Protein Alignment ptc and Ptchd3

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: XP_003751038.1
• Gene: Ptchd3 / 688333
• RGDID: 1590039
• Length: 905
• Species: Rattus norvegicus
• Alignment Length: 1080
• Identity: 203/1080 - (18%)
• Similarity: 398/1080 - (36%)
• Gaps: 302/1080 - (27%)

  Fly    66 LGSSVQKHAGKVLFVAILVLSTFCVGL----KSAQIHSKVHQLWIQEGGRLEAELAYTQKTIGED 126
            ||:.|..:....|...:|:.::...||    |..:   .:.:.:...|...:||..:.|.....:
  Rat    85 LGALVGANPWLFLLGPVLLTASLGTGLIFLPKEKE---NLEEQYTPIGSPAKAERRFVQSHFSTN 146

  Fly   127 ESATHQLLIQTTHDPN-ASVLHPQALLAHLEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFEGI 190
            :|.... ..:|:.:.| ||:|    :::|.:.|::..|                       |..:
  Rat   147 DSYRFS-ASRTSSETNFASIL----VVSHRDSLLEPEA-----------------------FAEV 183

  Fly   191 YYIEQILRHLIPCSIITPLDCFWEGSQLLGPE-----SAVVIPGLNQRLLWTTLNPASVMQYMKQ 250
            ..:::.::.|   .::..     .|:|:|.||     |...:|.          ||.........
  Rat   184 SRLDRAVQAL---KVVQE-----NGTQILYPEVCAKYSVGCVPP----------NPLLFSWQQNS 230

  Fly   251 KMSEEKISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNKNSTQPPDVGAILSGGCYG 315
            .::..:::|...:|..::...|                                  ....|...|
  Rat   231 SLNLSELTFPIHSVADHLIHLA----------------------------------GFFGGNVLG 261

  Fly   316 YAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTE----KEMYDQWQDNYKVHHLGWTQE 376
            ||.          .|..:|     |.:::|::.:..|.||    :|....|..::..|......:
  Rat   262 YAT----------TGNRQR-----LVESRAMRLLYYLKTEDPEDRERSQAWLTHFLDHFNDMKSD 311

  Fly   377 KAAEVLN-AWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVIGVAVTV 440
            .|.|.:. .:..:.||::|                  ..|....::..| |.:.:.|::...|:
  Rat   312 LALEDIEVVYFTSLSRQLE------------------FEATSKTVIPLF-HLAYILIILFAVVS- 356

  Fly   441 LYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVV-----PFLALG 500
                |:.|   |.:|.:..|.|.||..:..|..:|.||...:|:.|      |:     |||.||
  Rat   357 ----CSRL---DCIRNKMWVAVFGVFSVAMSVVSGFGLMLHIGVPF------VIIVANSPFLILG 408

  Fly   501 LGVDHIFMLTAAYAESNRREQTKLIL----KKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQ 561
            :|||.:|::.:|:.:::..|.....|    .||..||..:..:...:|:........:::.||:.
  Rat   409 VGVDDMFIMISAWQKTSLTESVSERLSNSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIY 473

  Fly   562 AAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARH 626
            ....:......::..|.|:::||.:|...         :..|.|:|            :.:.:..
  Rat   474 TGTTLLFCYFYSITCFGAIMALDGKREVV---------WSRWLEKP------------DQKYSSF 517

  Fly   627 PKSCNNNRVPLPAQNPLLEQRADIPGSSHSLASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAAL 691
            .|.|   .||.          ...| ..|...:..:..|...::.|||..|..||:.|:.::..:
  Rat   518 KKFC---CVPF----------GSFP-DEHGDDNHPMNLFFRDYFGPFLTTSKAKFIVVLIYIFYI 568

  Fly   692 ISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFYS---MYAVTQG-NFEYPTQQQLLRD 752
            |||:|...::|:|||:.:|...||....:.:.:...|..|.   |..||:. |:.....:|.|..
  Rat   569 ISSIYGCFQVQEGLDLRNLASDDSYITPYFNVEEDYFSDYGPRVMVIVTETVNYWDKDVRQKLDK 633

  Fly   753 YHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYK 817
            ....|.:..:|.||    |.:|||..:.:::.|
  Rat   634 CMTQFEQNEYVDKN----LTEFWLEAYMQYMNN-------------------------------- 662

  Fly   818 LIVQTGHVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFH 882
                ||  :||.||     |..:|     |...|.|:...:.
  Rat   663 ----TG--NNPNDK-----NTFMN-----NIAGFLNFFPVFT----------------------- 688

  Fly   883 QPNEYDLKIPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWE 947
                ||:.:..|..:..::.......::.:|..|.::..:|.::   |...:|.......||:::
  Rat   689 ----YDINVSSSNEITSSRGFIQTIDVSSSSNKKRMLLKLRGIA---ENCEVPLMVYNQAFIYFD 746

  Fly   948 QYM-----TLRSSLAMILACVLLA--ALVLVSLLLL-----SVWAAVLVILSVLASLAQIFGAMT 1000
            ||.     |:|:        |::|  |:.:|||||:     |:|    |..::.:.:..:.|.|.
  Rat   747 QYAAIIENTVRN--------VMIASTAMFIVSLLLIPHPVCSLW----VTFAIASVIVGVTGFMA 799

  Fly  1001 LLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGNRQRRVQLSMQMSLG-PLVHGMLTSGVA 1064
            ...:.|.:|..:.|::.:|....|:..||..|::|......:..:.....|| |::...:::.:.
  Rat   800 FWNVNLDSISMINLVICIGFSFDFSAHISYAFVSSNEPSVNKKSIEALYLLGYPVLQSAISTIIG 864

  Fly  1065 VFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLS 1104
            |.:|:.:. .::.|.|..::.:|:..||.:.|:..|:.|:
  Rat   865 VCVLAAAK-AYIFRTFFKIMFLVMFFGAAHGLIFIPVFLT 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	203/1080 (19%)
		MMPL	454..598	CDD:304422	36/152 (24%)
Ptchd3	XP_003751038.1	Patched	125..905	CDD:280598	195/1037 (19%)
		MMPL	362..500	CDD:304422	35/143 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348797
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1935
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740