Protein Alignment ptc and ptr-1

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: NP_505380.1
• Gene: ptr-1 / 191746
• WormBaseID: WBGene00004216
• Length: 956
• Species: Caenorhabditis elegans
• Alignment Length: 1172
• Identity: 216/1172 - (18%)
• Similarity: 406/1172 - (34%)
• Gaps: 334/1172 - (28%)

  Fly    30 SWVDAQVALDQIDKGKARGSRTAIYLRSVFQSHLETLGSSVQKHAGKVLFVAILVLSTFCVGLKS 94
            ||.|     |:|.|         ::.|         :|.:|.|.....|.::..:|:....|.
 Worm     2 SWFD-----DKIHK---------VFFR---------VGENVHKFRLYFLLLSFAILTFSAFGF-- 41

  Fly    95 AQIHSKVHQLWIQEGGRLEAELAYTQKTIGEDESATHQLLIQTTHDP-------NASVLHPQALL 152
                     ||..|                           |||:||       ||...:.:|:|
 Worm    42 ---------LWFTE---------------------------QTTNDPQYVFSPANAPWRYERAVL 70

  Fly   153 --------------------AHLEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFEGIYYIEQIL 197
                                .:::|:...   ::|   .::|         .|:...|.|::::.
 Worm    71 TEHWPLDEEKFWPGKSYDLHGYVDVIASG---RIH---PDYG---------RPNILNIRYLDEVA 120

  Fly   198 R--HLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQRLLWTT-LNPASVMQYMKQKMSEEKISF 259
            |  ..|..::..|:|       :.|....:....|..|..|.. ||....|...|.:..
 Worm   121 RINDYIIHNLTVPVD-------INGKHYDIAYTDLCMRYDWACYLNDHITMLMPKTRWG------ 172

  Fly   260 DFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAP-NKNSTQPPDVGAILSGGCYGYAAKHMHW 323
            :|             ||...:...:.:|.....|.| ....|:|...||::
 Worm   173 NF-------------SGPFAELASDIINTQVNITYPIGWRGTEPIYFGALV-------------- 210

  Fly   324 PEELIVGGAKR--NRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNAWQ 386
                   ||..  :..||...|.|::  :...|.:...||       :.:.|.::     |:.|.
 Worm   211 -------GAPNLVDEEGHFDYASAIR--LTYNTREGKVDQ-------YGIEWRRK-----LSMWL 254

  Fly   387 RNFSREVEQLLRKQSRIATNYDIYVFSSA--ALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLR 449
            .:....|.:||    ....|:::.:....  ..|.:..||....|:.......|:|:     |.:
 Worm   255 TDKENPVSELL----EFGVNHNMTLPEGLQDVADTLAPKFVGTCAILFTFSFLVSVV-----LRK 310

  Fly   450 WR------DPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFM 508
            .|      |.||.:..|..||::....:|....||....|.::||. ..|.|||.|.:|:|.:|:
 Worm   311 HRTGQVMPDWVRSKPLVAAAGLMTPIMATVTSFGLILWCGFLYNAI-VNVSPFLILCIGIDDLFI 374

  Fly   509 LTAAYAESNRREQTKLILKKVGP-------SILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVM 566
            :.|.:..:|.:...:   |::|.       :|..::.:...:|....:..:|.:::||:... |.
 Worm   375 MCAEWHRTNPQHSPE---KRIGKTLSEAAVAISITSLTDIATFAMGCYTTLPGVQMFCMYTC-VQ 435

  Fly   567 CSNLAAALLVF--PAM-ISLDLRR--------RTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNN 620
            |.......::|  |.: .:.::.:        |.|...|.......:|.....|        |..
 Worm   436 CFFCYVYQIIFLGPVLAYAAEMEQNGQHVLLIRKAVDPDKTESPVKLWLLSGSV--------NRQ 492

  Fly   621 GRGARHPKSCNNNRVPLPAQNP----------------LLEQRADIPGSSHSLASFSLATFAFQH 669
            .:.||.    .|:|...|.:..                .||:..|.||.:   :..:|.:..|:.
 Worm   493 DQEARR----RNSRKVAPVEKEGEKKSKFGEVVEKLEHTLEKHDDDPGHN---SEETLVSKVFRE 550

  Fly   670 YT-PFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFYSM 733
            .. ||:::...:...::.:|..:..::.....:::|||     ||......|.     |..||.:
 Worm   551 IIGPFILQKSTQVCALLLYLVYISLAIGGCLNIKEGLD-----PKLLVRESFY-----LSKFYEI 605

  Fly   734 YAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGR 798
              :.:..:....|.|:             |:.|.    ||    ||:.   ..:|.|||...:..
 Worm   606 --IDETFWREGLQMQV-------------VVNNP----PD----LFTP---ETRKGFDEMMAEFE 644

  Fly   799 LTKECWFPNASSDAILAYKLIVQTG----HVDNP---VDKELVLTNRLVNSDGIINQRAFYNYLS 856
            .|:....|||:...:.||:..::|.    :::.|   |:......:.|:.:.|    |..:....
 Worm   645 NTQYTMHPNATMIWLRAYEHHLETEVHELNIEKPNSTVEWYTRCRDWLIVAGG----RRLWQMDM 705

  Fly   857 AWA------TNDVFAYGASQG-KLYPEPRQYFHQPNEYDLKIPKSLPLVYAQMPFYLHGLTDTSQ 914
            .||      |..:.|:....| :.|..|..:.|           |..|
 Worm   706 VWANTTFEETPRITAFRFQLGLRNYRTPTDHTH-----------SCKL----------------- 742

  Fly   915 IKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSLLLLSVW 979
                   :|.::.||..|.:..:....||.  :||:.|..||...:...|.....:..:::..:.
 Worm   743 -------MRSIADKYSMFNVTTFHEYYPFA--DQYLELTPSLFQNMISDLCTIFAVSWVMIPELI 798

  Fly   980 AAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGNRQRRVQ 1044
            .||.::||:.:....:.|.|:..|:.|.::..:.:|:.:|..:..:..|:..|..|.||...|..
 Worm   799 CAVAIVLSIASINVGVLGFMSFWGVNLDSVSIITVIMCIGFSVDLSAHIAYAFSQSYGNSHARAV 863

  Fly  1045 LSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGPE 1109
            .:::....|:..| .:|.|...:|.|....::::.|...:.:|:.....:.|:..||.|..|..|
 Worm   864 AALETLGWPVFLG-ASSTVLGILLLTLVDSYIVQIFFKTVFLVINFSILHGLIFLPIFLMKVVRE 927

  Fly  1110 AE 1111
            .:
 Worm   928 VK 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	216/1172 (18%)
		MMPL	454..598	CDD:304422	35/161 (22%)
ptr-1	NP_505380.1	Patched	47..926	CDD:308203	199/1061 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4544
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860