Protein Alignment ptc and Ptch2

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: NP_001102445.2
• Gene: Ptch2 / 366452
• RGDID: 1309039
• Length: 1182
• Species: Rattus norvegicus
• Alignment Length: 1244
• Identity: 455/1244 - (36%)
• Similarity: 682/1244 - (54%)
• Gaps: 154/1244 - (12%)

  Fly    48 GSRTA-IYLRSVFQSHLETLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIHSKVHQLWIQEGGR 111
            ||..| ::||:.||..|.:||..:|||.|||||:.::.|....:||:.|.|.:.:.|||::.|.|
  Rat    28 GSLQAPLWLRAYFQGLLFSLGCRIQKHCGKVLFLGLVALGALALGLRVAVIETDLEQLWVEVGSR 92

  Fly   112 LEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDTEWGLR 176
            :..||.||::.:||:.:.|.|:||||.....|::|.|:||..||:..:.|:.|:|.||...|.|.
  Rat    93 VSQELHYTKEKLGEEAAYTSQMLIQTARQEGANILTPEALGFHLQAALTASKVQVSLYGKSWDLN 157

  Fly   177 DMCNMPSTPSFE-GIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQRLLWTTLN 240
            .:|.....|..| |:  ||:::..|.||.|:|||||||||::|.|  .:..:|| ...:.||.|:
  Rat   158 KICYKSGVPLIENGM--IERMIEKLFPCVILTPLDCFWEGAKLQG--GSAYLPG-RPDIQWTNLD 217

  Fly   241 PASVMQYMKQKMSEEKISF-DFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNKNSTQPPD 304
            |        |::.||...| ..|...:.:.:|.:|..|:.:|||:|.:|:||.:|||::|.|.|:
  Rat   218 P--------QQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLDPDDPHCPPSAPNRHSRQAPN 274

  Fly   305 VGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVH 369
            |...|||||:|::.|.|||.|||::||..|:..|.|.:|:|.||...||:.:::|:.::.:|:.|
  Rat   275 VAQELSGGCHGFSHKFMHWQEELLLGGTARDLQGQLLRAEAFQSTFLLMSPRQLYEHFRGDYQTH 339

  Fly   370 HLGWTQEKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVI 434
            .:||::|:|:.||.||||.|.:..::.|...:    :..|:.|||..|||||..||..||..:|.
  Rat   340 DIGWSEEQASMVLQAWQRRFVQLAQEALPANA----SQQIHAFSSTTLDDILQAFSEVSATRVVG 400

  Fly   435 GVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLAL 499
            |..:.:.||..|:||| |..:.|.:||:|||||:..:.|:||||.|||||.||||:|||:|||||
  Rat   401 GYLLMLAYACITMLRW-DCAQSQGAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLAL 464

  Fly   500 GLGVDHIFMLTAAYAESNRR----EQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCL 560
            |:|||.||:|..|:.::...    |:....|::.|.|:..::.:...:||.|..:|:|||:.|.|
  Rat   465 GIGVDDIFLLAHAFTKAPPNTPLPERMGECLRRTGTSVALTSINNMVAFFMAVLVPIPALRAFSL 529

  Fly   561 QAAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGA- 624
            |||||:..|.||.:|||||::|||||||...|.|:.||.     ..|..|..:..|....|..|
  Rat   530 QAAIVVGCNFAAVMLVFPAVLSLDLRRRHRQRLDVLCCF-----SSPCSAQVIQMLPQELGDRAV 589

  Fly   625 --------------RHPKSCNNNRVP-LPAQNPLLEQRAD-------IPGSS------------- 654
                          .|.::.:.:.|. ||.|..||...:|       .||.|
  Rat   590 PVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLLSPTSDPLGSELYSPGGSTRDLLGQEEGTRP 654

  Fly   655 ----HSL--ASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPK 713
                .||  |.::||.||...:.|.|:::..|.|.::.|.|.|..|||.:|.:||||.:.|:||:
  Rat   655 KASCRSLLCAHWTLAHFARYQFAPLLLQTQAKALVLLFFGALLGLSLYGATLVQDGLALTDVVPR 719

  Fly   714 DSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLL 778
            .:.||.||.||.|.|..|.:..||||.|:|...|:.|.|.|..|..:..|:.......|..||..
  Rat   720 GTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPAAQAPRTWLHY 784

  Fly   779 FSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSD 843
            :..||..:|..||:::..||:|:.. :.|.|.|..|||||::|||:...|:|...:.|.:||:.:
  Rat   785 YRSWLQGIQTAFDQDWASGRITRNS-YRNGSEDGALAYKLLIQTGNAQEPLDFNQLTTRKLVDKE 848

  Fly   844 GIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYD-----LKIPKSLPLVYAQMP 903
            |:|....||..|:.|.::|.....|||...||.|.::.|  ::||     |:||.:.||.:||.|
  Rat   849 GLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLH--DKYDTTGENLRIPAAQPLEFAQFP 911

  Fly   904 FYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAAL 968
            |.||||..|:.....|...|....:....|:..||||.||:|||||:.||....:.:..:||...
  Rat   912 FLLHGLQKTADFVEAIEGARAACTEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLLCTF 976

  Fly   969 VLVSLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFM 1033
            ::.:||||:.|.|.|::|.:.....::||.|..|||||||||.|||:.|||:.:.|.|.::|||:
  Rat   977 LVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFL 1041

  Fly  1034 TSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLV 1098
            ||.|:|..|...:::.:..|:..|.:::.:.:.||:.|.|:|:||:|..:|.|:..:|..:.||:
  Rat  1042 TSHGSRNLRAARALEQTFAPVTDGAVSTLLGLLMLAGSNFDFIIRYFFVVLTVLTLLGLLHGLLL 1106

  Fly  1099 FPILLSMVGPEAELVPL--EHPDRISTPSPLPVRSSKRSGKSYVVQGSRSSRGSCQKSHHHHHKD 1161
            .|:|||::||..::|.:  |.|..:|:.:|      :|.|..:.|
  Rat  1107 LPVLLSILGPPPQVVQIYKESPQALSSTAP------QRGGLRWGV-------------------- 1145

  Fly  1162 LNDPSLTTITEEPQSWKSSNSSIQMPNDWTYQPREQRPASYAAPPPAYHKAAAQQHHQHQGPPTT 1226
              .|:|      |||:....:|:.:                     |.|
  Rat  1146 --SPTL------PQSFARVTTSMTV---------------------ALH---------------- 1165

  Fly  1227 PPPPFPTAY 1235
             |||.|.||
  Rat  1166 -PPPLPGAY 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	438/1141 (38%)
		MMPL	454..598	CDD:304422	73/147 (50%)
Ptch2	NP_001102445.2	Patched	12..1142	CDD:355433	440/1145 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1190129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105508
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840