DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gle1 and gle1

DIOPT Version :9

Sequence 1:	NP_610400.1	Gene:	Gle1 / 35849	FlyBaseID:	FBgn0033316	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_005166804.1	Gene:	gle1 / 445408	ZFINID:	ZDB-GENE-040831-4	Length:	717	Species:	Danio rerio

Alignment Length:	706	Identity:	180/706 - (25%)
Similarity:	319/706 - (45%)	Gaps:	114/706 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AATLRNA----ALASATCTGRTLGEDREPIWVEGSRKTPEPPLPEESPAPEPNNEIPLLPKIDFE 74
            ||..|:|    .|..::|:...:....|.   |..::..:..:..|:||..|...:...|.:..
Zfish    82 AAVCRSAPISPRLKRSSCSLPAVSIQTEE---EEEKEKEKAEVVAEAPAVSPEASVSTPPAVSV- 142

  Fly    75 PNISCFPDLQAINASIVRRELEEEGKRCVRQQLKAIRDKQD---AMRLSRETQQRKEERQRDQLQ 136
                ..|....|:..|  |..|::.|...:.:|...:::|:   |...:.|::|.|...:..:|:
Zfish   143 ----LSPRATQISGCI--RMCEQKHKAKAKMELSLRQEQQERLVATVANHESEQLKRFEEFMELK 201

  Fly   137 QK----ALRERNESLLIQKADQMTAAQ--LEAQQREQ-----LALRQQIDQKLHKLALEGVSRCQ 190
            |:    ::|:.||    ::|.:....|  |..:.|.:     |.||:...|:|.::.||...:.:
Zfish   202 QRQEHQSIRDTNE----KEAQESLGRQEKLREEHRHRMKILNLRLREMEQQRLREVELERQRQVE 262

  Fly   191 RRFNQKYEGIAKILLSLNPETVKVCAAQNTQLKELGQKFEQLVSSVKMGNCEMQSQFLCSIIK-- 253
            .|  :::..|..|     .|.|       .||..|.|..:...:.|:......:...|||.:.
Zfish   263 GR--ERHRAINAI-----QEEV-------LQLNRLLQPQQSTHAEVEHAPYITRGNQLCSQLSEV 313

  Fly   254 ----AEEFCKSLDALELDIIKQLAEFSEQIQQQLK------MEAAKKLEDERQRQQQQEEERQKL 308
                |::...|::.|.:         :|:..|:::      .||..:..:.:::::|:|||.::.
Zfish   314 VPAAADDQFPSVEDLSV---------AERALQEMRSLVRSLQEAVSQAAERKKKKEQEEEEEKRR 369

  Fly   309 EEQQKLEEQEKLRKEKEESAAKEKQQEAETAKADAANVPAPLEPKSQDVPPAATATSTSVHPDRL 373
            :||.|.:::|  :|:....:||||      ||.:                    ...|......|
Zfish   370 QEQLKAQQEE--QKKSAALSAKEK------AKKE--------------------GLQTGADDSTL 406

  Fly   374 KFYNDILALYQSKVDAVKPLQ--TEESLKQYRTGCQRAINLPLNAISAVSPQHLAQNFDKLYSFF 436
            |:||.:..|......|...|.  .:...|:.:...|:|...|::.|:..|...|.:.|:|:....
Zfish   407 KWYNSLQDLANQCAQAFDDLNKAKDTQTKKIKMELQKAATTPVSQIANSSGAPLKEAFEKIDKLL 471

  Fly   437 AGQPTKVMNGTITINDHPLARDYCMLLMAKKFVSQTETAICSNPQAAFPFASVIITFWKLLPDFG 501
            :|:|......|::.:.||...::....:|:|||.|.|..:.||..||||..:|....|:|.|..|
Zfish   472 SGRPVTSAGKTVSTSQHPQGLEFASYRLAEKFVKQGEEEVASNHSAAFPIGAVASGIWELHPKIG 536

  Fly   502 KVFLAYMYKESPFLVPYVIPQQQGQTPEQYLKTIGYRLTDKNELEKPDIYLKRQTGLARLYAAVI 566
            .:.||:::|:.|:.||:..|.:.|.:.|.|.|.:|||: |:.::|..|.:|||.:|:.|||||:|
Zfish   537 DLILAHLHKKCPYAVPHYPPMESGTSVEDYQKILGYRV-DEGKVEGQDSFLKRMSGMIRLYAAII 600

  Fly   567 -------ISQGRKAAGPDECFELNEGWLWLAHMVHVKPLPDISATLIMEILQTLGFELWRTYGKQ 624
                   ..||....|      ||.||.|:|.:::::||.||:||::.:.|:..|..|.:.|..|
Zfish   601 QMRWPYSSKQGPHPHG------LNHGWRWMAQILNMEPLADITATILFDFLEVCGNALMKQYRVQ 659

  Fly   625 FVKLLVYIQNIYMPQLAAYDEGGPK---TRLEMLLAKFLRERQIAQAVGVLPPGFW 677
            |.||::.|...|.|::.|....|..   |||:..|...||.:||......|...|:
Zfish   660 FWKLILIINEEYFPRIEAVTSAGQMGSVTRLKQFLETSLRTKQIPAPKSELGSAFF 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gle1	NP_610400.1	COG4026	<82..>200	CDD:226513	28/131 (21%)
Gle1	NP_610400.1	GLE1	384..631	CDD:369538	83/255 (33%)
gle1	XP_005166804.1	iSH2_PI3K_IA_R	172..283	CDD:304922	28/128 (22%)
gle1	XP_005166804.1	GLE1	414..666	CDD:285108	84/258 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595508
Domainoid	1	1.000	149	1.000	Domainoid score	I4371
eggNOG	1	0.900	-	-		E1_KOG2412
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3903
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003814
OrthoInspector	1	1.000	-	-		oto39260
orthoMCL	1	0.900	-	-		OOG6_103111
Panther	1	1.100	-	-	LDO	PTHR12960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R492
SonicParanoid	1	1.000	-	-		X4260
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.780