Protein Alignment ptc and disp2

DIOPT Version :10

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: XP_002940542.3
• Gene: disp2 / 100497287
• XenbaseID: XB-GENE-994606
• Length: 1457
• Species: Xenopus tropicalis
• Alignment Length: 1074
• Identity: 174/1074 - (16%)
• Similarity: 345/1074 - (32%)
• Gaps: 323/1074 - (30%)

  Fly   277 YMEKPCLNPLNPNCPDTAPNKNSTQPPDVGAILSGGCYG---YAAKHMHW---PEELIVGGAKRN 335
            |....|:.....:...|.....|..|......|:..|.|   ..|||.|.   ||:.|
 Frog   359 YNRSSCMEITQSDISHTLTLLRSCAPDYHRGALTPSCIGPRSERAKHSHCAKVPEKCI------- 416

  Fly   336 RSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWT-----QEKAAEVLNAWQRNFSREVEQ 395
                  ::.|:..::..:.:::.......:|:|..|.::     .:|.:.::|.:..|.
 Frog   417 ------RSSAVYQLLHFLLDRDFLSPQTTDYQVPSLKYSLLFLPAKKGSSMMNIYLDNL------ 469

  Fly   396 LLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIV------IGVAVTVLY----AFCTLLRW 450
               :...:..||.........|...|  |.|...|..|      |.:.:::.:    .|.|.:
 Frog   470 ---ESWDLFDNYTAITGMDLGLKQQL--FQHYLVLDTVYPVLAIIAIFLSIFFYLRSVFITFM-- 527

  Fly   451 RDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGV-------DHIFM 508
                   ..:.|.|.||:.|         .|..::|...   ..||:.|..|:       :|.|:
 Frog   528 -------IMISVIGSLLISF---------FLYKLIFRLT---FFPFVNLIAGILLSSICANHAFV 573

  Fly   509 LTAAYAESNRREQTKLILKKVGPS------ILFSACSTAGSFFAAAFI-PVPALKVFCLQAA--- 563
            ....:..|..:.....:::.|..:      ::..:|.|.|:.|.|.:: .:.:::.|.:...
 Frog   574 FFDLWNLSKIQHSAAGLMQWVSHTMHHFGYLMVVSCFTMGAAFYATYMSSITSVRCFAIYMGSSV 638

  Fly   564 ----IVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGA 624
                |.|.|.|.|.::|:...|:::             |.:                     :..
 Frog   639 LVNMIFMISWLPATIVVYERYIAVN-------------CSY---------------------KSE 669

  Fly   625 RHPKSCNNNRVPLPAQNPLLEQRADIPGSSHSLASFSLATFAFQHYTP-------FLMRSWVKFL 682
            .:..|..:.|:       ||.......|...:|:..|  ...|:...|       ::...|...|
 Frog   670 EYWNSSTHKRL-------LLSFCQKFKGLQSTLSETS--KLLFEKLLPCGVIKFRYIWICWFAAL 725

  Fly   683 TVMG-FLAALISSLYASTRLQDGLDIIDL------------------------------------ 710
            ...| ::|.:...|...:.....|.:..|
 Frog   726 AAGGAYIACMSPKLKLPSSEMSSLQVFRLSHPFERYDAEYCHQFMFDRSEHGEGQHMPITLIWGI 790

  Fly   711 VPKDSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDS--FVRVPHVIKN------D 767
            :|.|:::|....|...|        ||...|       .:|:..|.  .:.:.|.:||      |
 Frog   791 MPLDNSDHLNPKANGTL--------VTDATF-------TIRNAEDQNWLMELCHKVKNQSFYYSD 840

  Fly   768 NGGLPDFWLLL-FSEWLGNLQKIFDEEYRDGRLTKEC---WFPNASSDAILAYKLIVQTGHVDNP 828
            .|..|:...:. |..|:.:.|.    ...|..|...|   .||..|...:...|::|:....|.
 Frog   841 QGKKPNICFMEDFHRWMESRQC----SQTDQNLNLCCNHVTFPYKSDILLHCIKMMVREQGGDG- 900

  Fly   829 VDKELVLTNRLVNSDG-----IINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYD 888
              .|:.......::||     ::..:..|:|    :.|            |.:.:::::..|::
 Frog   901 --TEVYDIGPRFDADGNLTALVLEFQTVYHY----SFN------------YSKTKKFYNTLNQW- 946

  Fly   889 LKIPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGI-------PFIFW 946
                                         |:..:|            |.|||:       ....:
 Frog   947 -----------------------------LMNEMR------------NAPSGLQNGWFTSKLSLY 970

  Fly   947 EQYMTLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLA---SLAQIFGAMTLLGIKLSA 1008
            ....||.:.:.::.:..:..:.|   :|||:.|...|.:.:|.|   |:....|.:.||..:|:.
 Frog   971 NLQHTLNTEIMVVTSFSIAISFV---VLLLTTWNVFLSLFAVAAIGGSVMVTTGLLVLLEWQLNV 1032

  Fly  1009 IPAVILILSVGMMLCFNVLISLGF-MTSVGNRQRRVQLSM-QMSLGPLVHGMLTSGVAVFMLSTS 1071
            |.::::..:||:.:.|.....:.: :....:|..||..|: |||....:.........:.||..:
 Frog  1033 IESLLISAAVGLSVDFTTNYCISYHLCPHQDRLSRVAFSLKQMSCATAMGASTMFSAGIIMLPAT 1097

  Fly  1072 PFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGPEAELVPL---------EHPDRISTPSPL 1127
            ...:  |.....::::.|:....:...|..|....|||.....:         |:|:
 Frog  1098 VLAY--RKLGIFIIMIKCISCGFASFFFQSLCCFFGPEMNCGQIIWPCASAFKEYPN-------- 1152

  Fly  1128 PVRSSKRSGKSYVVQGSRSSRGSCQKSHHHHHKDLNDPSLTTITEEPQSWKSSNSSIQMPNDWTY 1192
               .|:.:| ::|..|:..         |:..:.:.:.:......|.|. .:.|.|....|....
 Frog  1153 ---DSRLNG-TFVCGGTEK---------HNRIRKVQESNTDNEQYELQP-LARNLSDSFDNSTCT 1203

  Fly  1193 QPREQRPASYA----APPPAYHKAAAQQHHQHQG 1222
            ....:||:..:    .....|.|..:||:.:.:|
 Frog  1204 SKLSKRPSMVSEDIQISEYKYPKLGSQQNVESEG 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	158/980 (16%)
disp2	XP_002940542.3	MMPL	<501..1049	CDD:440656	109/694 (16%)