Protein Alignment ptc and Ptr

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: NP_001246145.1
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Alignment Length: 1057
• Identity: 213/1057 - (20%)
• Similarity: 372/1057 - (35%)
• Gaps: 292/1057 - (27%)

  Fly   323 WPEEL---IVGGAKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNA 384
            |...|   ..||.|.....::....|:|.|..:..:.:..|               .|.||
  Fly   183 WDAHLFPVFFGGTKLTEDNYVISVPAIQLVYFVTADTKRQD---------------AKGAE---- 228

  Fly   385 WQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDILAK-----FSHPSALSIVIGVAVTVLYAF 444
            |:..|.|.|..  .:.|....:..:..|:|..||..|.|     ..:.|:..:::|     |::.
  Fly   229 WEETFLRVVGN--AENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMG-----LFSI 286

  Fly   445 CTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVF---NAASTQVVPFLALGLGVDHI 506
            .|.: ..|.||.:..:|:.|.:....:|.|..||:...||.|   |.|:    |||.:|:|:|..
  Fly   287 ITCM-MGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAA----PFLMIGIGIDDT 346

  Fly   507 FMLTAAYAESNRR----EQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMC 567
            |::.|.:..:..:    |:..|::.:...||..::.:...||......|..::::||..:...:|
  Fly   347 FVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVC 411

  Fly   568 SNLAAALLVFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNN----------NGR 622
            ......:..|.|.:::...|.......||.|         :|.|..:.:...          .|.
  Fly   412 FTFLWHITFFAACMAISGYRERKNLHSIFGC---------RVQPMSVAIKEKRNFLYKAIMAGGI 467

  Fly   623 GARHPKSCNNNRVPLPAQNPLLEQRADIPGSSHSLASFSLATFAFQHYTPFLMRSWVKFLTVMGF 687
            .|..|            .||       |....|.|.:|.....|     ..:...|.|.:.::.|
  Fly   468 DANDP------------DNP-------IDNKDHMLMAFFKDKMA-----AVINNKWCKAIIILAF 508

  Fly   688 LAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQT---RLFGFYSMYAVTQG--NFEYPTQQ 747
            .:.|:.:.|..|::::||:...|..:||...:|.|.:.   |.|. |.|..:..|  |:..|..|
  Fly   509 ASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFP-YRMQVIIAGPLNYSDPLVQ 572

  Fly   748 QLLRDY-----HDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGN----LQKIFDEEYRDGRLTKEC 803
            :.:.:.     |.|:|......::        ||..|..:|..    |....|:|.......||.
  Fly   573 EQVENLTSTLEHTSYVTSRRYTES--------WLRSFLSFLERNNELLNVTVDDEQTFIDAVKEH 629

  Fly   804 W-FP----------NASSDAILAYKLIVQTGHV-DNPVDKELVLTNRLVNSDGIINQRAFYNYLS 856
            | ||          |.....|:|.:.::|..:: |...:||:|...|.:..|..:|...|:.|
  Fly   630 WLFPGNPFSLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKDSPLNASIFHPY-- 692

  Fly   857 AWATNDVFAYGASQGKLYPEPRQYFHQPNEYDLKIPKSLPLVYAQMPFYLHGLTDTSQIKTLIGH 921
                                                                             
  Fly   693 ----------------------------------------------------------------- 692

  Fly   922 IRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLR--SSLAMILACV--LLAALVLVSLLLLSVWAAV 982
                                 |:|::|:..:|  |..||::..:  ::.:.|.:..:|.|:|.|
  Fly   693 ---------------------FVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVA- 735

  Fly   983 LVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGNRQR-RVQLS 1046
               .||::....:.|.|.|..:.|.:|..:.||:.:|..:.|...|...:|:|.....: ||:.:
  Fly   736 ---FSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREA 797

  Fly  1047 MQMSLG-PLVHGMLTS--GVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGP 1108
            :. ||| |::.|..::  |:...:|:.|   ::...|..::.:|:..||.:.|.:.|:|||:.||
  Fly   798 LH-SLGLPIIQGSSSTILGIVALLLAQS---YIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGP 858

  Fly  1109 EAELV--------PLEHPDRISTPSPLPVRSSKRSGKSYVVQ----------GSRSSRGSCQKSH 1155
            .:.|.        ..|..|.:...     :..|...:||.:|          ||:...|:..|::
  Fly   859 GSCLTWTGKDDGSDAEVDDGLDDR-----QLEKPFSQSYYMQYPSIGINGPYGSKGFLGAPYKAY 918

  Fly  1156 HHHHKDLNDPSLTTITEEPQSWKSSNS-------------------SIQMPNDW---TYQP-REQ 1197
            ....|||   .|.|..|:.....||.|                   :.:..:.|   :||. ..|
  Fly   919 GVDEKDL---GLGTSGEDSSESSSSRSQHRQQAAATEEEVVVRESPTRRYDDGWRRSSYQNIYGQ 980

  Fly  1198 RPASYAAPPPAYHKAAA--------QQHHQHQGPPTTPPPPFPTAYPPELQSIVVQPEVTVETTH 1254
            ..|.:.|.|..|.|..:        ..|.|.|.......|     :....|.:.:..:.....:|
  Fly   981 GAAQFQAQPDLYGKQVSATEWRQRLDTHEQQQRQRQRRSP-----FENYRQDVEIDMQKARRNSH 1040

  Fly  1255 SDSNTTKVTATANIKVE 1271
            .|  ...:..|.|..||
  Fly  1041 GD--VIDLHGTPNSSVE 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	176/877 (20%)
		MMPL	454..598	CDD:304422	36/150 (24%)
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	166/830 (20%)
		Sterol-sensing	295..442	CDD:289145	36/150 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460578
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840