Protein Alignment ptc and ptch2

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: NP_571063.2
• Gene: ptch2 / 30181
• ZFINID: ZDB-GENE-980526-44
• Length: 1442
• Species: Danio rerio
• Alignment Length: 1422
• Identity: 483/1422 - (33%)
• Similarity: 756/1422 - (53%)
• Gaps: 205/1422 - (14%)

  Fly     7 PRVPDTHGDVVDE----------KLFSDLYIRTSWVDAQVALDQIDKGKARGSRTAIYLRSVFQS 61
            ||.|...|.|..:          .:.|||..|.|:..|..||.||.||||.|.:..:::|:.||:
Zfish     5 PRDPGPAGGVFGDLPPSYTRSPPPVNSDLLRRPSYCHAAFALKQISKGKAVGQKAPLWIRARFQA 69

  Fly    62 HLETLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIHSKVHQLWIQEGGRLEAELAYTQKTIGED 126
            .|.:||..:|:|.|||||:.:||.....|||:.|.|.:.:.:||::.|.|:..||.||::..||:
Zfish    70 FLFSLGCHIQRHCGKVLFIGLLVFGALSVGLRVAAIETDIEKLWVEAGSRVSKELRYTKEKQGEE 134

  Fly   127 ESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFEGIY 191
            ...|.|:||||......::|..:|||.|||..:.|:.|:|.||...|.|..:|.....|..|.:
Zfish   135 SVFTSQMLIQTPKQEGTNILTQEALLLHLEAALSASKVQVSLYGKSWDLNKICFKSGVPIIENV- 198

  Fly   192 YIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQRLLWTTLNPASVMQYMKQKMSEEK 256
            .||:::..|.||.|:||||||||||:|.|  .:..:||:.. :.|..|:|..:|:.:.|..|
Zfish   199 MIERMIDKLFPCMIVTPLDCFWEGSKLQG--GSAYLPGMPD-IQWMNLDPLKLMEELSQFTS--- 257

  Fly   257 ISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKHM 321
                .|...:.:.:|.:|..||.:|||:|.:.:||.:||||:..|.|::.|.|.|||:|::.|.|
Zfish   258 ----LEGFREMLDKAQVGHAYMNRPCLDPSDTDCPHSAPNKDPWQVPNIAAELQGGCHGFSKKFM 318

  Fly   322 HWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNAWQ 386
            ||.||||:|...::....|:.|:|||::..||:.|::|:.::|:|::|.:.|.::||..:|.:||
Zfish   319 HWQEELILGERVKDSQNALQSAEALQTMFLLMSPKQLYEHFKDDYEIHDINWNEDKATAILESWQ 383

  Fly   387 RNFSREVEQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWR 451
            |.|...|...:.:.|    :.::|.||:..|:||:..||..|.:.:..|..:.:.||..|:|||
Zfish   384 RKFVEVVHGSIPQNS----SSNVYAFSTTTLNDIMKSFSDVSVIRVAGGYLLMLAYACVTMLRW- 443

  Fly   452 DPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYAES 516
            |..:.|.:||:|||||:..|.||||||.:|||:.||||:|||:||||||:|||.:|:|..::.|:
Zfish   444 DCAKSQGAVGLAGVLLVALSVAAGLGLCSLLGLSFNAATTQVLPFLALGIGVDDMFLLAHSFTET 508

  Fly   517 NR----REQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVF 577
            ..    :|:|...|::.|.|:..::.:...:||.||.:|:|||:.|.||||:|:..|.|..||:|
Zfish   509 RSNIPFKERTGDCLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIF 573

  Fly   578 PAMISLDLRRRTAGRADIFCCCF-PVWKEQPKVAPPVL-PLNNNNGRGARHPKSCNNN------- 633
            ||::||||.||...|.||.||.: |......::.|..| ..|:|:.|....|....:.
Zfish   574 PAILSLDLHRREDKRLDILCCFYSPCSSRVIQIQPQELSDANDNHQRAPATPTYTGSTITTSTHI 638

  Fly   634 ------------------------------------RVPLPAQNPLLEQRADIPGSSHSLAS--- 659
                                                ..|.|..:|...|......|:..|.:
Zfish   639 TTTVQAFTQCDAAGQHIVTILPPTSQISTTPPSMVLSTPTPTTDPYGSQVFTTSSSTRDLLAQVE 703

  Fly   660 ---------------FSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIID 709
                           ::|::||.:.|.|.|::...|.:.|:.|:|.|..|||.:|.:.|||.:.|
Zfish   704 EPKEGRECVPLPFFRWNLSSFAREKYAPLLLKPETKTVVVVVFVALLSLSLYGTTMVHDGLYLTD 768

