DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ptc and Disp1

DIOPT Version :9

Sequence 1:NP_523661.2 Gene:ptc / 35851 FlyBaseID:FBgn0003892 Length:1286 Species:Drosophila melanogaster
Sequence 2:XP_036009284.1 Gene:Disp1 / 68897 MGIID:1916147 Length:1557 Species:Mus musculus


Alignment Length:1296 Identity:244/1296 - (18%)
Similarity:426/1296 - (32%) Gaps:404/1296 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 DTEWGL---RDMCNMP-----STPSFEGIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVV 226
            :|.|.|   :.||::.     |.|.|..:            |...|.:.|               
Mouse   346 ETLWNLPAIKSMCDVDNSRIRSHPQFSDL------------CQRTTAVSC--------------- 383

  Fly   227 IPGLNQRLLWTTLNPASVMQYMK--QKMSEEKISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPN 289
            .|.      ||..|..:::....  ||:.|..:|...:.:....|....|:          |.|:
Mouse   384 CPS------WTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGT----------LGPD 432

  Fly   290 CPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMT 354
            |.|.|..:.                          ::|......|.    ..|..|:..::..:.
Mouse   433 CWDKAARRK--------------------------DQLKCTNVPRK----CTKYNAVYQILHYLV 467

  Fly   355 EKEMYDQWQDNYKVHHLGWTQ-----EKAAEVLNAWQRNFSREVEQLLRKQSRI--ATNYDIYVF 412
            :|:.......:|.|..|.::.     ||...::|.:..||..     ......|  .|..:..:.
Mouse   468 DKDFMTPKTADYAVPALKYSMLFSPTEKGESMMNIYLDNFEN-----WNSSDGITTVTGIEFGIK 527

  Fly   413 SSAALDDILAKFSHPSALSIVIGVAVTVLYA---FCTLLRWRDPVRGQSSVGVAGVLLMCFSTAA 474
            .|...|.:|....:| |::|.|.:.:..:|.   |.|                   |:..|:..:
Mouse   528 HSLFQDYLLMDTVYP-AIAIAIVLLIMCVYTKSMFIT-------------------LMTMFAIIS 572

  Fly   475 GLGLSALL-GIVFNAASTQVVPFLAL-------GLGVDHIFMLTAAY---------AESNRREQT 522
            .|.:|..| .:|||   .:..||:.|       |:|.|..|:|...:         ||::  |..
Mouse   573 SLIVSYFLYRVVFN---FEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPRAETS--EAV 632

  Fly   523 KLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLRR 587
            .:.|:....|:..::.:||.:|:|.....:.|::.|.:.|...:..|....:...||:|.|..|.
Mouse   633 SVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERY 697

  Fly   588 RTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRADIPG 652
                ..:||.|   ..|.||:.                :.|||          ..:|.|:.    
Mouse   698 ----LLNIFTC---FRKPQPQA----------------YDKSC----------WAVLCQKC---- 725

  Fly   653 SSHSLASFSLAT-FAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPK--- 713
             ...|.:.|.|: ..|:...|.::..: ::|.::.|||..:...|          |:.:.||   
Mouse   726 -RRVLFAVSEASRIFFEKVLPCIVIKF-RYLWLIWFLALTVGGAY----------IVCVNPKMKL 778

  Fly   714 ---DSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHV----IKNDNGGL 771
               :.:|.:.         |.|.:...:.:.|:.......|.:|...:.:|..    :..::.|.
Mouse   779 PSLELSEFQV---------FRSSHPFERYDAEFKKLFMFERVHHGEELHMPITVIWGVSPEDSGD 834

  Fly   772 P----------------------DFWLLLFSEWLGNLQKIFDEEYRDGRL----TKECWFPNASS 810
            |                      ..|:|.|.:.|.|.......|.:|...    |.:.|..|...
Mouse   835 PLNPKSKGELTLDSTFNIASPASQAWILHFCQKLRNQTFFHQTEQQDFTSCFIETFKQWMENQDC 899

  Fly   811 DAILAYKLIVQTGHVDNPVDK---ELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGK 872
            |....|..   ..|...|..:   ||.:...::..|.                    :.|.....
Mouse   900 DEPALYPC---CSHCSFPYKQEVFELCIKKAIMELDR--------------------STGYHLNN 941

  Fly   873 LYPEPRQYFHQPNEYD---------LKIPKS--LPLVYAQM-PFYLHGLTDTSQIKTLIGHIRDL 925
            ..|.||        :|         |:...:  ..|.|.:| .||       .::.:.|.|  :|
Mouse   942 KTPGPR--------FDINDTIRAVVLEFQSTFLFTLAYEKMQQFY-------KEVDSWISH--EL 989

  Fly   926 SVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLA-MILACVLLAALVLVSLLLLSVWAAVLVILSVL 989
            |...||.....:.|.:      ::..|:.||: ..|..:.|:..|..|::||:.|..::.:.:::
Mouse   990 SSAPEGLSRGWFVSNL------EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIV 1048

  Fly   990 ASLAQIF---GAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGF-MTSVGNRQRRVQLSMQMS 1050
            :....||   |::.|||.:|:.:.:|.:.::||:.:.|.|...:.: :....:|:.:|..|:...
Mouse  1049 SIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRM 1113

  Fly  1051 LGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGPEAELVPL 1115
            ...:....||:.||..|:..|.. .........:::|:||....:...|..|...:||:.....:
Mouse  1114 GSAIAMAALTTFVAGAMMMPSTV-LAYTQLGTFMMLVMCVSWAFATFFFQCLCRCLGPQGTCGQI 1177

  Fly  1116 EHPDRISTPSPLPVRSSKRSG-----KSYVVQG-SRSSRGSCQKSHHHHH----KDLNDPSLT-- 1168
            ..|.::.. ||.....|.|.|     |::.... |..:||  |||...|.    :.|...|.|  
Mouse  1178 PFPTKLQC-SPFSHTLSARPGDRGPSKTHAASAYSVDARG--QKSQLEHEFYELQPLASHSCTSS 1239

  Fly  1169 --TITEEPQS----WKSSNSSIQMP------NDWTYQPREQ------------------------ 1197
              |..|||.:    :.....:::||      ::.|..|..:                        
Mouse  1240 EKTTYEEPHTCSEFFNGQAKNLRMPVPAAYSSELTKSPSSEPGSALLQSCLEQDTVCHFSLNPRC 1304

  Fly  1198 --RPA-----------------------------------SYAAPPPAYHKAAAQQHH--QHQGP 1223
              |.|                                   |..||..|.|:||....|  ||..|
Mouse  1305 NCRDAYTHLQYGLPEIHCQQMGDSLCHKCASTAGGFVQIQSSVAPLKASHQAAEGLLHPAQHMLP 1369

  Fly  1224 P---TTPPPPFPTAYPPELQSIVVQPEVTVETTHSDSNTTKVTATANIKVELAMPGRAVRS 1281
            |   .:.|..|   :...:|....|..:...:|||.......||      ||:.|....||
Mouse  1370 PGMQNSRPRNF---FLHSVQHFQAQENLGRTSTHSTDERLPRTA------ELSPPPSDSRS 1421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ptcNP_523661.2 2A060602 17..1134 CDD:273338 195/1057 (18%)
MMPL 454..598 CDD:304422 36/160 (23%)
Disp1XP_036009284.1 Patched 470..1150 CDD:355433 153/814 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845397
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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