DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gle1 and Gle1

DIOPT Version :9

Sequence 1:	NP_610400.1	Gene:	Gle1 / 35849	FlyBaseID:	FBgn0033316	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001020902.1	Gene:	Gle1 / 362098	RGDID:	1307329	Length:	698	Species:	Rattus norvegicus

Alignment Length:	685	Identity:	177/685 - (25%)
Similarity:	325/685 - (47%)	Gaps:	94/685 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ASATCTGRTLGEDREPIWVEGSRKTPEPPLPEESPAPEPNNEIPLLPKIDFEPNISCFPDLQAIN 87
            :|.:.:|......:.|:     |.:|:.|.|......:..:|.|             |.:..|:.
  Rat    76 SSGSASGLYQSTLKSPV-----RSSPQSPSPSTPSGTQSAHESP-------------FTEPIALQ 122

  Fly    88 ASIVRRELEEEGKRCVRQQLKAIRDK-QDAMRLSRETQQRK---------EERQR-DQLQQKALR 141
            :|   |.::.||  |:|....|.|.: .:.:|..:|.|:||         |:.:| |:|::..|.
  Rat   123 SS---RAIKVEG--CIRMYELAHRMRGTEGLRQWQEEQERKVQALSEMASEQLKRFDELKELKLH 182

  Fly   142 ERNESL--LIQKADQMTAAQLEAQQREQLALRQQIDQKLHKLALEGVSRCQRRFNQKYEGIAKI- 203
            :....|  :::|:.:......|..:.|.....:.::.||.:...:.|.:.::...:|.||..::
  Rat   183 KEFRDLQEVMEKSTREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQEQLRKEEGQIRLR 247

  Fly   204 -LLSLNPETVKVCAAQNTQLKELGQKFEQLVSSVKMGNCEMQSQFLCSIIKAEEFCKSLDALELD 267
             |.:|..|.:::    |.||....|..:.|  :|.:...:.:...||.:|..
  Rat   248 SLYTLQEEVLQL----NQQLDASSQHKDLL--NVDLAAFQTRGNQLCGLISG------------- 293

  Fly   268 IIKQLAEFSEQIQQQLKMEAAKKLEDERQRQQQQEEERQKLEEQQKLEEQEKLRKEKEESAAKEK 332
            ||:...| |.....:.:.||.:.|::.|......|:|..:..|.:|.:|:|          |:.|
  Rat   294 IIRTTLE-SGYPTAENQAEAERVLQEMRDLLSNLEQEITRASEMKKKDEEE----------ARVK 347

  Fly   333 QQEAETAKADAA----NVPAP--LEPKSQDVPPAATATSTSVHPDRLKFYNDILALYQSKVDAVK 391
            .||::..:...|    :.|:|  :..:|:|:       ...|....:::|..:.......|.|.:
  Rat   348 LQESQVQQGPGAPTKTSAPSPSLVGTQSEDL-------QVKVQDSTMQWYQQLQDASAKCVLAFE 405

  Fly   392 PLQT--EESLKQYRTGCQRAINLPLNAISAVSPQHLAQNFDKLYSFFAGQPTKVMNGTITINDHP 454
            .|.:  :..:|:.:...|:|..:|::.||.::...|.:.|||::|..:|:|.:....::.:..:|
  Rat   406 DLTSSKDSQIKKIKMDLQKAATIPVSQISTIAGSKLKEVFDKIHSLLSGKPVQSGGRSVCVTLNP 470

  Fly   455 LARDYCMLLMAKKFVSQTETAICSNPQAAFPFASVIITFWKLLPDFGKVFLAYMYKESPFLVPYV 519
            ...|:....:|:|||.|.|..:.|:.:||||.|.|....|.|.|..|.:.||:::|:.|:.||:.
  Rat   471 QGLDFVQYKLAEKFVKQGEEEVASHHEAAFPIAVVASGIWMLHPKVGDLILAHLHKKCPYSVPFY 535

  Fly   520 IPQQQGQTPEQYLKTIGYRLTDKNELEKPDIYLKRQTGLARLYAAVIISQ----GRKAAGPDECF 580
            ...::|...|.|.:.:||::|| :::|:.|.:|||.:|:.|||||:|..|    .|:.|.|   .
  Rat   536 PAFKEGMPLEDYQRMLGYQVTD-SKVEQQDNFLKRMSGMIRLYAAIIQLQWPYGSRQEAHP---H 596

  Fly   581 ELNEGWLWLAHMVHVKPLPDISATLIMEILQTLGFELWRTYGKQFVKLLVYIQNIYMPQLAAYDE 645
            .||.||.|||.:::::||.|::|||:.:.|:..|..|.:.|..||.|:::.|:..|.|::.|...
  Rat   597 GLNHGWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMILLIKEDYFPRIEAITS 661

  Fly   646 GGPK---TRLEMLLAKFLRERQIAQAVGVLPPGFW 677
            .|..   .||:..|.|.|:.|:|....|.|.|.||
  Rat   662 SGQMGSFIRLKQFLEKCLQRREIPVPKGFLTPSFW 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gle1	NP_610400.1	COG4026	<82..>200	CDD:226513	28/130 (22%)
Gle1	NP_610400.1	GLE1	384..631	CDD:369538	84/252 (33%)
Gle1	NP_001020902.1	Interaction with NUP155. /evidence=ECO:0000250	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..119		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..374		10/40 (25%)
		GLE1	409..647	CDD:285108	74/243 (30%)
		Mediates the shuttling between the nucleus and the cytoplasm. /evidence=ECO:0000250	444..483		8/40 (20%)
		Interaction with NUPL2. /evidence=ECO:0000250	656..698		14/41 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353383
Domainoid	1	1.000	158	1.000	Domainoid score	I4016
eggNOG	1	0.900	-	-		E1_KOG2412
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	207	1.000	Inparanoid score	I3624
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003814
OrthoInspector	1	1.000	-	-		otm46101
orthoMCL	1	0.900	-	-		OOG6_103111
Panther	1	1.100	-	-	LDO	PTHR12960
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4260
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.750