DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ptc and ptchd4

DIOPT Version :9

Sequence 1:	NP_523661.2	Gene:	ptc / 35851	FlyBaseID:	FBgn0003892	Length:	1286	Species:	Drosophila melanogaster
Sequence 2:	NP_001025356.1	Gene:	ptchd4 / 564097	ZFINID:	ZDB-GENE-041001-178	Length:	897	Species:	Danio rerio

Alignment Length:	1022	Identity:	206/1022 - (20%)
Similarity:	350/1022 - (34%)	Gaps:	344/1022 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 PGLNQRLLWTTLNPASVMQYMKQKMSEEKISFDFETVEQYMKRAAIGSGY----------MEKPC 282
            ||...||:....:..::::..:|.:...|...|       |:....|..|          .:|.|
Zfish    91 PGRYGRLILLARSGGNILELAEQVLQVHKKVLD-------MRVNYKGFNYTFAHLCVLRHRDKRC 148

  Fly   283 L-----------------NPLNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVG 330
            |                 |......|.:.||          ..|..|...:....:        |
Zfish   149 LLDDIITIFEDIRLAVLSNSTFSKVPVSYPN----------TTLKDGRVSFIGHQL--------G 195

  Fly   331 GA---KRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLG-WTQEKAAEVLNAWQRNFSR 391
            |.   ..||...::.|:|:|.                .|.:.:|| ..|:..||   .|:..|.:
Zfish   196 GVALPANNRDQQVKFARAIQI----------------TYYLRNLGPVVQDIIAE---KWETEFCK 241

  Fly   392 EVEQLLRKQSRIAT-NYDIYVFSSAALDDILAKFS-----HPS---ALSIVIGVAVTVLYAFCTL 447
            .|.||       || :.::::.|       |..||     |.:   |.|.|:...|.||.|....
Zfish   242 LVHQL-------ATDSQELHIQS-------LTSFSLWRDFHKTGVLAKSEVLVSLVLVLLAATIS 292

  Fly   448 LRWRDPVRGQSSVGVAGVLLMCFS--TAAGLGL-------SALLGIVFNAASTQVVPFLALGLGV 503
            ...||.:||:..:|:.|||.:|.:  ||||:..       |.||||          ||.|:|.|.
Zfish   293 SSMRDCLRGKPFLGLLGVLTICIANVTAAGIFFISDGKFNSTLLGI----------PFFAMGHGT 347

  Fly   504 DHIFMLTAAYAESNRREQTKLILK-KVGPSIL-FSACSTAGSFF--------AAAFIPVPALKVF 558
            ..:|.|.|.:    ||.:..|..| :|..:.. ...|.|..|..        |:.|..:.::|||
Zfish   348 KGVFELLAGW----RRTRESLPFKERVADAFADVMVCYTMTSSLYIITFGMGASPFTNIESVKVF 408

  Fly   559 CLQAAIVMCSN------LAAALLVFPAMISLDLRRRTAGRAD------IFCCCFP---VWKEQPK 608
            |....:.:..|      ...:.|||            ||:.:      :|||..|   ....||.
Zfish   409 CQSMCVAVLVNYFYVFSFYGSCLVF------------AGQLEQNRYHSVFCCKIPSVEYLDRQPT 461

  Fly   609 VAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRADIPGSSHSLASFSLATFAFQHYTPF 673
            ....::    ::|    |..|.:::.||.  ||..::.                  |..:|||.:
Zfish   462 WFKTMM----SDG----HDLSTHHDSVPY--QNHFIQH------------------FLREHYTEW 498

  Fly   674 LMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDS-------NEHKFLDAQTRLFGFY 731
            :..::||...|:.:|.....|.....::.||.:||:|:..:|       .:.|:....:.:.|||
Zfish   499 ITNTYVKPFVVILYLIYASFSFMGCLQISDGSNIINLLASNSPSVSFALTQQKYFSNYSPVIGFY 563

  Fly   732 SMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGN----LQKIFDE 792
            ....:...|   .|.|:.|:.....|.::                    .|:.|    |:.:
Zfish   564 IYEPIEYWN---STVQEHLKTLGQGFNKI--------------------SWIDNYFHFLRVV--- 602

  Fly   793 EYRDGRLTKECWFPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSA 857
                          |.|:.....:..|::|..:.:|..:..|        |.||
Zfish   603 --------------NISASTKSDFISILKTSFLRSPEYQHFV--------DDII----------- 634

  Fly   858 WATNDVFAYGASQGKLYPEPRQYFHQPNEYDLKIPKSLPLVYAQMPFYLHGLT---DTSQIKTLI 919
            ::.|     ||                 |||:...|          .||...|   ...::..|:
Zfish   635 FSKN-----GA-----------------EYDIIASK----------MYLVARTTEKTREEVVELL 667

  Fly   920 GHIRDL----SVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSLLLLSVWA 980
            ..:|.|    |:|:..|.    |:   |:|.::|.:...|..:.....:|..|:|...|:::...
Zfish   668 ERLRPLSLINSIKFIVFN----PT---FVFMDRYSSSIISPILTSGFSVLTILILTFFLVINPLG 725

  Fly   981 AVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILI--LSVGMMLCFNVLISLGFMTSVGNRQRRV 1043
            ...:||:|.:....:.|.|||..:.:.:|..:.||  |:..|..|...|.:....|. ..|.:.:
Zfish   726 NFWLILTVTSVELGVLGLMTLWNVDMDSISILCLIYTLNFAMDHCAPHLYTFVLATE-HTRTQCI 789

  Fly  1044 QLSMQMSLGPLVHG-MLTSGVAVFMLSTSPFEFVIRHFCWLLL-VVLCVGACNSL---LVFPILL 1103
            ::|::      .|| .:....:.|::...|..||..:..:.|. ..|....|..|   ::.|:.|
Zfish   790 KISLE------EHGAAILQNTSCFVIGIMPLLFVPSNLTYTLFKCSLLTAGCTVLHCFVILPVFL 848

  Fly  1104 SMVGP---------------------------EAELVPL-EHPDRIS 1122
            :...|                           |.|.:.: |:||.::
Zfish   849 TFFPPSKKRHKKKKRAKRKEREREREREREREEIECIEVRENPDHVT 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	206/1022 (20%)
ptc	NP_523661.2	MMPL	454..598	CDD:304422	45/174 (26%)
ptchd4	NP_001025356.1	Patched	97..853	CDD:280598	197/972 (20%)
		MMPL	298..449	CDD:304422	46/176 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	856..881		0/24 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840