Protein Alignment ptc and ptch2

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: XP_002937129.2
• Gene: ptch2 / 100492958
• XenbaseID: XB-GENE-1033868
• Length: 1423
• Species: Xenopus tropicalis
• Alignment Length: 1411
• Identity: 485/1411 - (34%)
• Similarity: 767/1411 - (54%)
• Gaps: 213/1411 - (15%)

  Fly    23 SDLYIRTSWVDAQVALDQIDKGKARGSRTAIYLRSVFQSHLETLGSSVQKHAGKVLFVAILVLST 87
            |||..|.|:..|..||.||.||||.|.:..::||:.||:.|.:||.|:|:|.|||||:.:||...
 Frog    29 SDLLRRPSYCHAAFALKQIAKGKAVGQKAPLWLRAQFQALLFSLGCSIQRHCGKVLFIGLLVFGA 93

  Fly    88 FCVGLKSAQIHSKVHQLWIQEGGRLEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALL 152
            ..|||:.|.|.:.:.:||::.|.|:..||.||::.:||:...|.|:||||......::|..:|||
 Frog    94 LAVGLRVASIETDIERLWVEAGSRVSHELRYTKEKLGEESVYTSQMLIQTPKREGENILTQEALL 158

  Fly   153 AHLEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFE-GIYYIEQILRHLIPCSIITPLDCFWEGS 216
            .||...:.|:.|:|.:|...|.|..:|.....|..| |:  ||:::..|.||.||||||||||||
 Frog   159 LHLRAALAASKVQVSMYGKSWDLNKICYKSGVPIIENGM--IERMIEKLFPCVIITPLDCFWEGS 221

  Fly   217 QLLGPESAVVIPGLNQRLLWTTLNPASVMQYMKQKMSEEKISFDFETVEQYMKRAAIGSGYMEKP 281
            ||.|  .:..:|| ...:.||.|:|..:|:.:.|..|       .:..::.:.:|.:|..|||:|
 Frog   222 QLQG--GSAYLPG-RADIQWTNLDPIQLMEELGQFTS-------LDGFKEMLDKAEVGQAYMERP 276

  Fly   282 CLNPLNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQAL 346
            ||:|.:.:||:::|||.:.:.||:.:.|..||||::.|.|:|.:|||:||..:...|.|:.|:||
 Frog   277 CLDPTDSDCPESSPNKKTKKNPDIVSTLRRGCYGFSKKFMYWQKELILGGMLKGPDGELKSAEAL 341

  Fly   347 QSVVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYV 411
            |::..||:..::|:.::|:|::|.:.|.:||||.:|.:|||.|..:.:|.:.:.|    :.||:.
 Frog   342 QTMYLLMSPGQLYEHFKDDYEIHDINWNEEKAAAILESWQRKFVEQAQQSIPQNS----SQDIHA 402

  Fly   412 FSSAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGL 476
            ||:..|:||:..||..||:.:..|..:.:.||..|:||| |..:.|.:||:|||||:..|.|:||
 Frog   403 FSTTTLNDIMKSFSDVSAIRVAGGYLLMLAYACVTMLRW-DCSKSQGAVGLAGVLLVALSVASGL 466

  Fly   477 GLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYAESNR----REQTKLILKKVGPSILFSA 537
            ||.:||||.||||:|||:||||||:|||.:|:|..|:.|::.    :|:|...|::.|.|:..::
 Frog   467 GLCSLLGISFNAATTQVLPFLALGIGVDDMFLLAHAFTETSLSTPFKERTGECLRRTGTSVALTS 531

  Fly   538 CSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCCCF-P 601
            .:...:||.||.:|:|||:.|.||||:|:..|.|..||:|||::||||.||...|.||.||.: |
 Frog   532 INNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDQRLDILCCFYSP 596

  Fly   602 VWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVP------------------------------ 636
            ......::.|.  ..::.|.....||.|..|..:.
 Frog   597 CSSRVIQIQPQ--EFSDANDNHTYHPSSYGNPTITTSTQITTTVQAFTQCDPSGHHIVTILPPTS 659

  Fly   637 ---------LPAQNPLLEQRADIPGSSHSLAS------------------FSLATFAFQHYTPFL 674
                     :|..:||..|......|:..|.:                  :||:.||.:.|.|.|
 Frog   660 QISTSPSVIVPTMDPLGSQVFSPSSSTRDLLAQLDESKEKRECVPLPFLKWSLSDFAREKYAPVL 724