  Fly   710 LVPKDSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDF 774
            :||:|:.|::|:.||.:.|.||:||.||...|:|...|:.|...|::|..|.:|:|:.|..||..
Zfish   769 IVPRDTQEYEFITAQFKYFSFYNMYLVTMDGFDYARSQRQLLQLHNAFNSVKYVVKDGNHKLPRM 833

  Fly   775 WLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRL 839
            ||..|.:||..||..||.::..|::|.:. :.|.:.|..|||||::|||....|.:...:.:.||
Zfish   834 WLHYFQDWLKGLQATFDADWEAGKITYDS-YRNGTEDGALAYKLLIQTGSKKEPFNYSQLTSRRL 897

  Fly   840 VNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYD-----LKIPKSLPLVY 899
            |:.||:|....||.||:.|.:||...|.|||...||.||::.|  ::||     |:||.:.||.:
Zfish   898 VDEDGLIPPEVFYIYLTVWVSNDPLGYAASQANFYPHPREWIH--DKYDTTGENLRIPAAEPLEF 960

  Fly   900 AQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRS----SLAMIL 960
            ||.||||:||...|.....|..:|.:..::...|:.|||:|.||:|||||:.||.    |::::|
Zfish   961 AQFPFYLNGLRQASDFIEAIESVRTICEEFMRQGIKNYPNGYPFLFWEQYIGLRHWFLLSISVVL 1025

  Fly   961 ACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFN 1025
            ||..|    :.::|||:.|.|.:::..:.....::||.|.|:||||||||.||||.|||:.:.|.
Zfish  1026 ACTFL----VCAILLLNPWTAGVIVFILAMMTVELFGIMGLIGIKLSAIPVVILIASVGIGVEFT 1086

  Fly  1026 VLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCV 1090
            |.|:|||:|::|:|..|..::|:....|::.|.:::.:.|.||:.|.|:|::|:|..:|.::..:
Zfish  1087 VHIALGFLTAIGDRNTRSAVAMEHMFAPVIDGAISTLLGVLMLAGSEFDFIMRYFFAVLAILTLL 1151

  Fly  1091 GACNSLLVFPILLSMVGPEAELVPLEHPDRISTPSPLPV--------------------RSSKRS 1135
            |..|.|::.|:|||::||.||:||..:.:.:.:|||.|:                    ..|:.|
Zfish  1152 GILNGLVLLPVLLSLMGPPAEVVPANNANHLQSPSPEPMPPPMNHHGYYAGHIPKASHQAFSETS 1216

  Fly  1136 GKSYVVQGSRSSR-GS-----CQKSHH--------------HHHKDLNDPSLT------------ 1168
            ...|..:.:.:|. |.     |.:|.:              ...|:.:.|.||
Zfish  1217 DSEYYSETTTTSGIGEEEYKYCDRSTYITPPAQPPTTHILLEASKNPSFPKLTVVKPFHEVQNCE 1281

  Fly  1169 -------TITEEPQSWKSSNSS-----IQMPNDWTYQPREQRPASYAAPPPAYHKAAAQQHHQHQ 1221
                   :|:.:.:.|.:.|..     ..:|.|.|   ..||..:...|.|  .:...||.::
Zfish  1282 TKQNAVNSISSQIKRWDNKNEDQGQRRQHLPTDRT---NCQRRTTQCGPGP--QQGTGQQQNR-- 1339

  Fly  1222 GPPTTPPPPFPTAYPPELQSIVVQPEVTVETTHSDSNTTKVTATANIKVEL--AMPG 1276
                      .||:...||             |.::..|.|||||::.|.:  ::||
Zfish  1340 ----------TTAHTGALQ-------------HPNNAITMVTATASVTVAVHPSLPG 1373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	442/1222 (36%)
		MMPL	454..598	CDD:304422	72/147 (49%)
ptch2	NP_571063.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		5/21 (24%)
		2A060602	31..1182	CDD:273338	437/1173 (37%)
		Sterol-sensing	445..595	CDD:289145	73/149 (49%)
		SLC5-6-like_sbd	<1004..>1151	CDD:294310	59/150 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589954
Domainoid	1	1.000	284	1.000	Domainoid score	I1595
eggNOG	1	0.900	-	-		E1_KOG1935
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	841	1.000	Inparanoid score	I425
OMA	1	1.010	-	-		QHG49297
OrthoDB	1	1.010	-	-		D1190129at2759
OrthoFinder	1	1.000	-	-		FOG0003078
OrthoInspector	1	1.000	-	-		otm25600
orthoMCL	1	0.900	-	-		OOG6_105508
Panther	1	1.100	-	-	O	PTHR46022
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2737
SonicParanoid	1	1.000	-	-		X2446
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.390