Protein Alignment ptc and Disp1

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: XP_038946501.1
• Gene: Disp1 / 289338
• RGDID: 1307675
• Length: 1556
• Species: Rattus norvegicus
• Alignment Length: 1336
• Identity: 244/1336 - (18%)
• Similarity: 435/1336 - (32%)
• Gaps: 446/1336 - (33%)

  Fly   170 DTEWGL---RDMCNMP-----STPSFEGIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVV 226
            :|.|.|   :.||::.     |.|.|..:            |...|.:.|
  Rat   343 ETLWNLPAIKSMCDVDNSRIRSHPQFSDL------------CQRTTAVSC--------------- 380

  Fly   227 IPGLNQRLLWTTLNPASVMQYMK--QKMSEEKISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPN 289
            .|.      ||..|..:::....  ||:.|..:|...:.:....|....|:          |.|:
  Rat   381 CPS------WTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGT----------LGPD 429

  Fly   290 CPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMT 354
            |.|.|..:.                          ::|......|.    ..|..|:..::..:.
  Rat   430 CWDKAARRK--------------------------DQLKCTNVPRK----CTKYNAVYQILHYLV 464

  Fly   355 EKEMYDQWQDNYKVHHLGWTQ-----EKAAEVLNAWQRNFSREVEQLLRKQSRI--ATNYDIYVF 412
            :|:.......:|.|..|.::.     ||...::|.:..||..     ......|  .|..:..:.
  Rat   465 DKDFMTSKTADYAVPALKYSMLFSPTEKGESMMNIYLDNFEN-----WNSSDGITTVTGIEFGIK 524

  Fly   413 SSAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLG 477
            .|...|.:|....:| |::|.|.:.:..:|.              .||.:  .|:..|:..:.|.
  Rat   525 HSLFQDYLLMDTVYP-AIAIAIVLLIMCVYT--------------KSVFI--TLMTMFAIISSLI 572

  Fly   478 LSALL-GIVFNAASTQVVPFLAL-------GLGVDHIFMLTAA--YAESNR-----REQTKLILK 527
            :|..| .:|||   .:..||:.|       |:|.|..|:|...  |.:|::     .|...:.|:
  Rat   573 VSYFLYRVVFN---FEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKSDKPRAETSEAVSVTLQ 634

  Fly   528 KVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLRRRTAGR 592
            ....|:..::.:||.:|:|.....:.|::.|.:.|...:..|....:...||:|.|..|.    .
  Rat   635 HAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERY----L 695

  Fly   593 ADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRADIPGSSHSL 657
            .:||.|   ..|.||:               |.| |||..          :|.::    |.....
  Rat   696 LNIFTC---FRKPQPQ---------------AYH-KSCWT----------VLCRK----GRKALF 727

  Fly   658 ASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPK------DSN 716
            |....:...|:...|.::..: ::|.::.|||..:...|          |:.:.||      :.:
  Rat   728 AISEASRIFFEKVLPCIVIKF-RYLWLVWFLALTVGGAY----------IVCINPKMKLPSLELS 781

  Fly   717 EHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHV----IKNDNGGLP----- 772
            |.:.         |.|.:...:.:.|:.......|.:|...:.:|..    :..::.|.|
  Rat   782 EFQV---------FRSSHPFERYDAEFKKLFMFERVHHGEELHMPITVIWGVSPEDSGDPLNPKS 837

  Fly   773 -----------------DFWLLLFSEWLGNLQKIFDEEYRDGRL----TKECWFPNASSDAILAY 816
                             ..|:|.|.:.|.|.......|.:|...    |.:.|..|...|....|
  Rat   838 KGELTLDSTFNIASPASQAWILHFCQKLRNQTFFHQTEQQDFTSCFIETFKQWMENQDCDEPALY 902

  Fly   817 KLIVQTGHVDNPVDK---ELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPR 878
            ..   ..|...|..:   ||.:...::..|.                    :.|.......|.||
  Rat   903 PC---CSHCSFPYKQEVFELCIKKAIMELDR--------------------STGYHLNNKTPGPR 944

  Fly   879 QYFHQPNEYD---------LKIPKS--LPLVYAQM-PFYLHGLTDTSQIKTLIGHIRDLSVKYEG 931
                    :|         |:...:  ..|.|.:| .||       .::.:.|.|  :||...||
  Rat   945 --------FDINDTIRAVVLEFQSTFLFTLAYEKMQQFY-------KEVDSWISH--ELSSAPEG 992

  Fly   932 FGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSL--LLLSVWAAVLVILSVLASLAQ 994
            .....:.|.:.|...:..::..:.:||.|:..:..:::|::.  :::|::|    |.|:..::..
  Rat   993 LSHGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYA----IASIAGTIFV 1053

  Fly   995 IFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGF-MTSVGNRQRRVQLSMQMSLGPLVHGM 1058
            ..|::.|||.:|:.:.:|.:.::||:.:.|.|...:.: :....:|:.:|..|:         |.
  Rat  1054 TVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSL---------GR 1109

  Fly  1059 LTSGVAVFMLSTSPFEFV---------IRHFCWL---LLVVLCVGACNSLLVFPILLSMVGPEAE 1111
            :.|.:||..|:|    ||         :..:..|   :::|:||....:...|..|...:||:..
  Rat  1110 MGSAIAVAALTT----FVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFFFQCLCRCLGPQGT 1170

  Fly  1112 LVPLEHPDRISTPSPLPVRSSKRSGKS-----------------------YVVQ--GSRSSRGS- 1150
            ...:..|.::...:.....:::..|::                       |.:|  ||.|...|
  Rat  1171 CGQIPLPKKLQCSAFSHTSAARPGGRAPGKATNAYSVDARGQKSELEHELYELQPLGSHSCTSSD 1235

  Fly  1151 ---------CQKSHHHHHKDLNDPS----LTTITEEPQSWKSS-----------------NSSIQ 1185
                     |.:..:...|:|..|.    .:.:|:.|:|...|                 |....
  Rat  1236 MTAYEGPCICSEFFNGQAKNLRMPMSAAYSSELTKSPRSEPGSALLQPCLEQDTMCHFSLNPRCN 1300

  Fly  1186 MPNDWTYQ----PR---EQRPASY-----------------AAPPPAYHKAA------------- 1213
            .||.:|::    |.   :|...|.                 |||..|.|.||
  Rat  1301 CPNAYTHRKYGLPEIHCQQMGDSLCHKCASTAGSFVQIQNAAAPLKATHHAAEGLLHPVQHMLPP 1365

  Fly  1214 -------------AQQHHQHQ---GPPTT---------------PPPPFPTAYPPELQSIVVQPE 1247
                         ..||.|.|   ||.:|               |||...:......|.....||
  Rat  1366 GMQNSQSRNFFLHPVQHFQAQESLGPTSTRGRENTDERPPRTAEPPPAGASRSSESFQRACCNPE 1430

  Fly  1248 ----------VTVETTHSDSNTTKVTATAN--IKVE 1271
                      .:.:|..|....|||...||  .|||
  Rat  1431 NNQRRLCKSRDSGDTEGSGGTETKVCGLANQTDKVE 1466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	192/1061 (18%)
		MMPL	454..598	CDD:304422	38/158 (24%)
Disp1	XP_038946501.1	Patched	467..1147	CDD:355433	153/818 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348807
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840