DRSC/TRiP Functional Genomics Resources

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Protein Alignment ptc and ptc-3

DIOPT Version :9

Sequence 1:NP_523661.2 Gene:ptc / 35851 FlyBaseID:FBgn0003892 Length:1286 Species:Drosophila melanogaster
Sequence 2:NP_001122650.1 Gene:ptc-3 / 173631 WormBaseID:WBGene00004210 Length:1367 Species:Caenorhabditis elegans


Alignment Length:1400 Identity:389/1400 - (27%)
Similarity:642/1400 - (45%) Gaps:315/1400 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 THGDVVDEKL--------FSDLYIR-----TSWVDAQVALDQIDKGKARGSRTAIYLRSVFQSHL 63
            ||...::.:|        |||.:.:     .:|.||.::|.||.:|||.|:..|:..|:.||..|
 Worm    25 THRKFLENRLIGNFDSEDFSDAWKKKFAHAPTWCDADMSLQQIKRGKAVGNTVALTARAFFQLWL 89

  Fly    64 ETLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIHSKVHQLWIQEGGRLEAELAYTQKTIGEDES 128
            ..:|..||:.|...:|:::.:......||:...|.:.:.:||:.|||||..|:.|..:...|.||
 Worm    90 FRIGCFVQRWAWSTIFISLFLYCLCLGGLRHVTIETDLVKLWVSEGGRLNEEMGYLGQVKFERES 154

  Fly   129 A--TH-------------------------------------QLLIQTTHDPNASVLHPQALLAH 154
            .  .|                                     |::|||......::|..:||..|
 Worm   155 GHLVHKVKRAVEQTTEPPAPAVKAEVRRGPELPKENGLGGGFQVVIQTPSFDGQNILSKEALQQH 219

  Fly   155 LEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFE-----GIYYIEQILRHLIPCSIITPLDCFWE 214
            .:::.:.:..:|.:::..|.|.|:|..|..|||.     ||  :.::|..:|||..|||:||:|:
 Worm   220 TKLMEEISTYEVKMFNETWTLSDICFKPPGPSFNSGPLAGI--MSKLLDKIIPCIWITPIDCYWD 282

  Fly   215 GSQLLGPESAVVIPGLN--------------QRLLWTTLNPASVMQYMKQKMSEEKISFDFETVE 265
            |::.|||.     |.||              ..:.|..|||.||::       |....||...:.
 Worm   283 GAKPLGPN-----PPLNLGPEVASFVSSLPPGNVTWKNLNPTSVIK-------EVGTLFDLGPIG 335

  Fly   266 QYMKRAAIGSGYMEKPCLNPLNPNCPDTAPN---------------------------------- 296
            .:.:||.|...|:::||::||...||.:|||                                  
 Worm   336 NFFERAGIDGAYLDRPCIDPLEEECPKSAPNYFDRCHALTKFNEWNMAKAMSEQVTLERKIIPKD 400

  Fly   297 ----------------------------------------------------KNST--------- 300
                                                                .|||         
 Worm   401 DGKSDIAETILNDIFGKKRRKRQADTTTKKPATKKDEDYYEYEDDADYLAGIANSTIAKKNPEKE 465

  Fly   301 --------------------------------QP--PDVGAILSGGCYGYAAKHMHWPEELIVGG 331
                                            .|  |:.|.:::|||.|:..|.|.|||:||:||
 Worm   466 AKDLLCLEYGSSLLKWMQENPERLGEFLTKEEMPDYPNYGDVMTGGCKGFGKKIMEWPEDLIIGG 530

  Fly   332 AKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLG--------WTQEKAAEVLNAWQRN 388
            .:|: :|.|..|:|||||..:....:::.:.:::....|.|        |   .|.|:::.||||
 Worm   531 IQRD-NGKLVSAEALQSVFLVSGAYDVFARIKNDKTDSHPGLDRHHFQPW---MAGEIISTWQRN 591

  Fly   389 FSREV-EQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLR--- 449
            |::.: ...|.::.|     ..:..:|.::.|:|.:||..:.:.||||..:.|:||..|..|   
 Worm   592 FTKRLYSHELNRERR-----QFHPLASTSIADMLEEFSQFNYIIIVIGYILMVIYAAFTQGRFQG 651

  Fly   450 WRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYA 514
            |...|:...::.:.||:|:..|:..|||.:..|||.||||:|||||||:||||:|.:|:|...|.
 Worm   652 WWLAVQSNVALAICGVILVTISSICGLGFATHLGINFNAATTQVVPFLSLGLGIDDMFLLLHNYD 716

