Protein Alignment ptc and ptchd1

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: XP_690754.1
• Gene: ptchd1 / 562268
• ZFINID: ZDB-GENE-061220-1
• Length: 887
• Species: Danio rerio
• Alignment Length: 1135
• Identity: 229/1135 - (20%)
• Similarity: 391/1135 - (34%)
• Gaps: 366/1135 - (32%)

  Fly    55 LRSVFQSHLET----LGSSVQKHAGKVLFVAILVLSTFCVGLKSA--QIHSKV-------HQLWI 106
            ||.|....|.|    ||..|..|  .|.|.:..||.:..:|...:  :|...|       |.|..
Zfish     2 LRQVLHEGLRTSFHKLGHFVANH--PVFFASAPVLISILLGASFSRYRIEENVEYLLAPKHSLAK 64

  Fly   107 QEGGRLEA--ELAYTQKTIGED--ESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVH 167
            .||..:::  .:..::.|:..|  ....:..:|.|:.  ..|||.|..:.:.|::....|.::|.
Zfish    65 IEGNLVDSLFPVNRSKHTLYSDLQTPGRYGRVIVTSR--RGSVLDPHHVNSVLKLHNTITQIQVP 127

  Fly   168 LYDTEWGLRDMCNMPSTPSFEGIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQ 232
            :....:....:|.:..:.|    ..::.|||
Zfish   128 MLGFNYTFAHLCLLDESKS----CIVDDILR---------------------------------- 154

  Fly   233 RLLWTTLNPASVMQYMKQKMSEEKISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNK 297
                       |::.|                     |:|..|.:...|...|:..
Zfish   155 -----------VLEEM---------------------RSARASNHSVPPLRYPITK--------- 178

  Fly   298 NSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGG--AKRNRSGHLRKAQALQSVVQLMTEKEMYD 360
                       |..|...|....:        ||  |...|.| :|.|:|||....|
Zfish   179 -----------LKDGREAYIGHQL--------GGVLASGGRDG-VRSARALQLTYYL-------- 215

  Fly   361 QWQDNYKVHHLGWTQEKAAEVLN-----AWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDI 420
                            :|...||     :|:..|.||:|...:....::    ::.|:|::|...
Zfish   216 ----------------QAVSPLNEVVAASWELLFCRELENFGKAHPELS----LHPFTSSSLQRD 260

  Fly   421 LAKFSHPSALSIVIGVAVTVLYAF--CTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLG 483
            ..:.|..|...::..:||.:..|.  |::   ||.||.:..:|:..::.:..:|....|:..|.|
Zfish   261 FQRTSRVSERPLLFSLAVCLSLAMLCCSM---RDCVRTKPWLGLLALVTVSLATLTSAGILNLTG 322

  Fly   484 IVFNAASTQV-VPFLALGLGVDHIFMLTAAYAESNRREQTKLILKKVGPSILFSAC------STA 541
            ..:|  ||.: :||:.||.|:...|.:.:::..:...:..|   ::|  :.:||.|      |||
Zfish   323 GKYN--STYLGIPFVMLGHGLFGTFEMLSSWRRTREDQHVK---ERV--AAVFSDCMLPFTASTA 380

  Fly   542 -----GSFFAAAFIPVPALKVFCLQAAIVMCSNLAAAL------LVFPAMISLDLRRRTAGRADI 595
                 ....|:.|..:.|:::||..|.|.:..|....|      |||            ||.
Zfish   381 LHVVTFGIGASPFTNIEAVRLFCQNACISVLFNYLYILTFYGSNLVF------------AGY--- 430

  Fly   596 FCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQR------------- 647
                                |.||    .||...|  .|||.|   .||:|:
Zfish   431 --------------------LENN----YRHSLFC--RRVPKP---ELLQQKPAWYRFLMYTHYN 466

  Fly   648 --ADIPGSSHSLASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDL 710
              |...|...:..|..|..|..::|..::..::||...|:.:|..:..:|....::.:|.|:.::
Zfish   467 EEATEAGPLCAYESHLLVAFMKRYYCDWITNTYVKPFVVLFYLVYVSFALMGYLQVSEGSDLSNV 531

  Fly   711 VPKDSNEHKFLDAQTRLF-------GFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDN 768
            |..:::...:..||.|.|       |||...::...|..  .|:.|| :|...|.|:.
Zfish   532 VATETSTIAYTRAQQRYFSSYSPVIGFYIYESIEYWNTS--VQEDLL-EYIKGFERIS------- 586

  Fly   769 GGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHVDNPVDKEL 833
                  |   |..:|..|..:        .:|......|
Zfish   587 ------W---FESYLNYLHGL--------NITTSLSRSN-------------------------- 608

  Fly   834 VLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYDLKIPKSLPLV 898
             .|.||  ..|.:.|..:.::     |:|:.....|.|              |:|         |
Zfish   609 -FTERL--RSGFLRQPRYVHF-----TDDIIFAKRSDG--------------EFD---------V 642

  Fly   899 YAQMPFYLHGLTDT--SQIKTLIGHIRDLS----VKYEGFGLPNYPSGIPFIFWEQYMTLRSSLA 957
            .|...|.:...|:.  .::..|:..:|.||    ||:..|.    ||   |::.::|   .||:.
Zfish   643 VASRMFLIAKTTENKREEMSILLDTLRKLSLTSRVKFIIFN----PS---FVYMDRY---ASSVG 697

  Fly   958 MILACVLLAALVLVSLL-------LLSVWAAVLVILSVLASLA-QIFGAMTLLGIKLSAIPAVIL 1014
            ..|....:|||.|:...       |::.|..|.|     ||:. .:.|.|||..::|..:..:.|
Zfish   698 APLKNSCIAALFLLFFSTFLAADPLVNAWLTVTV-----ASVEFGLVGFMTLWRVELDCVSVLCL 757

  Fly  1015 ILSVGMMLCFNV-LISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIR 1078
            |..|...:..:. |:|...:.....|.|.|:|:::....|.:...|..|.|:..|:..|......
Zfish   758 IYGVNYAVDSSAPLVSAFALGRESTRTRWVKLALEQHGVPALQSYLCYGAALLPLAAVPSNLTRT 822

  Fly  1079 HFCWLLLVVLCVGACNSLLVFPILLSMVGP 1108
            .|..|.|..: :.|.:.|.:.|:||:.:.|
Zfish   823 LFRCLFLTAI-ITAFHCLAILPVLLTFLPP 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	229/1135 (20%)
		MMPL	454..598	CDD:304422	38/161 (24%)
ptchd1	XP_690754.1	Patched	92..851	CDD:280598	206/1041 (20%)
		MMPL	292..442	CDD:304422	44/197 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589944
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930