DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cirl and ADGRE5

DIOPT Version :9

Sequence 1:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster
Sequence 2:NP_510966.1 Gene:ADGRE5 / 976 HGNCID:1711 Length:835 Species:Homo sapiens


Alignment Length:798 Identity:176/798 - (22%)
Similarity:300/798 - (37%) Gaps:174/798 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   345 VGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMA 409
            :|....|..||            .|.||:.  .:...|::..|   ||.:..|:|:.|      .
Human   137 LGSYTCQCLPG------------FKFIPED--PKVCTDVNECT---SGQNPCHSSTHC------L 178

  Fly   410 HKVNQRLRNFEPTWHPAT-----PDLTQCRSLWLNNLEMRVNQRDSSLI---------------- 453
            :.|........|.|.|..     |:.|.|..  ::......:|.|||.:                
Human   179 NNVGSYQCRCRPGWQPIPGSPNGPNNTVCED--VDECSSGQHQCDSSTVCFNTVGSYSCRCRPGW 241

  Fly   454 ----SIANDMSEVTSSKTLYGGDMLVTTKI------IQTVSEKMMHDKETFPDQRQREAMIMELL 508
                .|.|:..:....      ||..:|..      .||:|......::...|.:...|.:  .:
Human   242 KPRHGIPNNQKDTVCE------DMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEV--TI 298

  Fly   509 HCVVKTGSNLLD-----ESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVK 568
            ..|:|....|::     |:       |.|..:..:||.||:.||....:||.::.:.........
Human   299 QNVIKLVDELMEAPGDVEA-------LAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPS 356

  Fly   569 NILLSVRVLE--TKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESIL 631
            |..|::.:.|  .|.:...          .||.|::|..|......:.|.......:...:.::|
Human   357 NTELTLMIQERGDKNVTMG----------QSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLL 411

  Fly   632 KPSYDHFDLKSSRSYVRNTAILSN--DSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITL 694
            ..:       |...:.:..|.|..  :|.:...:: :||..:||..:|.:..|    :|:.||..
Human   412 ANA-------SLNLHSKKQAELEEIYESSIRGVQL-RRLSAVNSIFLSHNNTK----ELNSPILF 464

  Fly   695 TLKHLKTEN------------VTNP----TCVFWNYIDHA---WSANGCSLESTNRTHSVCSCNH 740
            ...||::.:            :..|    .|.||......   |:..||.:..:....:.|.|:|
Human   465 AFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSH 529

  Fly   741 LTNFAILM---DVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTS 802
            |::|||||   | |::.:.:|.|      |:.:.:|: .|::..::..|.::...|     :||:
Human   530 LSSFAILMAHYD-VEDWKLTLIT------RVGLALSL-FCLLLCILTFLLVRPIQG-----SRTT 581

  Fly   803 IYTSIYLCLLAIELLFLLGIEQT--ETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDEL 865
            |:..:.:||.....:||.|||..  :..:.|..:...||...|:...|...|....|.      |
Human   582 IHLHLCICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYF------L 640

  Fly   866 LLEVDQTPKVNCYY--LLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPV-LVF 927
            ::.|.|...::..:  |:.||:.|.:|.:|..|....|.:..||.| :....|..:|:.|| .:.
Human   641 VVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWL-DFEQGFLWSFLGPVTFII 704

  Fly   928 FVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMD 992
            ...|:.:....|.:..:.|......|   :|...|.....:...|.||...|....|..      
Human   705 LCNAVIFVTTVWKLTQKFSEINPDMK---KLKKARALTITAIAQLFLLGCTWVFGLFIF------ 760

  Fly   993 DDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRC--SK----TSIS 1051
            ||.:.|..|.|...|.|.|.::::.||:.|:|:|.||||:.        ||..  ||    ||.:
Human   761 DDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWA--------CLVAGGSKYSEFTSTT 817

  Fly  1052 SGIVTGNGPTAGTLCSVS 1069
            ||  ||:..|.....|.|
Human   818 SG--TGHNQTRALRASES 833

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CirlNP_001260807.1 Gal_Lectin 33..113 CDD:280328
GAIN 453..680 CDD:293098 44/261 (17%)
GPS 705..752 CDD:197639 17/56 (30%)
7tm_4 763..1014 CDD:304433 59/255 (23%)
ADGRE5NP_510966.1 EGF_CA 64..99 CDD:284955
EGF_CA 116..>148 CDD:214542 4/22 (18%)
EGF_CA 160..207 CDD:284955 13/55 (24%)
EGF_CA 209..243 CDD:284955 4/35 (11%)
GPS 493..536 CDD:280071 12/42 (29%)
7tm_2 544..782 CDD:278432 61/265 (23%)
ProP 608..>785 CDD:223553 44/192 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 814..835 9/22 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm40998
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12011
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.910

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