  Fly   515 E----SNRREQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALL 575
            |    .|:.| ..::||:.|.|::.::.:...:|.:...:|:|||:.||.|.||::..||...:.
 Worm   717 EIINICNKNE-IGVLLKETGMSVMLTSINNILAFISGYVLPIPALRSFCSQTAILLAFNLIFLMF 780

  Fly   576 VFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQ 640
            :|||||.:||||:..|:.|:..|                      .||  :|:...:..||....
 Worm   781 IFPAMIGIDLRRQRKGKRDLAYC----------------------SRG--NPQMATSQSVPSNVS 821

  Fly   641 NPLLEQRADIPGSSHSLAS-------FSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYAS 698
            |  :..||::.|.......       :::..|..:.|.|.|..:.||...::|...|::..||..
 Worm   822 N--MSSRAELAGYEKQADEYKRHEPWYTVGGFLNKIYIPALKNNVVKACVLIGTTTAVVFGLYGM 884

  Fly   699 TRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFYSMYAVTQGN-FEYPTQQQLLRDYHDSFVRVPH 762
            .....||::.|::|:.:....||.|:.:.|.||.|:||.:|: .:.|.||||:.:|.........
 Worm   885 YTSTLGLELADVLPEHTPPAAFLRAREQYFSFYPMFAVLRGDKLDIPNQQQLIEEYRAQLGSSKF 949

  Fly   763 VIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFP------NASSDAILAYKLIVQ 821
            :||.: |.|..:|:.:...||.:|....:::...|:.......|      ..|.::::|.:|:..
 Worm   950 MIKAE-GKLQPYWMSMLRVWLQSLDMALEKDLAAGKFDLTNGNPIKVNGEKPSPESMIAARLVCS 1013

  Fly   822 TG---HVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQ 883
            .|   :.|..:.|..::.|.::|.:|      |||||:.|...|...|..||...||.|..:   
 Worm  1014 FGTNYNCDGRLGKMKMVENEVINPEG------FYNYLTGWFNVDNMMYYVSQASFYPTPPGW--- 1069

  Fly   884 PNEYDLK----IPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFI 944
              ||:.|    :|.:.||:|:|||||.:.|.||..|..:|..||....:|...||.|:||||.|.
 Worm  1070 --EYNEKLAKVVPAAEPLLYSQMPFYQNDLIDTPAIVKMIEEIRATCEEYSERGLSNHPSGIAFT 1132

  Fly   945 FWEQYMTLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAI 1009
            |||||:|||.:|...:..:.||...::|:|:.:.|||.|::..|:.:..::.|.|.|:|||::.|
 Worm  1133 FWEQYLTLRWNLFQAICIIALAVFCVISILMFNPWAATLIMCIVVITTIELGGFMGLMGIKMNPI 1197

  Fly  1010 PAVILILSVGMMLCFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFE 1074
            .||.||.:||:.:.|...:.|.|:|::|...:|::..:|....|:.||.:::.:.|.||..|.|:
 Worm  1198 SAVTLICAVGIGVEFTAHVELAFLTALGTIDQRLESCLQHMFVPVYHGAISTFLGVVMLVFSEFD 1262

  Fly  1075 FVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGPEAELVPLEHPDRISTPSPLPVRSSKRSGKSY 1139
            ||:.:|.:.:.:::.:|..|.|.|.|::|::|||:.||.|.:....:..|.||..:.:::||.  
 Worm  1263 FVVTYFFYTMTLLVALGVFNGLCVLPVILTLVGPKPELTPTDGSSVLPPPPPLRQQYAEKSGG-- 1325

  Fly  1140 VVQG-------------SRSSRGSCQKSHHHHHKD 1161
             |:|             ..|:|.|...|...|..|
 Worm  1326 -VEGGMRKRKEKRPAEVEMSARDSPSTSSASHSSD 1359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ptcNP_523661.2 2A060602 17..1134 CDD:273338 377/1353 (28%)
MMPL 454..598 CDD:304422 60/147 (41%)
ptc-3NP_001122650.1 2A060602 55..1307 CDD:273338 370/1313 (28%)
MMPL 656..805 CDD:304422 61/171 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 217 1.000 Domainoid score I1542
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H223
Inparanoid 1 1.050 636 1.000 Inparanoid score I456
Isobase 1 0.950 - 0 Normalized mean entropy S4544
OMA 1 1.010 - - QHG49297
OrthoDB 1 1.010 - - D1190129at2759
OrthoFinder 1 1.000 - - FOG0003078
OrthoInspector 1 1.000 - - otm14252
orthoMCL 1 0.900 - - OOG6_105508
Panther 1 1.100 - - LDO PTHR46022
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2737
SonicParanoid 1 1.000 - - X2446
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.960

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