Protein Alignment ptc and disp3

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: XP_021334179.1
• Gene: disp3 / 100535855
• ZFINID: ZDB-GENE-081104-407
• Length: 1319
• Species: Danio rerio
• Alignment Length: 1267
• Identity: 222/1267 - (17%)
• Similarity: 407/1267 - (32%)
• Gaps: 423/1267 - (33%)

  Fly   107 QEGGRLEAELAYTQK------TIGEDESATHQL----LIQTTHDPNASVLHPQALLAHLEVLVKA 161
            |.|.....|:...:|      |:...::..|:.    |::|........|..|||.
Zfish   171 QFGNEKNKEMKEREKDSSISATLNSSDAEDHKKPDSPLMRTRRFAGYPYLQTQALW--------- 226

  Fly   162 TAVKVHLYDTEWGLRDMCNMPSTPS-FEGIYYIEQIL-RHLIPCSIITPLDCFWEGSQLLGPESA 224
               ::.|.....|.:|  |...||. ...|:::|::| :|                     |:.
Zfish   227 ---RIELVFVAQGDKD--NNIFTPDRLHTIHHVERVLMQH---------------------PQF- 264

  Fly   225 VVIPGLNQRLLWTTLN--------------PASVMQYMKQKMSEEKISFDFETVEQYMKRAAIGS 275
                   |:..|..|.              |:||:.|:.......||.:|             |.
Zfish   265 -------QQFCWKPLEALQDLPLGPSFCSPPSSVLSYLFPSERAGKIYYD-------------GM 309

  Fly   276 GYMEKPCLNPLNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKH--MHW-------PEELIVGG 331
            |              ||.|         |:...||     .|..|  .:|       |::|
Zfish   310 G--------------PDLA---------DIHGALS-----LAITHPQFYWYVDESLTPDKL---- 342

  Fly   332 AKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNAWQRNFSREVEQL 396
                      ::..|:|.:........:...||            :..|....: |:|..:...:
Zfish   343 ----------QSSLLRSEIHFGAPLPSFYSLQD------------RPLEQRRLF-RDFVVQYAGI 384

  Fly   397 LRKQSRIATNYDIYVFSSAAL--DDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSS 459
            |.:||   |:....::....|  |::...|:....|::..|..:|||....|...
Zfish   385 LAQQS---TSKVKVLYGGTELFDDEVRKTFNSDMLLALFSGGCITVLVYVLTSFS---------- 436

  Fly   460 VGVAGVLLMCFSTAAGLGLSALL---------GIVFNAASTQVVPFLALGLGVDHIFMLTAAYAE 515
                  :.:.|...|.:|||.|:         |:.:......|..|:.:|:|||.:|:..:.:.:
Zfish   437 ------VFLTFFGLASIGLSCLVALFLYHVVFGVKYLGILNGVAAFVIIGIGVDDVFVFISTFRQ 495

  Fly   516 S-------NRREQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCL-QAAIVMCSNLAA 572
            |       .|...|   :|..|.:...::.:||.::.|..|..:||:..|.| .:.||.|..|..
Zfish   496 SVHLTCPMQRMIST---MKTAGRATFLTSFTTAAAYAANTFSQIPAVHDFGLFMSLIVSCCWLWV 557

  Fly   573 ALLVFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNN-----------GRGARH 626
            ::|: ||.:.: .....|.||:   .|...|....|::....||::::           |.....
Zfish   558 SVLM-PAALCI-WSSCGAARAN---SCPRWWTTLTKLSSSPGPLSDDDDVALITVEMEPGVYDSE 617

  Fly   627 PKSCNNNRVPLPAQNPLLEQRADIPGSSHSLASFSLATFAFQHYTPFLMRSWV------KFLTVM 685
            |.:.            ||....:.|.|:.:..:..:.:...|.    |:|.||      |..|::
Zfish   618 PDAA------------LLSLSTEAPLSASTEGNVGVVSAHIQR----LLRCWVAEPVVEKRKTII 666

