Protein Alignment ptc and Ptchd4

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: XP_017452249.1
• Gene: Ptchd4 / 301271
• RGDID: 1563020
• Length: 904
• Species: Rattus norvegicus
• Alignment Length: 1168
• Identity: 220/1168 - (18%)
• Similarity: 387/1168 - (33%)
• Gaps: 386/1168 - (33%)

  Fly    55 LRSVFQSHLETLGSSVQKHAGKVLFVAILVLSTFCVGLKSA---QIHSKVHQLWIQEGGRLEAEL 116
            ||...||....||..|.:|  .|.|:.:..:.|...||.:.   |..|.:.:|........:.|.
  Rat    23 LRRGLQSFCHRLGLCVSRH--PVFFLTVPAVLTITFGLSALNRFQTESDLERLVAPSHSLAKIER 85

  Fly   117 AYTQKTIGEDESATHQLLIQTTHDP----NASVLHPQALLAHLEVLVKATAVKVHLYDTEWGLRD 177
            :........|:|.:.  |....|.|    ...:|.|..    ..:|::|
  Rat    86 SLASSLFPLDQSKSQ--LYSDLHTPGRYGRVILLSPPG----DNILLQA---------------- 128

  Fly   178 MCNMPSTPSFEGIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQRLLWTTLNPA 242
                      |||                            |....||:...:|.:....|.:..
  Rat   129 ----------EGI----------------------------LQTHRAVMEMKVNHKGYNYTFSHL 155

  Fly   243 SVMQYMKQKMSEEKISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNKNSTQPPDVGA 307
            .|::...:|.    :..|..:|.:.:::||:.:....:..:...|....|   .:||.....:|.
  Rat   156 CVLRNQDKKC----VLDDIISVLEDLRQAAVSNKTTARVQVRYPNTKLKD---GRNSFIGHQLGG 213

  Fly   308 ILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLG 372
            ::.                  |..:|..|   ::.|:|:|....|.|               :..
  Rat   214 VVE------------------VPNSKDQR---VKSARAIQITYYLQT---------------YGS 242

  Fly   373 WTQEKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDILAKFS-----HPSAL-- 430
            .||:...|   .|:..|.    ||:||..  ..:.|:.::|       ||.||     |.:::
  Rat   243 ATQDLIGE---KWENEFC----QLMRKLQ--DEHQDLQLYS-------LASFSLWRDFHKTSILT 291

  Fly   431 -SIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGL---------SALLGIV 485
             |.|:...|.:|.........:|.:|.:..:|:.|||.:|.|.|...|:         |.||||
  Rat   292 RSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIATAAGIFFITDGKYNSTLLGI- 355

  Fly   486 FNAASTQVVPFLALGLGVDHIFMLTAAYAESNRREQTKLILK-KVGPS---ILFSACSTAGSFF- 545
                     ||.|:|.|...:|.|.:.:    ||.:..|..| :|..:   ::.:...|:..:|
  Rat   356 ---------PFFAMGHGTKGVFELLSGW----RRTKENLPFKDRVADAYSDVMVTYTMTSSLYFI 407

  Fly   546 -----AAAFIPVPALKVFCLQAAIVMCSN------LAAALLVFPAMISLDLRRRTAGRAD----- 594
                 |:.|..:.|:|:||....:.:..|      ...:.|||            ||:.:
  Rat   408 TFGMGASPFTNIEAVKIFCQNMCVSILLNYFYIFSFFGSCLVF------------AGQLEQNRYH 460

  Fly   595 -IFCCCF---------PVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRAD 649
             ||||..         |||.:        ..:::.:.:.:.|..:        |.|:..::.
  Rat   461 SIFCCKIPSAEYLDRKPVWFQ--------TVMSDGHQQTSHHETN--------PYQHHFIQH--- 506

  Fly   650 IPGSSHSLASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKD 714
                           |..:||..::...:||...|:.:|.....|.....::.||..||:|:..|
  Rat   507 ---------------FLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGASIINLLASD 556

  Fly   715 SNEHKFLDAQTRLFGFYSMYAVTQGNFEY--------PTQQQLLR-----------DYHDSFVRV 760
            |....:...|.:   ::|.|:...|.:.|        ..|:.|.|           :.:..|::.
  Rat   557 SPSVSYAMVQQK---YFSNYSPVIGFYVYEPLEYWNSSVQEDLQRLCSGFTAVSWVEQYYQFLKA 618

  Fly   761 PHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHV 825
            .::..|:.   .||..:|.|.:|                 |:..|.:..:|.|.:     :.|..
  Rat   619 SNISANNK---TDFISVLQSSFL-----------------KKPEFQHFRNDIIFS-----RAGDE 658

  Fly   826 DNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYDLK 890
            :|.:...|.|..|....    .|:.....|.               ||.|             |.
  Rat   659 NNIIASRLYLVARTSRD----KQKEVIEVLD---------------KLRP-------------LS 691

  Fly   891 IPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSS 955
            :.||:..:.....|.   .||.:.:...:      .|...|||
  Rat   692 LSKSIRFIVFNPSFV---FTDHNSLSVTV------PVLIAGFG---------------------- 725

  Fly   956 LAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGM 1020
                    :|..|||...|::.......:||||.:....:.|.|||..:.:..|..:.||.::..
  Rat   726 --------VLLVLVLTFFLVIHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNF 782

  Fly  1021 ML--CFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHG-MLTSGVAVFMLSTSPFEFVIRHFCW 1082
            .:  |..:|.:....|. ..|.:.::.|:|      .|| .:...:..|::...|..||..:..:
  Rat   783 AIDHCAPLLYTFVLATE-HTRTQCIKSSLQ------EHGTAILQNITSFLIGLVPLLFVPSNLTF 840

  Fly  1083 LLL-VVLCVGACNSL---LVFPILLSMVGP-----------------EAELVPL-EHPDRIST 1123
            .|. .:|..|.|..|   ::.|:.|:...|                 |.|.:.: |:||.::|
  Rat   841 TLFKCLLLTGGCTLLHCFVILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENPDHVTT 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	220/1168 (19%)
		MMPL	454..598	CDD:304422	42/174 (24%)
Ptchd4	XP_017452249.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348805
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840