Protein Alignment ptc and Disp2

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: NP_001101229.2
• Gene: Disp2 / 311324
• RGDID: 1309569
• Length: 1346
• Species: Rattus norvegicus
• Alignment Length: 1347
• Identity: 257/1347 - (19%)
• Similarity: 415/1347 - (30%)
• Gaps: 486/1347 - (36%)

  Fly   110 GRLEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDTEWG 174
            ||.|..:..|::.:|.         ::...:.|.....|:..||.| |.|..:...:      |.
  Rat   208 GRAEESVVRTKRMVGP---------VEVKEEENFFCGPPEKKLAKL-VFVSTSGGSL------WN 256

  Fly   175 LR---DMCNMPSTPSFEGIYYIEQILRHL---IPCSIITPLDC--FWEGSQLLGPESAVVIPGLN 231
            |:   .||.:..          |||..|:   ..|......:|  .|.    ||...||
  Rat   257 LQAIHSMCRIEQ----------EQIRSHISFGALCQRSAANECCPSWS----LGNYLAV------ 301

  Fly   232 QRLLWTTLNPASVMQYMKQKMSEEKISFDFETVEQYMKR-----AAIGSGYMEKPCLNPLNPNCP 291
                   |:..|..|...|..::..::. ......:..|     |.:||| .:||      |.|.
  Rat   302 -------LSNRSSCQDTTQADTDRTLAL-LRFCATFYHRGVLVPACVGSG-QDKP------PFCA 351

  Fly   292 DTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEK 356
            . .|.|               |.|                           :.|:..::..:.::
  Rat   352 Q-VPAK---------------CTG---------------------------SSAVYQLLHFLLDR 373

  Fly   357 EMYDQWQDNYKVHHLGWTQ-----EKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFSSAA 416
            :.......:|:|..|.:..     .|.:.:|:.:.......:        :::.||.........
  Rat   374 DFLSPQTADYQVPSLKFALLFLPIIKTSSLLDIYLDGLGDPI--------KVSDNYTSISGMDLG 430

  Fly   417 LDDILAKF------SHPSALSIVI---GVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFST 472
            |...|.|:      .:| .||:||   |:::.:...|.|.:         |.:||.|.|::.|
  Rat   431 LKPRLLKYYLAEDTMYP-LLSLVIIFFGMSLYLRSLFITFM---------SLLGVLGSLMVAF-- 483

  Fly   473 AAGLGLSALLGIVFNAASTQVVPFLAL-------GLGVDHIFMLTAAYAESNRREQTKLILKKVG 530
                   .|..:.|..|   ..||:.|       |:.|::..:....:..|..:..:..:..:||
  Rat   484 -------FLYHVAFRMA---YFPFVNLASLLLLSGVCVNYTLIFFDLWRLSRGQVPSGGLAHRVG 538

  Fly   531 PS-------ILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLRRR 588
            .:       :|.|..:|:.:|:.:....:|.::.|.|.....:..::...||..||.:.|..|..
  Rat   539 RTMHHFGYLLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVHMGLTLLWLPATVVLHERYL 603

  Fly   589 TAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRADIPGS 653
            ..|       |....:.|               ||...|.     |:.|     .|.:|..|...
  Rat   604 AHG-------CVAQAQGQ---------------RGGSDPL-----RLLL-----ALHRRIRILRK 636

  Fly   654 SHSLASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLY---ASTRLQDGLDIIDLVP--- 712
            ..|:    |:...||...|..:..: :::.:..|.|......|   .|.||:  |.|  |:|
  Rat   637 IFSI----LSRLLFQRLLPCGVIKF-RYIWICWFAALAAGGAYIGGVSPRLR--LPI--LLPLGG 692

  Fly   713 ---KDSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDF 774
               :.|:..:..||:.|                   ||.|..|       :|   .|:.|.||
  Rat   693 QFFRSSHPFERFDAEYR-------------------QQFLFED-------LP---PNEGGNLP-- 726

