DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ptc and disp2

DIOPT Version :9

Sequence 1:	NP_523661.2	Gene:	ptc / 35851	FlyBaseID:	FBgn0003892	Length:	1286	Species:	Drosophila melanogaster
Sequence 2:	XP_005158826.1	Gene:	disp2 / 405793	ZFINID:	ZDB-GENE-030915-1	Length:	1477	Species:	Danio rerio

Alignment Length:	1021	Identity:	190/1021 - (18%)
Similarity:	308/1021 - (30%)	Gaps:	382/1021 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 FQSHLETLGSSVQKHAGKVLFVAIL----------------VLS---TF--CV--GLKSAQIHSK 100
            |:..|.|||... .....:||:.||                ||:   |:  ||  |:|.....|:
Zfish   698 FRQKLRTLGRGF-SDTSNLLFLKILPCGVVKFRYIWICWFAVLAAGGTYISCVDPGMKLPTSDSR 761

  Fly   101 VHQLWIQEG--GRLEAE----LAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQA--------- 150
            ..||:....  .|.:||    ..:.:...||||.....|:.......|.....|::
Zfish   762 TTQLFRSSHPFERYDAEYRHQFMFERMKDGEDEPMMLTLIWGIVPSDNGDHFDPKSNGSLSVDPG 826

  Fly   151 -LLAHLEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFEGIYYIEQ--------ILRHLIPCSII 206
             .::.|:..:             | |||:|......:|......||        .:.|||.
Zfish   827 FNMSSLQAQI-------------W-LRDLCGKIQNQTFYSPLSAEQDTAEDNVCFVEHLIH---- 873

  Fly   207 TPLDCFWEGSQLLGPESAVVIPGLNQRLLWTTLNPASVMQYMKQKMSEEKISFDFETVEQYMKRA 271
                                         |.::          ::.||.:.:|.|
Zfish   874 -----------------------------WVSI----------RRCSESEDAFSF---------- 889

  Fly   272 AIGSGYMEKPCLNPLNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEEL-IVGGAKRN 335
                      |.|    |.|...|.:...|           |........|....| ..||.:.:
Zfish   890 ----------CCN----NIPFPYPPRVFEQ-----------CLSMMVAEQHAEGRLPSAGGLRFD 929

  Fly   336 RSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNAWQRNFSREVEQLLRK- 399
            ..|.:.....:...|||.:..  |::....|:            |:|:.:.|..|:....|.|.
Zfish   930 SEGRIAALVVIFKTVQLYSFN--YNRMSQFYQ------------EILSWFNREISKAPAGLQRGW 980

  Fly   400 -QSRIATNYDI-YVFSSAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGV 462
             .|::.. ||: ...||..|:              |.|.:|.:.:|...|..|..|:....|:.|
Zfish   981 FVSQLGL-YDLQQCLSSETLE--------------VAGFSVALTFALLLLTTWNIPLSVYVSIAV 1030

  Fly   463 AGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYA---ESNRREQTKL 524
            ||      |..|.:||..||....|......:. .|.||.||.:.....:|:   .|:|..:...
Zfish  1031 AG------SVFATVGLLVLLEWQLNGVEALFIS-AAAGLSVDFVANYCISYSLAPHSDRLGRVAH 1088

  Fly   525 ILKKVGPSILFSACSTAGSFFAAAFIPVPA-------LKVFCLQAAIVMCSNLAAALLVFPAMIS 582
            .:|::|..:    .:.||::|....|.:||       |.:|.|   :|.|.....|...|.::
Zfish  1089 SIKRMGCPV----ATGAGAYFCVGIIMLPATALLFRKLGIFLL---LVKCVACGFATFFFQSL-- 1144

  Fly   583 LDLRRRTAGRADIFCCCFPVWKEQPKVAPPVL----------------PLNNNN--------GRG 623
                          ||.|.......::..|.:                |..||.        |:|
Zfish  1145 --------------CCFFGPQNNCGRITLPCVTQQSTENILSSCSATEPGTNNPAANGAFGCGKG 1195

  Fly   624 ARHPKSCN--------------NNRVPL----PAQN---PLLEQRADIPGSSHSLASFSLATFAF 667
            :|..:|.|              ..|.|:    |.||   ||..|.:|                :|
Zfish  1196 SRVRRSFNKENEGFLCPNQQHHRKRQPVGGREPEQNELQPLACQLSD----------------SF 1244

  Fly   668 QHYTPFLMRSWVKFLTVMGFLAALISSLYASTR---LQDGLDIIDLVPKDSNEHKFLDAQTRLFG 729
            ::.|                   ..|.|  |.|   |.|.:....|.||...:...::|.:.
Zfish  1245 ENST-------------------CTSKL--SNRPSVLSDDIQFCGLSPKQDYDRVSIEADST--- 1285

  Fly   730 FYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEY 794
              .|.:........|...|....|.::.:|:|                             .:..
Zfish  1286 --EMCSRHLKGCNPPPALQTSSPYKENMLRLP-----------------------------QDAC 1319

  Fly   795 RDGRLTKEC----------WFPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIINQR 849
            ::..|.|:|          |..:.||.:.:...:|.||....|         .|.::.|..|::|
Zfish  1320 KEKVLCKKCRGQSRGGLQLWNVSLSSSSSMDEIMITQTTDTVN---------ERSLSMDDHIHKR 1375

  Fly   850 AFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYDLKIPKSLPLVYAQMPFYLHGLTDTSQ 914
                .||..:.:.:.....|.....          .|.:..||::..:.....|.:|:|..||.:
Zfish  1376 ----LLSCQSQSSIEGLEESNDTCL----------TEVEAAIPQAGKIEDEFQPGHLNGKRDTLR 1426

  Fly   915 IKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLAMIL 960
                      ||:|...:.|.:..||       :..|.:|.:.:||
Zfish  1427 ----------LSLKETVYDLASPGSG-------RVRTAQSDVPVIL 1455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	190/1021 (19%)
ptc	NP_523661.2	MMPL	454..598	CDD:304422	34/153 (22%)
disp2	XP_005158826.1	MMPL	517..660	CDD:304422
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589938
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930