Protein Alignment Gle1 and GLE1

DIOPT Version :10

• Sequence 1: NP_610400.1
• Gene: Gle1 / 35849
• FlyBaseID: FBgn0033316
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_010074.1
• Gene: GLE1 / 851320
• SGDID: S000002366
• Length: 538
• Species: Saccharomyces cerevisiae
• Alignment Length: 629
• Identity: 137/629 - (21%)
• Similarity: 239/629 - (37%)
• Gaps: 164/629 - (26%)

  Fly    55 ESPAPEPNNEIPLLPKIDFEPNISCFPDLQAINASIVRRE-LEEEGKRCVRQQLKAIRDKQDAMR 118
            :.|.|||:..|.|       |:.:.....:.:|.|:|..: ..|...|.:..|.|.|...:..:.
Yeast    31 QCPTPEPSPAIKL-------PSFTKVGTKKLVNESVVILDPALENALRDLNLQSKLIPINEPIVA 88

  Fly   119 LS-----RETQQRKEERQRDQLQQKALRERNESLLIQKADQMTAAQLEAQQREQLALRQQIDQKL 178
            .|     ..|...........|...|           |....||..||       |:.:...:|:
Yeast    89 ASSIIVPHSTNMPLPRASHSSLLDNA-----------KNSNATAPLLE-------AIEESFQRKM 135

  Fly   179 HKLALEGVSRCQRRFNQKYEGIAKILLSLNPETVKVCAAQNTQLKELGQKFEQLVSSVKMGNCEM 243
            ..|.|.         |||                     :...::|..::.|           |.
Yeast   136 QNLVLA---------NQK---------------------EIQSIRENKRRVE-----------EQ 159

  Fly   244 QSQFLCSIIKAEEFCKSLDALELDIIKQLAEFSEQIQQQLKMEAAKKLEDERQR--------QQQ 300
            :.:      |.||..|..:|            .|:.:::.::...||.|:||:|        ||:
Yeast   160 RKR------KEEEERKRKEA------------EEKAKREQELLRQKKDEEERKRKEAEAKLAQQK 206

  Fly   301 QEEERQKLEEQQKLEEQEKLRKEKEESAAKEKQQEAETAKADAANVPAPLEPKSQDVPPAATATS 365
            |||||:|:|||.  |::.:|:||.|   ||..||:.:..||                     .|:
Yeast   207 QEEERKKIEEQN--EKERQLKKEHE---AKLLQQKDKLGKA---------------------VTN 245

  Fly   366 TSVHPDRLKFYNDILALYQSKVDAVKPL-QTEESLKQYRTGCQRAINLPLNAISAVSPQHLAQNF 429
            ..........|.|.:|  |.|.|.|.|: :.:.:::...:..:|.||.....::. |.|.|.:..
Yeast   246 FDKISKMFWHYKDKIA--QIKQDIVLPIKKADVNVRNLLSRHKRKINPKFGQLTN-SNQQLFKIQ 307

  Fly   430 DKLYSFFAGQPTKVMNGTITINDHPLARDYCMLLMAKKFVSQTETAICSNPQAAFPFASVIITFW 494
            ::|        |:::|.|   ....||..:.:..:||..|.|.||.:...|::|.|...:.:...
Yeast   308 NEL--------TQLINDT---KGDSLAYHWILNFIAKAVVHQAETEVRVKPESALPLGKLTLYLL 361

  Fly   495 KLLPDFGKVFLAYMYKESPFLVPYV--IPQQQGQTPEQYLKTIGYRLTDKNELEKPDIYLKRQTG 557
            ...|:..::|:|.:.|:.||::.:.  |..::|:      :.:|::..::|:.|....|.:|..|
Yeast   362 VQFPELQELFMARLVKKCPFVIGFTCEIDTEKGR------QNMGWKRNNENKWEDNTSYDERMGG 420

  Fly   558 LARLYAAVIISQGRKAAGPDEC-------FELNEGWLWLAHMVHVKPLPDISAT---LIMEILQT 612
            :..|:|.:     .:...|.|.       |.:...|..||.:.:. ||..|:.|   ::......
Yeast   421 ILSLFAII-----TRLQLPQEFITTTSHPFPIALSWHILARICNT-PLNLITNTHFVILGSWWDA 479

  Fly   613 LGFELWRTYGKQFVKLLVYIQNIYMPQLAAYDEGGPKTRLEMLL 656
            ...:..:.||.|..|||:.|......::|.....| ..||.:||
Yeast   480 AAVQFLQAYGNQASKLLILIGEELTSRMAEKKYVG-AARLRILL 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gle1	NP_610400.1	Smc	<82..>232	CDD:440809	26/155 (17%)
		EnvC	104..>365	CDD:443969	56/273 (21%)
		GLE1	394..633	CDD:462280	53/250 (21%)
GLE1	NP_010074.1	GLE1	273..499	CDD:462280	53/249 (21%)