Protein Alignment ptc and DISP3

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: NP_065831.1
• Gene: DISP3 / 57540
• HGNCID: 29251
• Length: 1392
• Species: Homo sapiens
• Alignment Length: 1112
• Identity: 200/1112 - (17%)
• Similarity: 357/1112 - (32%)
• Gaps: 382/1112 - (34%)

  Fly   301 QPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHL-------RKAQALQSVVQLMTEKEM 358
            :|.:|...|..|.|.|.:.    |..|:.......|.|.:       ..|....|:...||..|.
Human   317 KPHEVLKDLPLGSYSYCSP----PSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEF 377

  Fly   359 YDQW-------QDNYKVHHLGWTQEKAAEVL------------NAWQ------RNFSREVEQLLR 398
            |  |       .||.|...|      .:|:|            :.|:      ::|......:|.
Human   378 Y--WYVDEGLSADNLKSSLL------RSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLA 434

  Fly   399 KQ--SRIATNY---DIYVFSSAAL--DDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRG 456
            ||  |::...|   |::.:.....  :|:|..|...|.::     |:..:...|::.
Human   435 KQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIA-----ALVYILTSCSVF-------- 486

  Fly   457 QSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYAESNRREQ 521
            .|..|:|.:.|.|.  .|......:.||.:......|..|:.:|:|||.:|:....|.::...|.
Human   487 LSFFGIASIGLSCL--VALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLED 549

  Fly   522 TKL----ILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMIS 582
            .:|    .::..|.:..|::.:||.::.|..|..:||:..|.|..::::.....|.|:..||.:.
Human   550 PQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALG 614

  Fly   583 LDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNN---RVPL------- 637
            |                   |...      :.||.::      ...||:.|   :..|
Human   615 L-------------------WSLY------LAPLESS------CQTSCHQNCSRKTSLHFPGDVF 648

  Fly   638 ---------PAQNPLLEQRADIP-------GSSHSLASFSLATFAFQHYTPF------------- 673
                     |||.|:.....|||       ..|..|...||.:.:.:...|.
Human   649 AAPEQVGGSPAQGPIPYLDDDIPLLEVEEEPVSLELGDVSLVSVSPEGLQPASNTGSRGHLIVQL 713

  Fly   674 --LMRSWV-------KFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFG 729
              |:..||       :::.|..|::.||.||..::||:.......|...|:|....||.:..|..
Human   714 QELLHHWVLWSAVKSRWVIVGLFVSILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSA 778

  Fly   730 -----------FYSMYAVTQGNFEYPTQQQ--------------LLRDY-------------HDS 756
                       |.......|.|.....:::              .|:|:             |.:
Human   779 EGISCITCSGLFQEKPHSLQNNIRTSLEKKRRGSGVPWASRPEATLQDFPGTVYISKVKSQGHPA 843

  Fly   757 FVRVP---------HVIKNDNGGLPDF--------------------------------WLLL-- 778
            ..|:.         ..:...:|.:|.|                                |:|.
Human   844 VYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGNFTKKLTACMSTVGLLQAASPSRKWMLTTL 908

  Fly   779 -----------FSEWLGNLQK------IFDEEYR---DGRL----------------TKECWF-- 805
                       ||.::...::      .|.:.::   .||:                ||..:|
Human   909 ACDAKRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRVCMAPPGCLLSSSPDGPTKGFFFVP 973

  Fly   806 ----PNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLV----NSDGIINQRAFYNYL------- 855
                |.|...|...:...|.|| ...|..:.||.|..:|    ...|:...|...|::
Human   974 SEKVPKARLSATFGFNPCVNTG-CGKPAVRPLVDTGAMVFVVFGIIGVNRTRQVDNHVIGDPGSV 1037

  Fly   856 --------------------SAWATNDVFAYGASQ----GKLYPEPRQYFHQPNEYDLKIPKSLP 896
                                :..|.:::...|.:|    |.......|..| |...:|..|..||
Human  1038 VYDSSFDLFKEIGHLCHLCKAIAANSELVKPGGAQCLPSGYSISSFLQMLH-PECKELPEPNLLP 1101

  Fly   897 LVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGF---GLPNYPSGIPFIFWEQYMT------- 951
               .|:.   ||.....:     |.::.:|:.:|..   |..::.:...::.||.::.
Human  1102 ---GQLS---HGAVGVRE-----GRVQWISMAFESTTYKGKSSFQTYSDYLRWESFLQQQLQALP 1155

  Fly   952 ------------------------LRSSLA----MILACVLLAALVLVSLLLLSVWAAVLVILSV 988
                                    ::|:|.    .:|.||...|:....:|||     :.|:||:
Human  1156 EGSVLRRGFQTCEHWKQIFMEIVGVQSALCGLVLSLLICVAAVAVFTTHILLL-----LPVLLSI 1215

  Fly   989 LASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGN------------RQR 1041
            |..:..:...|...|.::.|:.|:.|.:.||..:.:.|.:..|::.:..|            ||.
Human  1216 LGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQW 1280

  Fly  1042 RVQLSMQMSLGPLVHGMLTSGVA---VFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILL 1103
            |...:::.....:|...||:.:|   :|....:||    ..|..::.:...|....:|.|...||
Human  1281 RTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPF----AKFGKIVALNTGVSILYTLTVSTALL 1341

  Fly  1104 SMVGPEA 1110
            .::.|.:
Human  1342 GIMAPSS 1348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	200/1112 (18%)
		MMPL	454..598	CDD:304422	33/147 (22%)
DISP3	NP_065831.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..40
		DUF883	102..>170	CDD:295076
		FXMRP1_C_core	148..255	CDD:289039
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..248
		MMPL	485..615	CDD:304422	32/139 (23%)
		MMPL	<1238..1343	CDD:304422	23/108 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154910
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930