Protein Alignment Gle1 and GLE1

DIOPT Version :10

• Sequence 1: NP_610400.1
• Gene: Gle1 / 35849
• FlyBaseID: FBgn0033316
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_011516851.1
• Gene: GLE1 / 2733
• HGNCID: 4315
• Length: 710
• Species: Homo sapiens
• Alignment Length: 748
• Identity: 187/748 - (25%)
• Similarity: 328/748 - (43%)
• Gaps: 157/748 - (20%)

  Fly    22 LASATCTGRTLG--------------------------EDREPIWVEGSRKTPEPPLPEESPAPE 60
            |.|.||...||.                          ::.:|:.......|....|.:.|..|:
Human    26 LVSHTCNPSTLDVLEECMSLPKLSSYSGWVVEHVLPHMQENQPLSETSPSSTSASALDQPSFVPK 90

  Fly    61 -PNNEIPLLPKIDFEPNISCFPDLQAINASIV---RRELEEEGKRCVRQQLKAIRDK-QDAMRLS 120
             |:......|.....||.:...|......|:|   .|.::.||  |||......|.| .:.:||.
Human    91 SPDASSAFSPASPATPNGTKGKDESQHTESMVLQSSRGIKVEG--CVRMYELVHRMKGTEGLRLW 153

  Fly   121 RETQQRK----EERQRDQLQQ----KALRERNESLLIQKADQMTAAQ-------LEAQQREQLAL 170
            :|.|:||    .|...:||::    |.|::..|...:::..:.::.:       |:|:.|.:..:
Human   154 QEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKI 218

  Fly   171 RQQIDQKLHKLALEGVSRCQRRFNQKYEGIAKI--LLSLNPETVKVCAAQNTQLKELGQKFEQLV 233
               ::.||.:...:.|.:.::...:|.||..::  |.:|..|.:     |.:|..:..::.:.|:
Human   219 ---LNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEML-----QLSQQLDASEQHKALL 275

  Fly   234 SSVKMGNCEMQSQFLCSIIKAEEFCKSLDALELDIIKQLAEFS-EQIQQQLKME-AAKKLED--- 293
             .|.:...:.:...|||:|..             ||:..:|.| ...:.|.:.| |.:::.|
Human   276 -KVDLAAFQTRGNQLCSLISG-------------IIRASSESSYPTAESQAEAERALREMRDLLM 326

  Fly   294 ----------ERQRQQQQEEERQKLEEQQKLEEQEKLRKEKEESAAKE----KQQEAETAKADAA 344
                      |.:|:|.:||.:.||:|.|.   |:.....||..|..:    ||.|
Human   327 NLGQEITRACEDKRRQDEEEAQVKLQEAQM---QQGPEAHKEPPAPSQGPGGKQNE--------- 379

  Fly   345 NVPAPLEPKSQDVPPAATATSTSVHPDRLKFYNDILALYQSKVDA-VKPLQTEESL--------K 400
                .|:.|.||:                     .:..||...|| ::.:.|.|.|        |
Human   380 ----DLQVKVQDI---------------------TMQWYQQLQDASMQCVLTFEGLTNSKDSQAK 419

  Fly   401 QYRTGCQRAINLPLNAISAVSP---------QHLAQNFDKLYSFFAGQPTKVMNGTITINDHPLA 456
            :.:...|:|..:|::.||.::.         ..|.:.|||::|..:|:|.:....::::..:|..
Human   420 KIKMDLQKAATIPVSQISTIADCRSLVFMAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQG 484

  Fly   457 RDYCMLLMAKKFVSQTETAICSNPQAAFPFASVIITFWKLLPDFGKVFLAYMYKESPFLVPYVIP 521
            .|:....:|:|||.|.|..:.|:.:||||.|.|....|:|.|..|.:.||:::|:.|:.||:...
Human   485 LDFVQYKLAEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGDLILAHLHKKCPYSVPFYPT 549

  Fly   522 QQQGQTPEQYLKTIGYRLTDKNELEKPDIYLKRQTGLARLYAAVIISQ----GRKAAGPDECFEL 582
            .::|...|.|.:.:||::.| :::|:.|.:|||.:|:.|||||:|..:    .|:...|   ..|
Human   550 FKEGMALEDYQRMLGYQVKD-SKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQEIHP---HGL 610

  Fly   583 NEGWLWLAHMVHVKPLPDISATLIMEILQTLGFELWRTYGKQFVKLLVYIQNIYMPQLAAYDEGG 647
            |.||.|||.:::::||.|::|||:.:.|:..|..|.:.|..||.|:|:.|:..|.|::.|....|
Human   611 NHGWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMLILIKEDYFPRIEAITSSG 675

  Fly   648 PK---TRLEMLLAKFLRERQIAQAVGVLPPGFW 677
            ..   .||:..|.|.|:.:.|....|.|...||
Human   676 QMGSFIRLKQFLEKCLQHKDIPVPKGFLTSSFW 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gle1	NP_610400.1	Smc	<82..>232	CDD:440809	37/170 (22%)
		EnvC	104..>365	CDD:443969	63/297 (21%)
		GLE1	394..633	CDD:462280	82/259 (32%)
GLE1	XP_011516851.1	Smc	<153..>365	CDD:440809	48/236 (20%)
		GLE1	413..661	CDD:462280	79/251 (31%)