DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gle1 and Gle1

DIOPT Version :9

Sequence 1:NP_610400.1 Gene:Gle1 / 35849 FlyBaseID:FBgn0033316 Length:677 Species:Drosophila melanogaster
Sequence 2:NP_083199.1 Gene:Gle1 / 74412 MGIID:1921662 Length:699 Species:Mus musculus


Alignment Length:677 Identity:182/677 - (26%)
Similarity:314/677 - (46%) Gaps:117/677 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 RKTPEPPLPEESPAPEPNNEIPLLPKIDFEPNISCFPDLQAINASIVRRELEEEGKRCVRQQLKA 109
            |.:|:.|.|......:..:|.|....|  .|..|              |.::.||  |:|....|
Mouse    94 RSSPQSPSPSSPNGTQSTHESPFTEPI--APQSS--------------RAIKVEG--CIRMYELA 140

  Fly   110 IRDK-QDAMRLSRETQQRK---------EERQR-DQLQQKALRERNESL--LIQKADQMTAAQLE 161
            .|.: .:.:|..:|.|:||         |:.:| |:|::..|.:..:.|  :::|:.:......|
Mouse   141 HRMRGTEGLRQWQEEQERKVRALSEMASEQLKRFDELKELKLHKEFQDLQEVMEKSTREALGHQE 205

  Fly   162 AQQREQLALRQQIDQKLHKLALEGVSRCQRRFNQKYEGIAKI--LLSLNPETVKVCAAQNTQLKE 224
            ..:.|.....:.::.||.:...:.|.:.::...:|.||..::  |.||..|.:::    |.||..
Mouse   206 KLKEEHRHRAKILNLKLREAEQQRVKQAEQEQLRKEEGQVRLRSLYSLQEEVLQL----NQQLDA 266

  Fly   225 LGQKFEQLVSSVKMGNCEMQSQFLCSIIKAEEFCKSLDALELDIIKQLAEFSEQIQQQLKMEAAK 289
            ..|..|.|  ||.:...:.:...||.:|.:             ||:                  .
Mouse   267 SSQHKELL--SVDLAAFQTRGNQLCGLISS-------------IIR------------------T 298

  Fly   290 KLEDERQRQQQQEEERQKLEEQQKL---EEQEKLR----KEKEESAAKEKQQEAETAKADA---- 343
            .||......:.|.|..:.|:|.:.|   .|||..|    |:|.|..||.|:||::..:..|    
Mouse   299 TLESGYPTAENQAEAERALQEMRDLLSDLEQEITRASQVKKKHEEEAKVKRQESQVQQGPAPPTQ 363

  Fly   344 --ANVPAPLEPKSQDVPPAATATSTSVHPDRLKFYNDILALYQSKVDA-VKPLQTEESL------ 399
              |..|:|:..:::|:              ::|..:..:..||...|| .|.:...|.|      
Mouse   364 TSAPSPSPVGAQNEDL--------------QVKVQDSTMQWYQQLQDASAKCVLAFEDLTSSKDS 414

  Fly   400 --KQYRTGCQRAINLPLNAISAVSPQHLAQNFDKLYSFFAGQPTKVMNGTITINDHPLARDYCML 462
              |:.:...|:|..:|::.||.::...|.:.|||::|..:|:|.:....::::..:|...|:...
Mouse   415 QTKKIKMDLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQY 479

  Fly   463 LMAKKFVSQTETAICSNPQAAFPFASVIITFWKLLPDFGKVFLAYMYKESPFLVPYVIPQQQGQT 527
            .:|:|||.|.|..:.|:.:||||.|.|....|.|.|..|.:.||:::|:.|:.||:....::|..
Mouse   480 KLAEKFVKQGEEEVASHHEAAFPIAVVASGIWMLHPKVGDLILAHLHKKCPYSVPFYPAFKEGMA 544

  Fly   528 PEQYLKTIGYRLTDKNELEKPDIYLKRQTGLARLYAAVIISQ----GRKAAGPDECFELNEGWLW 588
            .|.|.:.:||::|| :::|:.|.:|||.:|:.|||||:|..|    .|:.|.|   ..||.||.|
Mouse   545 LEDYQRMLGYQVTD-SKVEQQDNFLKRMSGMIRLYAAIIQLQWPYGNRQEAHP---HGLNHGWRW 605

  Fly   589 LAHMVHVKPLPDISATLIMEILQTLGFELWRTYGKQFVKLLVYIQNIYMPQLAAYDEGGPK---T 650
            ||.:::::||.|::|||:.:.|:..|..|.:.|..||.|:::.|:..|.|::.|....|..   .
Mouse   606 LAQVLNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMILLIKEDYFPRIEAITSSGQMGSFI 670

  Fly   651 RLEMLLAKFLRERQIAQAVGVLPPGFW 677
            ||:..|.|.|:.|:|....|.|...||
Mouse   671 RLKQFLEKCLQRREIPVPRGFLTTSFW 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gle1NP_610400.1 COG4026 <82..>200 CDD:226513 26/130 (20%)
GLE1 384..631 CDD:369538 87/259 (34%)
Gle1NP_083199.1 Interaction with NUP155. /evidence=ECO:0000250 1..29
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 62..123 7/28 (25%)
iSH2_PI3K_IA_R 169..>288 CDD:304922 31/132 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 334..374 12/46 (26%)
GLE1 410..648 CDD:285108 77/250 (31%)
Mediates the shuttling between the nucleus and the cytoplasm. /evidence=ECO:0000250 445..484 12/46 (26%)
Interaction with NUPL2. /evidence=ECO:0000250 657..699 12/44 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167849726
Domainoid 1 1.000 158 1.000 Domainoid score I4127
eggNOG 1 0.900 - - E1_KOG2412
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 209 1.000 Inparanoid score I3671
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003814
OrthoInspector 1 1.000 - - oto94729
orthoMCL 1 0.900 - - OOG6_103111
Panther 1 1.100 - - LDO PTHR12960
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R492
SonicParanoid 1 1.000 - - X4260
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.780

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