  Fly   686 G-FLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRL----------FGFY-------- 731
            | :...|:.|::....|:.......|..:|:|..:.||.::.|          .|.:
Zfish   667 GVYAVVLLGSVWCCCLLRPASHAPVLFHRDTNLQRLLDMRSNLSAQGISCHMCSGVFMERPHNLH 731

  Fly   732 ---SMYAVTQGNF-EYPTQQQ--------------LLRDY--------------HDSFVRVP--- 761
               ...:.|.||. ..|:.|.              ||..|              :.....||
Zfish   732 STADFTSSTSGNHPTIPSNQSKPASNSSAQTLAGGLLTVYVFKLEMGSAVPLYRYSLSASVPAPW 796

  Fly   762 HVIKNDNGGLPDF---------------------------WLLLFSEWLGNLQKIFD-------- 791
            ......:|.:|.|                           |:|......|:.:.|.:
Zfish   797 QASSAAHGDVPSFQAYSSPHSNFSTRISVCVSHAYHPRPRWMLTLRSCDGSRRWIAEFEFYVASV 861

  Fly   792 EEYRDGRL-----------TKECWFP-----------------NASSDAILAYKLIVQT------ 822
            |:.|..:|           ::.|..|                 .|...|..|...|.:|
Zfish   862 EQQRSRKLYFAQHTISPYPSRVCEGPPGCVFSSGPDGPTQGSFYAPLPAAPAQVKISRTSGFNPC 926

  Fly   823 --GHVDNPVDKELVLTNRLV----NSDGIINQRAFYNYLSAWATN-------DVF---------- 864
              |....|..:.||.|..:|    ...|:...:...|::.....|       |||
Zfish   927 SGGKCGKPAVRPLVDTGAMVFVVFGILGVNRTQRLDNHVIGDLGNVIYDQDFDVFNEIGHLCKLC 991

  Fly   865 -AYGASQGKLYPEPRQYFHQPNEYDLKIPKSLPLVYAQM-----PFYLHGLTDTSQIKTLIGHIR 923
             ...|:...:.|...|.....|    .:...|||::.:.     |..|.|......:....|.:.
Zfish   992 KVISANTNLVKPGGAQCLPSGN----SLTSILPLLHPECHSLPEPNLLPGQLSHGAVGLQGGRVH 1052

  Fly   924 DLSVKYEGF---GLPNYPSGIPFIFWEQYM-----TLRSSLAM---------------------- 958
            .:|:.:|..   |..::.:...|:.||.::     :|.:|.|:
Zfish  1053 WISMAFESTTYKGKSSFQTHADFLQWESFLQKQLASLPASSALRRGFQTCQHWKQIFMEIIGVES 1117

  Fly   959 -ILACVLLAALVLVSLLLLSVWAAVL--VILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGM 1020
             :.:.:|..|:.:.|:.:.:....:|  ::||:|..:..:...|..||.::.|:.|:.|.:.||.
Zfish  1118 ALYSLLLSLAICIASVAVFTAHPLLLLPILLSILGMVCLVVAVMYWLGWEMGAVEAISLSILVGS 1182

  Fly  1021 MLCFNVLISLGFMTSVGNRQRRVQLSMQMSLGPL-----VHGMLTSGVAVFMLSTSPFEFVI--- 1077
            .:.:.:.:..|::.:.......:..|::..:..|     |...:.|.....::||.|..|.:
Zfish  1183 SVDYCLHLVEGYLLAGDTETSGLDPSIKRQIRTLEAANHVGVAIVSSAVTTVISTIPLFFCVIVP 1247

  Fly  1078 -RHFCWLLLVVLCVGACNSLLVFPILLSMVGP 1108
             ..|..::.:...:....:|.|...||:.:||
Zfish  1248 FAKFGQIVAINTAISIAFTLTVTTALLAAMGP 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	222/1267 (18%)
		MMPL	454..598	CDD:304422	37/160 (23%)
disp3	XP_021334179.1	Patched	226..>602	CDD:330476	96/513 (19%)
		COG1033	<1157..>1274	CDD:331188	20/116 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930