Protein Alignment ptc and ptchd3a

DIOPT Version :9

• Sequence 1: NP_523661.2
• Gene: ptc / 35851
• FlyBaseID: FBgn0003892
• Length: 1286
• Species: Drosophila melanogaster
• Sequence 2: XP_003201375.2
• Gene: ptchd3a / 100334931
• ZFINID: ZDB-GENE-111215-6
• Length: 980
• Species: Danio rerio
• Alignment Length: 874
• Identity: 168/874 - (19%)
• Similarity: 323/874 - (36%)
• Gaps: 282/874 - (32%)

  Fly   329 VGGAKRNRSGHLRKAQALQSVVQLMTE-KEMYDQWQDNY-------------KVHHLGWTQEKAA 379
            |||...| |..::.|::::....|..: :...|.|.:.:             ||.|
Zfish   194 VGGVNLN-SSIIKSAKSVRLFYFLKEDNRTRTDLWLNEFLKVFPSNLSLNSIKVTH--------- 248

  Fly   380 EVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVIGVAVTVLYAF 444
                  ..:.||:||                  ..|...|::..||    ::.||.:|.::|
Zfish   249 ------STSLSRQVE------------------FEANTKDVIPLFS----ITYVIAIAFSIL--- 282

  Fly   445 CTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGI--VFNAASTQVVPFLALGLGVDHIF 507
             :.||: |.||.:..|...||.....:..:..|:...:|:  |...|::   |||.||:|||.:|
Zfish   283 -SCLRF-DCVRNKVWVATFGVFSAGLAVLSSFGMMLHIGVPFVMTVANS---PFLILGIGVDDMF 342

  Fly   508 MLTAAYAESN--RREQTKL--ILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCL--QAAIVM 566
            :|.:.:.::|  .|.:|:|  ..|:...||..:..:...:|:.....|..:::.|||  ..:|:.
Zfish   343 ILISCWQQTNVHDRVETRLSNTYKEAAISITITTLTDVLAFYIGLMTPFRSVRSFCLYTSTSILF 407

  Fly   567 CSNLAAALLVFPAMISLDLRRRTAGRADIFC-----------------CCFPVWKEQPKVAPPVL 614
            |  ...::..|.|.:.|:.||..:.:..:.|                 ||.
Zfish   408 C--YIYSITFFGAFLVLNGRRENSNKHWLTCKEVPEECAVGQSKWYELCCI-------------- 456

  Fly   615 PLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRADIPGSSHSLASFSLATFAFQHYTPFLMRSWV 679
                 .|...||..|                  .::...:|         |..::|.|||.:||.
Zfish   457 -----GGAYDRHTGS------------------EEVQPMNH---------FFKKYYGPFLTKSWT 489

  Fly   680 KFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFY--SMYAVTQGNFE 742
            |...::.:...||.|:|...::|:|:|:.:|...||...|:.|.:...|..|  ::..|.:..|.
Zfish   490 KVFVIVFYCIYLIVSIYGCFQIQEGIDLRNLAADDSYVVKYYDNEKAYFSEYGPNIMVVIRQEFP 554

  Fly   743 YPTQQQL--LRDYHDSFVRVPHVIKNDNGGLPDFWLL-----------------LFSEWLGNLQK 788
            |..::.:  |....:.|..:..:.|:    :...|:.                 :|.|.||...:
Zfish   555 YWDEKYMSDLETCIEDFKNLSFIEKD----IFTSWIKSYKYYGYHTKLNLSAEDVFKENLGTFLR 615

  Fly   789 IFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIINQRAFYN 853
            .:.:..:|         .|.::::|.|.:..:||.::...:| |:.:.|:
Zfish   616 FYSDFKQD---------VNFTNNSIHASRFFIQTVNISTALD-EMNMLNK--------------- 655

  Fly   854 YLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYDLKIPKSLPLVYAQMPFYLHGLTDTSQ---I 915
                                                                   |.||:|   :
Zfish   656 -------------------------------------------------------LRDTAQKCPV 665

  Fly   916 KTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRS----SLAMILACVLLAALVLVSLLLL 976
            ..|:.|                |:   ||:.:||..:.:    ::|:..|.:||.:|:|:...|.
Zfish   666 PLLVYH----------------PA---FIYHDQYAVIVTNTIQNIAVTTAVMLLISLLLIPNPLC 711

  Fly   977 SVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGNRQR 1041
            |:|    |..|:.:.:..:.|.|.|..:.|..|..:||::.:|..:.|:..||..|:::......
Zfish   712 SLW----VTFSIASVIVGVTGFMALWDVNLDTISMIILVVCIGFSVDFSAHISYAFVSNKKPSAN 772

  Fly  1042 RVQLSMQMSLG-PLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSM 1105
            ...:....:|| |::.|.:::.:.|.:||.|. .::.|.|..::.:|:..|..:.|...|:.|:.
Zfish   773 EKAVEALFNLGYPILQGAVSTILGVVVLSASK-NYIFRTFFKIMFLVIFFGLFHGLTFIPVFLTF 836

  Fly  1106 V------------GPEAELVPLEHPDRIS 1122
            .            |||.:.:...:.:.|:
Zfish   837 FDMCNGTPAENKSGPEEQAMKKSYTNNIA 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	168/874 (19%)
		MMPL	454..598	CDD:304422	39/168 (23%)
ptchd3a	XP_003201375.2	Patched	60..838	CDD:280598	164/845 (19%)
		MMPL	289..432	CDD:304422	38/147 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910