Protein Alignment ptc and ptc-3

DIOPT Version :10

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: NP_001122650.1
• Gene: ptc-3 / 173631
• WormBaseID: WBGene00004210
• Length: 1367
• Species: Caenorhabditis elegans
• Alignment Length: 1400
• Identity: 389/1400 - (27%)
• Similarity: 642/1400 - (45%)
• Gaps: 315/1400 - (22%)

  Fly    12 THGDVVDEKL--------FSDLYIR-----TSWVDAQVALDQIDKGKARGSRTAIYLRSVFQSHL 63
            ||...::.:|        |||.:.:     .:|.||.::|.||.:|||.|:..|:..|:.||..|
 Worm    25 THRKFLENRLIGNFDSEDFSDAWKKKFAHAPTWCDADMSLQQIKRGKAVGNTVALTARAFFQLWL 89

  Fly    64 ETLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIHSKVHQLWIQEGGRLEAELAYTQKTIGEDES 128
            ..:|..||:.|...:|:::.:......||:...|.:.:.:||:.|||||..|:.|..:...|.||
 Worm    90 FRIGCFVQRWAWSTIFISLFLYCLCLGGLRHVTIETDLVKLWVSEGGRLNEEMGYLGQVKFERES 154

  Fly   129 A--TH-------------------------------------QLLIQTTHDPNASVLHPQALLAH 154
            .  .|                                     |::|||......::|..:||..|
 Worm   155 GHLVHKVKRAVEQTTEPPAPAVKAEVRRGPELPKENGLGGGFQVVIQTPSFDGQNILSKEALQQH 219

  Fly   155 LEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFE-----GIYYIEQILRHLIPCSIITPLDCFWE 214
            .:::.:.:..:|.:::..|.|.|:|..|..|||.     ||  :.::|..:|||..|||:||:|:
 Worm   220 TKLMEEISTYEVKMFNETWTLSDICFKPPGPSFNSGPLAGI--MSKLLDKIIPCIWITPIDCYWD 282

  Fly   215 GSQLLGPESAVVIPGLN--------------QRLLWTTLNPASVMQYMKQKMSEEKISFDFETVE 265
            |::.|||.     |.||              ..:.|..|||.||::       |....||...:.
 Worm   283 GAKPLGPN-----PPLNLGPEVASFVSSLPPGNVTWKNLNPTSVIK-------EVGTLFDLGPIG 335

  Fly   266 QYMKRAAIGSGYMEKPCLNPLNPNCPDTAPN---------------------------------- 296
            .:.:||.|...|:::||::||...||.:|||
 Worm   336 NFFERAGIDGAYLDRPCIDPLEEECPKSAPNYFDRCHALTKFNEWNMAKAMSEQVTLERKIIPKD 400

  Fly   297 ----------------------------------------------------KNST--------- 300
                                                                .|||
 Worm   401 DGKSDIAETILNDIFGKKRRKRQADTTTKKPATKKDEDYYEYEDDADYLAGIANSTIAKKNPEKE 465

  Fly   301 --------------------------------QP--PDVGAILSGGCYGYAAKHMHWPEELIVGG 331
                                            .|  |:.|.:::|||.|:..|.|.|||:||:||
 Worm   466 AKDLLCLEYGSSLLKWMQENPERLGEFLTKEEMPDYPNYGDVMTGGCKGFGKKIMEWPEDLIIGG 530

  Fly   332 AKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLG--------WTQEKAAEVLNAWQRN 388
            .:|: :|.|..|:|||||..:....:::.:.:::....|.|        |   .|.|:::.||||
 Worm   531 IQRD-NGKLVSAEALQSVFLVSGAYDVFARIKNDKTDSHPGLDRHHFQPW---MAGEIISTWQRN 591

  Fly   389 FSREV-EQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLR--- 449
            |::.: ...|.::.|     ..:..:|.::.|:|.:||..:.:.||||..:.|:||..|..|
 Worm   592 FTKRLYSHELNRERR-----QFHPLASTSIADMLEEFSQFNYIIIVIGYILMVIYAAFTQGRFQG 651