  Fly   775 WLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLI-VQTGHVDNPVDKELVLTNR 838
                                                 .:|.:.:: |.|   .:|:|..   ||.
  Rat   727 -------------------------------------VVLVWGILPVDT---SDPLDPR---TNS 748

  Fly   839 LVNSD-------------------GIINQRAFYNYLSAWAT------NDVFAYGASQGKL----- 873
            .|.||                   |..||..|.:....|.|      ...:....|.|:|
  Rat   749 SVVSDPDFSPSSPEAQEWLQALCQGAQNQSFFGDQPEGWPTLCLVEALQQWMESPSCGRLGADLC 813

  Fly   874 -----YP-EPRQYFH---------QPN-------EYD---------LKIPKSLPLVYAQMPFYLH 907
                 :| .|:.|.|         .|:       .:|         ||...:||......|.: |
  Rat   814 CGQSEFPWAPQLYLHCLKMMALEQSPDGTRDLGLRFDSHGNLAALVLKFQTNLPYSTEYGPVH-H 877

  Fly   908 GLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIP---FIFWEQYMTLRSSLAMILACVLLAALV 969
            ..|:.|         |.||.:     :...|.|:.   |....:..:|:.||:...|.||..||.
  Rat   878 FYTEVS---------RWLSTE-----MSKAPPGLNKGWFTSTLELYSLQHSLSTEPAVVLGLALA 928

  Fly   970 LV-SLLLLSVWAAVLVILSVLASLAQIF---GAMTLLGIKLSAIPAVILILSVGMMLCFNVLISL 1030
            |. :.|||..|...|.:.||.|....:.   |.:.||..:|:...|:.|..|||:.:...|...:
  Rat   929 LAFATLLLGTWNVPLSLFSVAAVAGTVLLTVGLLVLLEWQLNTAEALFLSASVGLSVDLTVNYCI 993

  Fly  1031 GF-MTSVGNRQRRVQLSMQMSLGPLVHG---MLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVG 1091
            .: :....:|..||..|::.:......|   :..||| :.:.||.   .:.|....::::|..:|
  Rat   994 SYHLCPHPDRLSRVAFSLRQTSRATAMGTGVLFASGV-IMLPSTI---LLYRKLGIIVMMVKFLG 1054

  Fly  1092 ACNSLLVFPILLSMVGPEAE----LVPLEH---------PD---RISTP--------SPLPVR-- 1130
            ...:...|..|....|||..    |.|..|         ||   |...|        .||..|
  Rat  1055 CGFASFFFQSLCCFFGPEKNCGQILWPCAHLPWDAGTEDPDEKGRTGPPGFSEHYELQPLARRRS 1119

  Fly  1131 --------SSKRSGK-SYVVQGSRSSRGSCQKSH------------HHHHKDLNDPSLTT----- 1169
                    :||.|.: |.:.:..:...|||...|            .|.......|:|.|
  Rat  1120 PSFDTSTATSKLSHRPSILSEDLQIHDGSCCLQHAQVPVSPRDLLLDHQTVFSQCPALQTSSPYK 1184

  Fly  1170 -ITEEPQSWKSSNSSIQMPNDWTYQPREQRPASYAAPPPAYHKAAAQQHHQHQGPPTTPPPPFPT 1233
             :...||:|...:|..|..     :|.:..|                     :||...|.|....
  Rat  1185 QVGPNPQTWIRQDSQGQKT-----EPLQALP---------------------EGPAHCPKPKVME 1223

  Fly  1234 AYPPEL--------------------------QSIVVQPEVTVETTH 1254
            ..|..|                          .|:...|||...|.|
  Rat  1224 ELPDGLCSSASTLEGLSVSDDTCASEPSVRVPDSVGTSPEVMNGTGH 1270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	227/1180 (19%)
		MMPL	454..598	CDD:304422	31/157 (20%)
Disp2	NP_001101229.2	MMPL	<448..598	CDD:419723	35/170 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348787
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930