DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ptc and ptch1

DIOPT Version :9

Sequence 1:NP_523661.2 Gene:ptc / 35851 FlyBaseID:FBgn0003892 Length:1286 Species:Drosophila melanogaster
Sequence 2:XP_031746817.1 Gene:ptch1 / 100492061 XenbaseID:XB-GENE-488222 Length:1436 Species:Xenopus tropicalis


Alignment Length:1388 Identity:507/1388 - (36%)
Similarity:761/1388 - (54%) Gaps:162/1388 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 PRVPDTHGDVVDEKLF-----SDLYIRTSWVDAQVALDQIDKGKARGSRTAIYLRSVFQSHLETL 66
            |||....|....|:..     .|...|.|:.||..||.||.:|||.|.:..::||:.||..|..|
 Frog    20 PRVVRRRGRSRGERRIVAPPDQDYLQRPSYCDANFALQQISEGKATGRKAPLWLRAFFQRQLFKL 84

  Fly    67 GSSVQKHAGKVLFVAILVLSTFCVGLKSAQIHSKVHQLWIQEGGRLEAELAYTQKTIGEDESATH 131
            |..:||:.||.|.|.:|:...|.|||::|.:.:.|.:||::.|||:..||.||::.|||:.....
 Frog    85 GCYIQKNCGKFLVVGLLIFGAFAVGLRAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNP 149

  Fly   132 QLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFEGIYYIEQI 196
            ||:|||..:..|:||..:|||.||...::||.|:|::|:..|.|..:| ..|........|:.||
 Frog   150 QLMIQTPLEDGANVLTTEALLQHLHSALEATKVQVYMYNKPWKLEKLC-FKSGELITEAGYVSQI 213

  Fly   197 LRHLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQRLLWTTLNPASVMQYMKQKMSEEKISFDF 261
            :..|.||.|||||||||||::|  ......:|| ...|.||..:|..:::.:|      |.....
 Frog   214 IESLYPCLIITPLDCFWEGAKL--HSGMAYMPG-KGFLQWTNFDPLGLLEELK------KGKLHI 269

  Fly   262 ETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEE 326
            :|.|:.:.:|.:|.|||::|||||.:..||:||||||||:|.||..||:|||||.:.|:|||.||
 Frog   270 DTWEEMINKAEVGHGYMDRPCLNPSDDKCPNTAPNKNSTKPVDVALILNGGCYGLSRKYMHWQEE 334

  Fly   327 LIVGGAKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNAWQRNFSR 391
            ||:||..:|.||....|.|||::.||||.|:||:.::...:|.|:.|.::|||.:|.||||.:.:
 Frog   335 LIIGGTVKNASGQSVSALALQTMFQLMTPKQMYEHFKGYEEVSHINWNEDKAAAILEAWQRTYVQ 399

  Fly   392 EVEQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRG 456
            .|.|.:.:.|    :..:..|::..|||||..||..|.:.:..|..:.:.||..|:||| |..:.
 Frog   400 VVHQSVPQNS----SQKVLPFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRW-DCAKS 459

  Fly   457 QSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYAES--NRR 519
            |.:||:|||||:..|.||||||.:|:||.||||:|||:||||||:|||.:|:|..|::|:  |:|
 Frog   460 QGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKR 524

  Fly   520 ----EQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAM 580
                ::|...||:.|.|:..::.|...:||.||.||:|||:.|.||||:|:..|.|..||:|||:
 Frog   525 IPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAI 589

  Fly   581 ISLDLRRRTAGRADIFCC-CFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNN----------- 633
            :|:||.||...|.||||| ..|......::.|.....||:|.|.:..|...:::           
 Frog   590 LSMDLYRREVRRLDIFCCFSSPCVSRVIQIEPQAYTDNNDNTRYSPPPPYSSHSFAHETQITMQS 654

  Fly   634 ----RVPLPAQNPL----LEQRADI----------------PGSSHS----LASFS--------- 661
                |.....:..|    .|.|::|                |.|:.|    |:.||         
 Frog   655 TVQLRTEYDPRTQLYYTTAEPRSEISVQPAAPSPQDVSGQTPESTSSTRDLLSPFSESGVHCIEP 719