  Fly   450 WRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYA 514
            |...|:...::.:.||:|:..|:..|||.:..|||.||||:|||||||:||||:|.:|:|...|.
 Worm   652 WWLAVQSNVALAICGVILVTISSICGLGFATHLGINFNAATTQVVPFLSLGLGIDDMFLLLHNYD 716

  Fly   515 E----SNRREQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALL 575
            |    .|:.| ..::||:.|.|::.::.:...:|.:...:|:|||:.||.|.||::..||...:.
 Worm   717 EIINICNKNE-IGVLLKETGMSVMLTSINNILAFISGYVLPIPALRSFCSQTAILLAFNLIFLMF 780

  Fly   576 VFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQ 640
            :|||||.:||||:..|:.|:..|                      .||  :|:...:..||....
 Worm   781 IFPAMIGIDLRRQRKGKRDLAYC----------------------SRG--NPQMATSQSVPSNVS 821

  Fly   641 NPLLEQRADIPGSSHSLAS-------FSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYAS 698
            |  :..||::.|.......       :::..|..:.|.|.|..:.||...::|...|::..||..
 Worm   822 N--MSSRAELAGYEKQADEYKRHEPWYTVGGFLNKIYIPALKNNVVKACVLIGTTTAVVFGLYGM 884

  Fly   699 TRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFYSMYAVTQGN-FEYPTQQQLLRDYHDSFVRVPH 762
            .....||::.|::|:.:....||.|:.:.|.||.|:||.:|: .:.|.||||:.:|.........
 Worm   885 YTSTLGLELADVLPEHTPPAAFLRAREQYFSFYPMFAVLRGDKLDIPNQQQLIEEYRAQLGSSKF 949

  Fly   763 VIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFP------NASSDAILAYKLIVQ 821
            :||.: |.|..:|:.:...||.:|....:::...|:.......|      ..|.::::|.:|:..
 Worm   950 MIKAE-GKLQPYWMSMLRVWLQSLDMALEKDLAAGKFDLTNGNPIKVNGEKPSPESMIAARLVCS 1013

  Fly   822 TG---HVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQ 883
            .|   :.|..:.|..::.|.::|.:|      |||||:.|...|...|..||...||.|..:
 Worm  1014 FGTNYNCDGRLGKMKMVENEVINPEG------FYNYLTGWFNVDNMMYYVSQASFYPTPPGW--- 1069

  Fly   884 PNEYDLK----IPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFI 944
              ||:.|    :|.:.||:|:|||||.:.|.||..|..:|..||....:|...||.|:||||.|.
 Worm  1070 --EYNEKLAKVVPAAEPLLYSQMPFYQNDLIDTPAIVKMIEEIRATCEEYSERGLSNHPSGIAFT 1132

  Fly   945 FWEQYMTLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAI 1009
            |||||:|||.:|...:..:.||...::|:|:.:.|||.|::..|:.:..::.|.|.|:|||::.|
 Worm  1133 FWEQYLTLRWNLFQAICIIALAVFCVISILMFNPWAATLIMCIVVITTIELGGFMGLMGIKMNPI 1197

  Fly  1010 PAVILILSVGMMLCFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFE 1074
            .||.||.:||:.:.|...:.|.|:|::|...:|::..:|....|:.||.:::.:.|.||..|.|:
 Worm  1198 SAVTLICAVGIGVEFTAHVELAFLTALGTIDQRLESCLQHMFVPVYHGAISTFLGVVMLVFSEFD 1262

  Fly  1075 FVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGPEAELVPLEHPDRISTPSPLPVRSSKRSGKSY 1139
            ||:.:|.:.:.:::.:|..|.|.|.|::|::|||:.||.|.:....:..|.||..:.:::||.
 Worm  1263 FVVTYFFYTMTLLVALGVFNGLCVLPVILTLVGPKPELTPTDGSSVLPPPPPLRQQYAEKSGG-- 1325

  Fly  1140 VVQG-------------SRSSRGSCQKSHHHHHKD 1161
             |:|             ..|:|.|...|...|..|
 Worm  1326 -VEGGMRKRKEKRPAEVEMSARDSPSTSSASHSSD 1359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	377/1353 (28%)
ptc-3	NP_001122650.1	2A060602	55..1307	CDD:273338	370/1313 (28%)