DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ptc and Ptchd1

DIOPT Version :9

Sequence 1:	NP_523661.2	Gene:	ptc / 35851	FlyBaseID:	FBgn0003892	Length:	1286	Species:	Drosophila melanogaster
Sequence 2:	NP_001178663.1	Gene:	Ptchd1 / 317517	RGDID:	1564527	Length:	888	Species:	Rattus norvegicus

Alignment Length:	1020	Identity:	201/1020 - (19%)
Similarity:	366/1020 - (35%)	Gaps:	316/1020 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 YYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQRLLWTTLNPASVMQYMKQKMSEE 255
            |.:|:.:.|                  ||.|:.::   ...:|.|..:|.|.:        .|:.
  Rat    46 YQVEESVEH------------------LLAPQHSL---AKIERNLVNSLFPVN--------RSKH 81

  Fly   256 KISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPD------TAPNKNSTQPPDVGAILSGGCY 314
            ::..|.:|..:|.:  .|.:.|.:   .|.|:.:..|      ||..|  .|.|..|       :
  Rat    82 RLYSDLQTPGRYGR--VIVTSYQK---ANMLDQHHTDLILKLHTAVTK--IQVPRPG-------F 132

  Fly   315 GYAAKH---------------MHWPEELIVGGAKRNRSG--------HLRKAQALQSVVQLMTEK 356
            .|...|               :|..||| ......||:.        ||:..:|:
  Rat   133 NYTFAHICVLNNDKTCIVDDIVHVLEEL-KNARATNRTNFAITYPITHLKDGRAV---------- 186

  Fly   357 EMYDQWQDNYKVHHLGWT------QEKAAE-----------------VLNAWQRNFSREVEQLLR 398
                     |..|.||..      :.|:||                 |...|:.:|...|:...:
  Rat   187 ---------YNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVKLFQK 242

  Fly   399 KQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVIGVAVTVLYAF--CTLLRWRDPVRGQSSVG 461
            ..|::    .||.::|::|.:...|.|..|...:|..:.:.|..|.  |::   :|.||.:..:|
  Rat   243 SNSKV----KIYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSM---QDCVRSKPWLG 300

  Fly   462 VAGVLLMCFSTAAGLGLSALLGIVFNAASTQV-VPFLALGLGVDHIFMLTAAYAESNRREQTKLI 525
            :.|::.:..:|....|:..|.|..:|  ||.: |||:.||.|:...|.:.:::.::...:..|..
  Rat   301 LLGLVTISLATLTAAGIINLTGGKYN--STFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHVKER 363

  Fly   526 LKKVGPSILFSACSTAGSFF------AAAFIPVPALKVFCLQAAIVMCSNLAAAL------LVFP 578
            ..:|....:.|...|...:.      |:.|..:.|.::||..:.|.:..|....|      |||.
  Rat   364 TAEVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAILFNYLYVLSFYGSSLVFT 428

  Fly   579 AMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPL 643
            ..|..:.:.      .|||      ::.||  |.||.                    ..||....
  Rat   429 GYIENNYQH------SIFC------RKVPK--PEVLQ--------------------EKPAWYRF 459

  Fly   644 L------EQRADIPGSSHSLASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQ 702
            |      |..|: ...:::..|..|..|..::|..::..::||...|:.:|..:..:|....::.
  Rat   460 LLTARFSEDTAE-GEEANTYESHLLVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVS 523

  Fly   703 DGLDIIDLVPKDSNEHKFLDAQTRLF-------GFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRV 760
            :|.|:.::|...:...::..|..:.|       |||...::...|..  .|:.:| :|...|||:
  Rat   524 EGSDLSNIVATATQTIEYTTAHQKYFNNYSPVIGFYIYESIEYWNSS--VQEDVL-EYTKGFVRI 585

  Fly   761 PHVIKNDNGGLPDFWLLLFSEWLGNLQKI----------FDEEYRDGRLTKECWFPNASSDAILA 815
            .             |   |..:|..|:|:          |.:..|:..| |...|.:...|.|.:
  Rat   586 S-------------W---FESYLNYLRKLNVSTDLPKKNFTDMLRNSFL-KAPQFSHFQEDIIFS 633

  Fly   816 YKLIVQTGHVDNPVDKELVLTNR--LVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPR 878
            .|       .::.||   |:.:|  ||......|:...|:.|..
  Rat   634 KK-------YNDEVD---VVASRMFLVAKTMETNREELYDLLET--------------------- 667

  Fly   879 QYFHQPNEYDLKIPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPF 943
                                       |..|:.||::|.::.:                ||   |
  Rat   668 ---------------------------LRRLSVTSKVKFIVFN----------------PS---F 686

  Fly   944 IFWEQYMTLRSSLAMIL--ACV-----LLAALVLVSLLLLSVWAAVLVILSVLASLAQIFGAMTL 1001
            ::.::|   .|||...|  :|:     |..:..||:..|::||    :.|:|::....:.|.|||
  Rat   687 VYMDRY---ASSLGAPLHNSCISALFLLFFSAFLVADSLINVW----ITLTVVSVEFGVIGFMTL 744

  Fly  1002 LGIKLSAIPAVILILSVGMML--CFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVA 1064
            ..::|..|..:.||..:...:  | ..|:|...:.....|.:.|:.::::....::...|...|.
  Rat   745 WKVELDCISVLCLIYGINYTIDNC-APLLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVG 808

  Fly  1065 VFMLSTSPFEFVIRHF-CWLLLVVLCVGACNSLLVFPILLSMVGP 1108
            :|.|:..|.......| |..|:..:....|.::|  |::|:.:.|
  Rat   809 LFPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAIL--PVILTFLPP 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	201/1020 (20%)
ptc	NP_523661.2	MMPL	454..598	CDD:304422	36/156 (23%)
Ptchd1	NP_001178663.1	Patched	105..851	CDD:280598	184/925 (20%)
Ptchd1	NP_001178663.1	MMPL	292..443	CDD:304422	37/164 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348793
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840