  Fly   662 ------LATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDSNEHKF 720
                  |::||.:||.|||::...|...::.|||.|..|||.:||::||||:.|:||:::.|:.|
 Frog   720 PCTKWTLSSFAEKHYAPFLLKPNTKVAVILVFLALLSVSLYGTTRVRDGLDLTDIVPRETREYDF 784

  Fly   721 LDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGN 785
            :..|.:.|.||.||.||| ..:||..|:||.:.|.||..|.:|:...|..||..||..|.:||..
 Frog   785 IATQFKYFSFYHMYVVTQ-KADYPRAQRLLYELHKSFAGVKYVLLEGNKQLPRMWLHYFRDWLQG 848

  Fly   786 LQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIINQRA 850
            ||..||.|:..|::|... :.|||.||:|||||::|||:.|.|::...:...|||::||||...|
 Frog   849 LQDTFDREWEAGKITHND-YRNASDDAVLAYKLLIQTGNSDKPINLNQLTKQRLVDTDGIIQPNA 912

  Fly   851 FYNYLSAWATNDVFAYGASQGKLYPEPRQYFH-----QPNEYDLKIPKSLPLVYAQMPFYLHGLT 910
            ||.||:||.:||..||.|||..:.|.|.::.|     :|....::..:  |:.|.|.||||:||.
 Frog   913 FYIYLTAWVSNDPVAYAASQANIRPHPPEWLHDKADDRPETRTIRAAE--PIEYVQFPFYLNGLR 975

  Fly   911 DTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSLLL 975
            :||.....|..:|.:...|...|:.:||:|.||:|||||:.||..|.:.::.||....::.::.|
 Frog   976 ETSDFVEAIEKVRAICNNYTSLGVSSYPNGYPFLFWEQYIGLRHWLLLSISVVLACTFLVCAVFL 1040

  Fly   976 LSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGNRQ 1040
            |:.|.|.::::.:.....::||.|.|:||||||:|.||||.|||:.:.|.|.::|.|:|::|::.
 Frog  1041 LNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKN 1105

  Fly  1041 RRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSM 1105
            ||..|:::....|::.|.:::.:.|.||:.|.|:|::|:|..:|.::..:|..|.|::.|:|||.
 Frog  1106 RRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTLLGVLNGLVLLPVLLSY 1170

  Fly  1106 VGPEAELVPLEHPDRISTPS------------PLPVRSSKRSGKS-----YVVQG---------- 1143
            .||..|:.|....||:..|.            |.|.::...|..|     ..|.|          
 Frog  1171 FGPYPEVSPTNGRDRLEFPQEPPPNIVRFPVHPRPTQNGSDSSDSEYSSQTTVSGISEELHQYDS 1235

  Fly  1144 ---SRSSRG----------------SCQKSHHHHHKDLNDPSLTTITEEP---QSWKSSNSSIQM 1186
               ||:|..                :.|:::.|:..:.|.|.    .:||   |.|:|:      
 Frog  1236 QQCSRASTNQVFLEARRNPAFPRSTAVQQNNRHNPPNQNTPP----NQEPRTQQQWRSN------ 1290

  Fly  1187 PNDWTYQPREQR-PASYAAPPPAY---HKAAAQQHHQHQGPPTTPPPPFPTAYPPELQSIVVQPE 1247
                    |.|| .::..:.||.|   ..|.|....:|.||.|:.......::...::.....|.
 Frog  1291 --------RNQRWDSTEGSRPPPYRPRRDAFASSTEEHAGPSTSRDRSGHRSHSHNMRKTAFAPG 1347

  Fly  1248 VTVETTHSDSNTTKVTATANIKV 1270
            ......:....|| |||:|::.|
 Frog  1348 GASVPAYGQPITT-VTASASVTV 1369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ptcNP_523661.2 2A060602 17..1134 CDD:273338 467/1199 (39%)
MMPL 454..598 CDD:304422 77/149 (52%)
ptch1XP_031746817.1 2A060602 37..1198 CDD:273338 464/1179 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 292 1.000 Domainoid score I1500
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H223
Inparanoid 1 1.050 850 1.000 Inparanoid score I431
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1190129at2759
OrthoFinder 1 1.000 - - FOG0003078
OrthoInspector 1 1.000 - - otm48396
Panther 1 1.100 - - LDO PTHR46022
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2737
SonicParanoid 1 1.000 - - X2446
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
99.190

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