  Fly   675 MRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFYSMYAVTQG 739
            :::..|.:.|..|:|.|...||.:|.:.|||.:.|:||:::.|:.|:.||.:.|.||:|:.||:.
 Frog   725 LKAETKGIVVALFMALLGLGLYGTTMVHDGLYLTDIVPRETKEYNFISAQFKYFSFYNMFIVTKD 789

  Fly   740 NFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECW 804
            .|:||..|:.|.|.|::|..|.:|::.:...||..||..|.:||..||..||:::..|.:|::.
 Frog   790 GFDYPKAQESLYDLHEAFGSVKYVVREEGRDLPKMWLHYFQDWLRGLQTAFDKDWELGHITEDS- 853

  Fly   805 FPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGAS 869
            :.|.:.|::||:||::|||:...|.:...:.:.|||:..|:|.|.|||.||:.|.:||...|.||
 Frog   854 YRNGTEDSVLAFKLLIQTGNKKEPFNFNQLTSRRLVDEKGLIPQDAFYIYLTVWVSNDPLGYAAS 918

  Fly   870 QGKLYPEPRQYFHQPNEYD-----LKIPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKY 929
            |...||:|.::.|  :.||     |:||.:.|:.:||.||||:||..||.....|..:|.:..::
 Frog   919 QANFYPQPPEWIH--DRYDTTGENLRIPAAEPIEFAQFPFYLNGLRQTSDFIEAIESVRSVCEEF 981

  Fly   930 EGFGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQ 994
            ...|:.:||||.||:|||||:.||....:.::.||....::.::|||:.|.|.:::..:.....:
 Frog   982 VKQGVQSYPSGYPFLFWEQYIGLRHWFLLAISIVLACTFLVCAILLLNPWTAGIIVFILAMMTVE 1046

  Fly   995 IFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGML 1059
            :||.|.|:||||||||.||||.|||:.:.|.|.::|||:|::|:|.:|..|:::....|::.|.:
 Frog  1047 LFGIMGLIGIKLSAIPVVILIASVGIGVEFTVHVALGFLTAIGDRNQRSVLALEHMFAPVLDGAI 1111

  Fly  1060 TSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGPEAELVPLEHPDRISTP 1124
            ::.:.|.||:.|.|:|::|:|..:|.::..:|..|.|::.|:|||::||.||:.|.::..|:.||
 Frog  1112 STLLGVLMLAGSEFDFILRYFFAVLTILTILGLLNGLVLLPVLLSLIGPPAEVTPADNSSRLPTP 1176

  Fly  1125 SPLPVRSSKRSGKSYVVQGSRSSRGSCQKSHHH----HHKDLNDP-------SLTTIT-----EE 1173
            :|.|:.                     ...:||    :||..:||       |.||.|     ::
 Frog  1177 TPEPLP---------------------PPLNHHAFYMNHKGFSDPEDSSEYYSETTTTSGLEEDD 1220

  Fly  1174 PQSWKSS---------------------------------------------NSSIQMP------ 1187
            ||.::.|                                             |:|..:|
 Frog  1221 PQLYERSAYIIPPKPPHIILEASKDPTYPKIMLVKPCKGNQDVPGKKDSKDINNSEALPGKDISH 1285

  Fly  1188 ------NDWTYQPREQRP-----ASYAAPPPAY--HKAAAQQHHQHQGPPTTPPPPFPTAYPPEL 1239
                  .| |.:||..|.     |:.:.|....  ..:.||...:.||..|.||     ||..::
 Frog  1286 RTCQEQKD-TQEPRGSRMRQHQLATSSGPTRTNQPQNSRAQHSTRPQGHRTAPP-----AYCAKM 1344

  Fly  1240 QSIVVQPEVTVETTHSDSNTTKVTATANIKVEL--AMPGRAVRSYN 1283
            .:             .:.:.|.|||||::.|.:  ::|| .||.||
 Frog  1345 SA-------------PNGSITTVTATASVTVAVHPSLPG-TVRGYN 1376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	440/1178 (37%)
		MMPL	454..598	CDD:304422	73/147 (50%)
ptch2	XP_002937129.2	Patched	26..1172	CDD:355433	435/1164 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I1500
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	850	1.000	Inparanoid score	I431
OMA	1	1.010	-	-		QHG49297
OrthoDB	1	1.010	-	-		D1190129at2759
OrthoFinder	1	1.000	-	-		FOG0003078
OrthoInspector	1	1.000	-	-		otm48396
Panther	1	1.100	-	-	O	PTHR46022
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2737
SonicParanoid	1	1.000	-	-		X2446
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.110