYAAP----PPAYH 1210
            :             ..||      |||:....:|:.:.   .:.|  ..|.:|..|    ||...
Human  1145 A-------------SSSL------PQSFARVTTSMTVA---IHPP--PLPGAYIHPAPDEPPWSP 1185

  Fly  1211 KAAAQQHHQHQGP-PTT 1226
            .|.:..:...:|| |.|
Human  1186 AATSSGNLSSRGPGPAT 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	430/1153 (37%)
ptc	NP_523661.2	MMPL	454..598	CDD:304422	72/147 (49%)
PTCH2	NP_003729.3	2A060602	12..1142	CDD:273338	432/1166 (37%)
		Sterol-sensing	418..570	CDD:289145	74/151 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1171..1203		9/32 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154920
Domainoid	1	1.000	297	1.000	Domainoid score	I1467
eggNOG	1	0.900	-	-		E1_KOG1935
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	866	1.000	Inparanoid score	I426
Isobase	1	0.950	-	0	Normalized mean entropy	S4544
OMA	1	1.010	-	-		QHG49297
OrthoDB	1	1.010	-	-		D1190129at2759
OrthoFinder	1	1.000	-	-		FOG0003078
OrthoInspector	1	1.000	-	-		otm41186
orthoMCL	1	0.900	-	-		OOG6_105508
Panther	1	1.100	-	-	O	PTHR46022
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2737
SonicParanoid	1	1.000	-	-		X2446
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750