| Sequence 1: | NP_523661.2 | Gene: | ptc / 35851 | FlyBaseID: | FBgn0003892 | Length: | 1286 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000255.2 | Gene: | PTCH1 / 5727 | HGNCID: | 9585 | Length: | 1447 | Species: | Homo sapiens |
| Alignment Length: | 1369 | Identity: | 506/1369 - (36%) |
|---|---|---|---|
| Similarity: | 759/1369 - (55%) | Gaps: | 149/1369 - (10%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 24 DLYIRTSWVDAQVALDQIDKGKARGSRTAIYLRSVFQSHLETLGSSVQKHAGKVLFVAILVLSTF 88
Fly 89 CVGLKSAQIHSKVHQLWIQEGGRLEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALLA 153
Fly 154 HLEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFEGIYYIEQILRHLIPCSIITPLDCFWEGSQL 218
Fly 219 LGPESAVVIPGLNQRLLWTTLNPASVMQYMKQKMSEEKISFDFETVEQYMKRAAIGSGYMEKPCL 283
Fly 284 NPLNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQS 348
Fly 349 VVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFS 413
Fly 414 SAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGL 478
Fly 479 SALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYAES--NRR----EQTKLILKKVGPSILFSA 537
Fly 538 CSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCC-CFP 601
Fly 602 VWKEQPKVAPPVLPLNNNNGRGARHPKSCNNN--------------------------------- 633
Fly 634 -----------RVPLPAQNP--------LLEQRADIPGSSHSL----ASFSLATFAFQHYTPFLM 675
Fly 676 RSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFYSMYAVTQGN 740
Fly 741 FEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWF 805
Fly 806 PNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQ 870
Fly 871 GKLYPEPRQYFHQPNEY----DLKIPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEG 931
Fly 932 FGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQIF 996
Fly 997 GAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTS 1061
Fly 1062 GVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGPEAELVPLEHPDRISTPSP 1126
Fly 1127 LP----VRSSKRSGKSYVVQGSRSSRGSCQKS---------HHHHHKDLNDPSLTTITEEPQSWK 1178
Fly 1179 SSNSSIQMPNDWTY---QPREQRPASYAAPPPAYHKAAAQQHHQHQGPPTTPPPP--FPTAYPPE 1238
Fly 1239 LQSIVVQPEVTVETTHSDSN--------------------------------TTKVTATANIKVE 1271
Fly 1272 LAMP 1275 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| ptc | NP_523661.2 | 2A060602 | 17..1134 | CDD:273338 | 471/1180 (40%) |
| MMPL | 454..598 | CDD:304422 | 77/149 (52%) | ||
| PTCH1 | NP_000255.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..43 | ||
| 2A060602 | 43..1206 | CDD:273338 | 469/1176 (40%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1189..1234 | 13/44 (30%) | |||
| PHA03377 | <1253..1369 | CDD:177614 | 21/128 (16%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1270..1360 | 18/102 (18%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165154929 | |
| Domainoid | 1 | 1.000 | 297 | 1.000 | Domainoid score | I1467 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG1935 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H223 | |
| Inparanoid | 1 | 1.050 | 866 | 1.000 | Inparanoid score | I426 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG49297 | |
| OrthoDB | 1 | 1.010 | - | - | D1190129at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0003078 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41186 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_105508 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR46022 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2737 |
| SonicParanoid | 1 | 1.000 | - | - | X2446 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 16 | 15.800 | |||||