DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ptc and DISP1

DIOPT Version :9

Sequence 1:NP_523661.2 Gene:ptc / 35851 FlyBaseID:FBgn0003892 Length:1286 Species:Drosophila melanogaster
Sequence 2:NP_001356523.1 Gene:DISP1 / 84976 HGNCID:19711 Length:1524 Species:Homo sapiens


Alignment Length:1174 Identity:210/1174 - (17%)
Similarity:395/1174 - (33%) Gaps:343/1174 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 DTEWGL---RDMCNMP-----STPSFEGIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVV 226
            :|.|.|   :.|||:.     |.|.|..:            |...|...|               
Human   311 ETLWNLPAIKSMCNVDNSRIRSHPQFGDL------------CQRTTAASC--------------- 348

  Fly   227 IPGLNQRLLWTTLNPASVMQYMK--QKMSEEKISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPN 289
            .|.      ||..|..:::....  ||:.|..:|...:.:....|....|:          |.|:
Human   349 CPS------WTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGT----------LGPD 397

  Fly   290 CPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMT 354
            |.|.|..:.                          ::|......|.    ..|..|:..::..:.
Human   398 CWDMAARRK--------------------------DQLKCTNVPRK----CTKYNAVYQILHYLV 432

  Fly   355 EKEMYDQWQDNYKVHHLGWTQ-----EKAAEVLNAWQRNF-----SREVEQLLRKQSRIATNYDI 409
            :|:.......:|....|.::.     ||...::|.:..||     |..|..:        |..:.
Human   433 DKDFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDGVTTI--------TGIEF 489

  Fly   410 YVFSSAALDDILAKFSHPSALSIVIGVAVTVLYA---FCTLLRWRDPVRGQSSVGVAGVLLMCFS 471
            .:..|...|.:|....:| |::|||.:.|..:|.   |.|                   |:..|:
Human   490 GIKHSLFQDYLLMDTVYP-AIAIVIVLLVMCVYTKSMFIT-------------------LMTMFA 534

  Fly   472 TAAGLGLSALL-GIVFNAASTQVVPFLAL-------GLGVDHIFML---------TAAYAESNRR 519
            ..:.|.:|..| .:||:   .:..||:.|       |:|.|..|:|         ...:||::  
Human   535 IISSLIVSYFLYRVVFH---FEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETS-- 594

  Fly   520 EQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLD 584
            |...:.|:....|:..::.:||.:|:|.....:.|::.|.:.|...:..|....:...||::.|.
Human   595 ETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLH 659

  Fly   585 LRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRAD 649
            .|.    ..:||.|    :|:      |...:.:|        |||..  |.....:.:|     
Human   660 ERY----LLNIFTC----FKK------PQQQIYDN--------KSCWT--VACQKCHKVL----- 695

  Fly   650 IPGSSHSLASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPK- 713
                   .|....:...|:...|.::..: ::|.:..|||..:...|          |:.:.|| 
Human   696 -------FAISEASRIFFEKVLPCIVIKF-RYLWLFWFLALTVGGAY----------IVCINPKM 742

  Fly   714 -----DSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVP-----HVIKNDN 768
                 :.:|.:.         |.|.:...:.:.||.......|.:|...:.:|     .|...||
Human   743 KLPSLELSEFQV---------FRSSHPFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDN 798

  Fly   769 GG---------------------LPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDA 812
            |.                     ....|:|.|.:.|.|....:..:.:|           .:|..
Human   799 GNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFFYQTDEQD-----------FTSCF 852

  Fly   813 ILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEP 877
            |..:|..::....|.|                     |.|...|.|:              :|..
Human   853 IETFKQWMENQDCDEP---------------------ALYPCCSHWS--------------FPYK 882

  Fly   878 RQYFHQPNEYDLKIPKSLPLVYAQMPFYLHGLT--------DTSQIKTLIGHIRD---LSVKYE- 930
            ::.|      :|.|.:::..:.....::|...|        ||  |:.::...:.   .::.|| 
Human   883 QEIF------ELCIKRAIMELERSTGYHLDSKTPGPRFDINDT--IRAVVLEFQSTYLFTLAYEK 939

  Fly   931 ------------GFGLPNYPSGIP---FIFWEQYMTLRSSLA-MILACVLLAALVLVSLLLLSVW 979
                        ...|.:.|.|:.   |:...::..|:.||: ..|..:.|:..|..|::||:.|
Human   940 MHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTW 1004

  Fly   980 AAVLVILSVLASLAQIF---GAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGF-MTSVGNRQ 1040
            ..::.:.::::....||   |::.|||.:|:.:.:|.:.::||:.:.|.|...:.: :....:|:
Human  1005 NIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDRE 1069

  Fly  1041 RRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSM 1105
            .:|..|:......:....||:.||..|:..|.. .........:::::|:....:...|..:...
Human  1070 GKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTV-LAYTQLGTFMMLIMCISWAFATFFFQCMCRC 1133

  Fly  1106 VGPEAELVPLEHPDRISTPSPLPVRSSKRSGKSYVVQGSRSSRGSCQKSH--HHHHKDLNDPSLT 1168
            :||:.....:          ||| :..:.|..|:.:..|.|.:|. .|:|  :.:|.|...|...
Human  1134 LGPQGTCGQI----------PLP-KKLQCSAFSHALSTSPSDKGQ-SKTHTINAYHLDPRGPKSE 1186

  Fly  1169 TITEEPQSWKSSNSSIQMPNDWTYQPRE------QRPASYAAPP--PAYHKAAAQQHHQHQGPPT 1225
            ...|..:....::.|...|...||:...      ...|.....|  .||:...::......|...
Human  1187 LEHEFYELEPLASHSCTAPEKTTYEETHICSEFFNSQAKNLGMPVHAAYNSELSKSTESDAGSAL 1251

  Fly  1226 TPPP 1229
            ..||
Human  1252 LQPP 1255

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ptcNP_523661.2 2A060602 17..1134 CDD:273338 188/1067 (18%)
MMPL 454..598 CDD:304422 34/160 (21%)
DISP1NP_001356523.1 Patched 435..1131 CDD:355433 151/839 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154927
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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