Protein Alignment ptc and DISP2

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: NP_277045.1
• Gene: DISP2 / 85455
• HGNCID: 19712
• Length: 1401
• Species: Homo sapiens
• Alignment Length: 1108
• Identity: 229/1108 - (20%)
• Similarity: 361/1108 - (32%)
• Gaps: 332/1108 - (29%)

  Fly   275 SGYMEKPCLNP---LNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNR 336
            ||.:...||.|   .:|.|.. .|.|.|
Human   377 SGALVPSCLGPGQNKSPRCAQ-VPTKCS------------------------------------- 403

  Fly   337 SGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWT-----QEKAAEVLNAWQRNFSREVEQL 396
                 ::.|:..::..:.:::.......:|:|..|.::     ..|.|.:::.:
Human   404 -----QSSAIYQLLHFLLDRDFLSPQTTDYQVPSLKYSLLFLPTPKGASLMDIY----------- 452

  Fly   397 LRKQSRIATNY---DIYVFSSAALD-----DILAKF-----SHP--SALSIVIGVAVTVLYAFCT 446
               ..|:||.:   |.|. |...:|     ::|..|     .:|  :.::|..|:|:.:...|.|
Human   453 ---LDRLATPWGLADNYT-SVTGMDLGLKQELLRHFLVQDTVYPLLALVAIFFGMALYLRSLFLT 513

  Fly   447 LLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTA 511
            |:         ..:||.|.||:.|         .|..:.|..|   ..||:.|..    :.:|::
Human   514 LM---------VLLGVLGSLLVAF---------FLYQVAFRMA---YFPFVNLAA----LLLLSS 553

  Fly   512 AYAESN-------RREQTKL----ILKKVGPS-------ILFSACSTAGSFFAAAFIPVPALKVF 558
            ..|...       |..:::|    :.::||.:       :|.|..:|:.:|:|:....:||::..
Human   554 VCANHTLIFFDLWRLSKSQLPSGGLAQRVGRTMHHFGYLLLVSGLTTSAAFYASYLSRLPAVRCL 618

  Fly   559 CLQAAIVMCSNLAAALLVFPAMISLDLR-------RRTAGRADIFCCCFPVWKEQPKVAPPVLPL 616
            .|.....:..:||..|:..||...|..|       ||..||          |:..   ||
Human   619 ALFMGTAVLVHLALTLVWLPASAVLHERYLARGCARRARGR----------WEGS---AP----- 665

  Fly   617 NNNNGRGARHPKSCNNNRVPLPAQNPLLEQRADIPGSSHSLASFSLATFAFQHYTP-------FL 674
                            .|:.|.....|...|....|:|..|         ||...|       ::
Human   666 ----------------RRLLLALHRRLRGLRRAAAGTSRLL---------FQRLLPCGVIKFRYI 705

  Fly   675 MRSWVKFLTVMG-FLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTR---LF------- 728
            ...|...|...| ::|.:...|...|....|..:.    :.|:..:..||:.|   ||
Human   706 WICWFAALAAGGAYIAGVSPRLRLPTLPPPGGQVF----RPSHPFERFDAEYRQLFLFEQLPQGE 766

  Fly   729 GFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEE 793
            |.:....:..|.....|...|....:.|.||.|..  :.:|.....|||.......| |..||
Human   767 GGHMPVVLVWGVLPVDTGDPLDPRSNSSLVRDPAF--SASGPEAQRWLLALCHRARN-QSFFD-- 826

  Fly   794 YRDGRLTKECW-----------FPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIIN 847
                 ..:|.|           :..:.|.|.|...|.  .||.|.|...:.
Human   827 -----TLQEGWPTLCFVETLQRWMESPSCARLGPDLC--CGHSDFPWAPQF-------------- 870

  Fly   848 QRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYDLKI----PKSLPLVYAQMPFYLHG 908
               |.:.|...|        ..||   |:..|        ||.:    ..||..:..|.......
Human   871 ---FLHCLKMMA--------LEQG---PDGTQ--------DLGLRFDAHGSLAALVLQFQTNFRN 913

  Fly   909 LTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFW-----EQYMTLRSSLAMILACVLLAAL 968
            ..|.:|.:.....:........|...|....|     |     |.| :|:.||:...|.||..||
Human   914 SPDYNQTQLFYNEVSHWLAAELGMAPPGLRRG-----WFTSRLELY-SLQHSLSTEPAVVLGLAL 972

  Fly   969 VLV-SLLLLSVWAAVLVILSVLASLAQIF---GAMTLLGIKLSAIPAVILILSVGMMLCFNVLIS 1029
            .|. :.|||..|...|.:.||.|....:.   |.:.||..:|:...|:.|..|||:.:.|.|...
Human   973 ALAFATLLLGTWNVPLSLFSVAAVAGTVLLTVGLLVLLEWQLNTAEALFLSASVGLSVDFTVNYC 1037

  Fly  1030 LGF-MTSVGNRQRRVQLSM-QMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGA 1092
            :.: :....:|..||..|: |.|....|.........|.||..:  ..:.|....:|::|.||..
Human  1038 ISYHLCPHPDRLSRVAFSLRQTSCATAVGAAALFAAGVLMLPAT--VLLYRKLGIILMMVKCVSC 1100

  Fly  1093 CNSLLVFPILLSMVGPEAE----LVPLEH-PDRISTPSPLPVRSSKRSGKSYVVQGSRSSR-GSC 1151
            ..:...|..|....|||..    |.|..| |....|..|    ..:::|:..  .||.... |||
Human  1101 GFASFFFQSLCCFFGPEKNCGQILWPCAHLPWDAGTGDP----GGEKAGRPR--PGSVGGMPGSC 1159

  Fly  1152 QKSHHHHHKDL---NDPSLTTITEEPQSWKSSNSSIQMPNDWTYQPREQRPASYAAPPPAYHKAA 1213
              |..:..:.|   ..||..|.|        :.|.:           ..||:           ..
Human  1160 --SEQYELQPLARRRSPSFDTST--------ATSKL-----------SHRPS-----------VL 1192

  Fly  1214 AQQHHQHQGPPTTPPPPFPTAYPPEL----QSIVVQ-PEVTVETTHSDSN-TTKVTATANIKVEL 1272
            ::....|.||..:.|||.| |.|.||    |::..| |.:...:.:..:. :.|..|..:.:.|.
Human  1193 SEDLQLHDGPCCSRPPPAP-ASPRELLLDHQAVFSQCPALQTSSPYKQAGPSPKTRARQDSQGEE 1256

  Fly  1273 AMP 1275
            |.|
Human  1257 AEP 1259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	195/955 (20%)
		MMPL	454..598	CDD:304422	37/168 (22%)
DISP2	NP_277045.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..91
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..138
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..264
		MMPL	<580..646	CDD:304422	16/65 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1169..1192		7/52 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1229..1337		6/31 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1352..1401

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154907
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930