Protein Alignment ptc and ptr-11

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: NP_490687.1
• Gene: ptr-11 / 171609
• WormBaseID: WBGene00004225
• Length: 820
• Species: Caenorhabditis elegans
• Alignment Length: 814
• Identity: 166/814 - (20%)
• Similarity: 297/814 - (36%)
• Gaps: 235/814 - (28%)

  Fly   374 TQEKAAEVLNAWQRNFSRE------------VEQL--LRKQSRIATNYDIYVFSSAALDDILAKF 424
            |:..:::.|..|.  |||.            :::|  |.|.|....:....:||....:..:.:.
 Worm   174 TERISSKSLVLWY--FSRSDTPEGKLAFKDAIDELFQLSKNSSAFEHVQFTIFSDQVANREMIRG 236

  Fly   425 SHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVA------GVLLMCFSTAAGLGLSALLG 483
            :..:...:.||..:.:......::|       .|||.:|      .:|....:|.|..|....:|
 Worm   237 AIEATTLMTIGFFLLLTQVIIVIVR-------LSSVKMAFYLVATSLLTPMAATVASFGAICWMG 294

  Fly   484 IVFNAASTQ-VVPFLALGLGVDHIFMLT------AAYAESNRR-EQTKLILKKVGPSILFSACST 540
              |.:.|.| |.|||.||:|||..|:|.      .|..::.|| ||   ::..|||||..::.:.
 Worm   295 --FPSFSIQCVTPFLVLGIGVDDAFILLHRWKHHIAITDTPRRLEQ---VIVDVGPSITITSLTN 354

  Fly   541 AGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALL--VFPAMISLDLRRRTAGRADIFCCCFPVW 603
            ..:|......|.|.:.:|||.|::       |.||  :|...|...:         :|.|..|.:
 Worm   355 IIAFGIGFLTPTPQMSLFCLTASL-------ALLLDYIFTYTILAPI---------VFLCNDPDY 403

  Fly   604 KE-----QPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRADIPGSSHSLASFSLA 663
            |.     :||::                                    |||
 Worm   404 KSIANETEPKIS------------------------------------RAD-------------- 418

  Fly   664 TFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRL- 727
            |: ...|:.|:.....:...:|..|.....:.|....::...:.....|.:|   |.:|:.:.:
 Worm   419 TW-LSKYSSFVCSVKGRVACIMVLLGMYALTTYGVVTMKTTFEPAKAFPSNS---KLVDSLSNIK 479

  Fly   728 --FGFYSMYAVTQGNFEYPTQQQLLRDYHDSF----VRVPHV--IKNDNGG---LPDFWLLLFSE 781
              |..|....|...|   |...::..:| |||    .|:.||  |:.||..   ||.:  :.|.:
 Worm   480 PVFNRYFPITVIVNN---PPNIEIKAEY-DSFNNMMDRLEHVPGIRGDNRSLIFLPQY--VNFDK 538

  Fly   782 WLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHV--DNPVDKELVLTNRLVNSDG 844
            .:..|..:..|:||........|.....:..::.|       |:  ||   |.:|...||.
 Worm   539 TMNILSTLVGEKYRPSYDNLPTWMDAIGNPPLVKY-------HMGDDN---KTIVTAFRLT---- 589

  Fly   845 IINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYDLKIPKSLPLVYAQMPFYLHGL 909
            ::.:.     :|.|         |.:.:.....|...|:.::::..:                 .
 Worm   590 LLGKG-----MSEW---------AERARAMQHIRTILHEESQFNATL-----------------F 623

  Fly   910 TDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSLL 974
            ...|.|.::|     |:|..:..|                     |:|:.:.|     :.:|..:
 Worm   624 DCDSAILSII-----LTVGTDLIG---------------------SIAVTVVC-----MAIVCFV 657

  Fly   975 LLSVWAAVLVILSVLASLAQIF-GAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGN 1038
            .::.:.||.||.||:||:..:. |.::|.|..|..:..|.::|:.|..:.:...::..|..:.|.
 Worm   658 FIANFNAVAVITSVIASICYVLVGGLSLWGADLDPVIQVDVLLATGFSVDYTAHVAYNFFRARGT 722

  Fly  1039 RQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFV----IRHFCWLLLVVLCVGACNSLLVF 1099
            .|.||    ..||..:...|..:|::.| |...|..||    |..|...:.:|:.:|..:.|.:.
 Worm   723 PQERV----YSSLAEMAMPMCEAGLSTF-LCMLPLIFVPTYAIVCFAKTVFLVVAIGLLHGLFIL 782

  Fly  1100 PILLSMVGPEAELVPLEHPDRI------STPSPL 1127
            |::|::...::    :...|.|      |...||
 Worm   783 PVILALFSKDS----INEKDNIPAAITFSAAEPL 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	166/814 (20%)
		MMPL	454..598	CDD:304422	46/159 (29%)
ptr-11	NP_490687.1	Patched	35..791	CDD:355433	161/787 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4544
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860