DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ptc and Disp3

DIOPT Version :9

Sequence 1:	NP_523661.2	Gene:	ptc / 35851	FlyBaseID:	FBgn0003892	Length:	1286	Species:	Drosophila melanogaster
Sequence 2:	NP_001101462.2	Gene:	Disp3 / 313705	RGDID:	1305820	Length:	1351	Species:	Rattus norvegicus

Alignment Length:	1105	Identity:	200/1105 - (18%)
Similarity:	343/1105 - (31%)	Gaps:	372/1105 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 QPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHL-------RKAQALQSVVQLMTEKEM 358
            :|.:|...|..|.|.|.:.    |..|:.......|.|.:       ..|....|:...||..|.
  Rat   276 KPHEVLKDLPLGSYSYCSP----PSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEF 336

  Fly   359 YDQWQ-------DNYKVHHLGWTQEKAAEVL------------NAWQ------RNFSREVEQLLR 398
            |  |.       ||.|...|      .:|:|            :.|:      ::|......:|.
  Rat   337 Y--WYVDEGLSVDNLKSSLL------RSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLA 393

  Fly   399 KQ--SRIATNY---DIYVFSSAAL--DDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRG 456
            ||  |::...|   |::.:.....  :|:|..|...|.::     |:..:...|::.
  Rat   394 KQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIA-----ALVYILTSCSVF-------- 445

  Fly   457 QSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYAESNRREQ 521
            .|..|:|.:.|.|.  .|......:.||.:......|..|:.:|:|||.:|:....|.::...|.
  Rat   446 LSFFGIASIGLSCL--VALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLED 508

  Fly   522 TKL----ILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMIS 582
            .:|    .::..|.:..|::.:||.::.|..|..:||:..|.|..::::.....|.|...||.:.
  Rat   509 PQLRMIHTIQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVTCCWLAVLFTMPAALG 573

  Fly   583 LDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPL---------- 637
            |                   |...      |.|| .::.:.:.|.|....:.:..
  Rat   574 L-------------------WSLY------VAPL-ESSCQSSCHQKCGRKSSLHFPGDLFTAPER 612

  Fly   638 ----PAQNPLLEQRADIP-------GSSHSLASFSLATFAFQHYTPF---------------LMR 676
                |||.||.....|||       ..|..|...||.:...:...|.               |:.
  Rat   613 AGCGPAQGPLPYLDDDIPLLNVEDEPVSLELGDVSLVSVHCEGLQPTPDGNSRGQLLAQLQELLH 677

  Fly   677 SWVKFLTVMG-------FLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFG----- 729
            .||.:..|..       |.:.||.||..::||:.......|...|:|....||.:..|..
  Rat   678 RWVLWAAVKSRWVIVGLFASILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISC 742

  Fly   730 ------FYSMYAVTQGNF-------------------EYPTQQQLLRDY--------HDSFVRVP 761
                  |.......|.|.                   |...|:.:...|        |.:..|:.
  Rat   743 ITCSGLFQEKPHSLQNNVRTSLEKKKRGSGVSWASRPETTAQESMSTVYISKVKSKGHPAVYRLS 807

  Fly   762 ---------HVIKNDNGGLPDF------------------------------------------- 774
                     ..:...:|.:|.|
  Rat   808 LNASLPAPWQAVSPGDGEVPSFQVYRAPFGDFTKKLTACMSTVGLLQAASPSRKWMVTALACDAR 872

  Fly   775 --WLLLFSEWLGNLQK------IFDEEYR---DGRL----------------TKECWF------P 806
              |...||.::...::      .|.:.::   .|||                ||..::      |
  Rat   873 RGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRLCVAPPGCLLSSSPDGPTKGFFYVPSDRVP 937

  Fly   807 NASSDAILAYKLIVQTGHVDNPVDKELVLT-------------NRLVNSDG-IINQRAFYNYLSA 857
            .|...|...:...|.|| ...|..:.||.|             ||....|. :|.......|.|:
  Rat   938 KARISATFGFNPCVNTG-CGKPAVRPLVDTGAMVFVVFGIIGINRTQQMDNHVIGDPGSVIYDSS 1001

  Fly   858 W-----------------ATNDVFAYGASQ----GKLYPEPRQYFHQPNEYDLKIPKSLPLVYAQ 901
            :                 ..:::...|.:|    |.......|..| |...:|..|..||   .|
  Rat  1002 FDLFKEIGHLCRLCKAIAGNSELVKPGGAQCLPSGYSISSFLQMLH-PECKELPEPNLLP---GQ 1062

  Fly   902 MPFYLHGLTDTSQIKTLIGHIRDLSVKYEGF---GLPNYPSGIPFIFWEQYM------------- 950
            :.   ||.....:     |.::.:|:.:|..   |..::.:...::.||.::
  Rat  1063 LS---HGAVGVKE-----GRVQWISMAFESTTYKGKSSFQTYSDYLRWESFLRQQLQTFPEGSAL 1119

  Fly   951 ----------------------TLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLA 993
                                  .|...:..:|.||...|:....:|||     :.|:||:|..:.
  Rat  1120 RRGFQTCEHWKQIFMEIIGVQSALYGLVLSLLICVAAVAVFTTHVLLL-----LPVLLSILGIVC 1179

  Fly   994 QIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGN------------RQRRVQLS 1046
            .:...|...|.::.|:.|:.|.:.||..:.:.|.:..|::.:..|            ||.|...:
  Rat  1180 LVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPQQAEDASSQRQWRTLEA 1244

  Fly  1047 MQMSLGPLVHGMLTSGVA---VFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGP 1108
            ::.....:|...||:.:|   :|....:||    ..|..::.:...|....:|.|...||.::.|
  Rat  1245 VRHVGVAIVSSALTTVIATVPLFFCIIAPF----AKFGKIVALNTGVSILYTLTVSTALLGIMAP 1305

Fly 1109 1108
Rat 1306 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	200/1105 (18%)
ptc	NP_523661.2	MMPL	454..598	CDD:304422	33/147 (22%)
Disp3	NP_001101462.2	COG1033	<375..>572	CDD:223964	45/211 (21%)
Disp3	NP_001101462.2	COG1033	<1130..>1300	CDD:223964	36/178 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348790
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930