DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cirl and ADGRG7

DIOPT Version :9

Sequence 1:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster
Sequence 2:NP_116176.2 Gene:ADGRG7 / 84873 HGNCID:19241 Length:797 Species:Homo sapiens


Alignment Length:670 Identity:139/670 - (20%)
Similarity:255/670 - (38%) Gaps:155/670 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   438 LNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREA 502
            |..||.:|....:.|.:|::::..:||.......:.:  |...:.|.:.....:...|:.::   
Human   143 LETLEKQVKDVTAPLNNISSEVQILTSDANKLTAENI--TSATRVVGQIFNTSRNASPEAKK--- 202

  Fly   503 MIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQ-MRVA--------TSLLTGLE-YNAFLLADTI 557
                   ..:.|.|.|||.|          ||. .|||        |:|:..:| |:..|...::
Human   203 -------VAIVTVSQLLDAS----------EDAFQRVAATANDDALTTLIEQMETYSLSLGNQSV 250

  Fly   558 IRERSVVQKV----------KNILLSVRVLETKTIQSSVVFPDSDQWPLSSD-RIELPRAALIDN 611
            :.....:|..          .|:..||:...:.::.||..|..::...|:.| :.||  ..|::.
Human   251 VEPNIAIQSANFSSENAVGPSNVRFSVQKGASSSLVSSSTFIHTNVDGLNPDAQTEL--QVLLNM 313

  Fly   612 SEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVI 676
            ::.......|..           |.:..|..|:::...       ||            .:.|:|
Human   314 TKNYTKTCGFVV-----------YQNDKLFQSKTFTAK-------SD------------FSQKII 348

  Fly   677 SASLGKGRHIQ-LSQPITLTLKHLKTE-NVTNPTCVFWNYIDHAWSANGCSLESTNRTHSVCSCN 739
            |:...:....| .|..:..:.|:.:.| .:.:..||:||.....|...||..:........|.||
Human   349 SSKTDENEQDQSASVDMVFSPKYNQKEFQLYSYACVYWNLSAKDWDTYGCQKDKGTDGFLRCRCN 413

  Fly   740 HLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSI- 803
            |.||||:||....::|:.        ..:.|..::| |.:.:....||: :|..|..|..:||: 
Human   414 HTTNFAVLMTFKKDYQYP--------KSLDILSNVG-CALSVTGLALTV-IFQIVTRKVRKTSVT 468

  Fly   804 YTSIYLC--LLAIELLFLLGIEQTETSI----------------------------FCGFITIFL 838
            :..:.||  :|...|||:.|||.:..::                            .|..|...|
Human   469 WVLVNLCISMLIFNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALL 533

  Fly   839 HCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPK--VNCYYLLSYGLSLSVVAISLVIDPSTY 901
            |..:|....|....|...|..     |:..:...|:  :....|:.:|:...||||::.:   .|
Human   534 HYFLLVTFTWNALSAAQLYYL-----LIRTMKPLPRHFILFISLIGWGVPAIVVAITVGV---IY 590

  Fly   902 TQN--------DY-----C--VLMEANALFYA----TFVIPVLVFFVA-AIGYTFLSWIIMCRKS 946
            :||        ||     |  .:.|.|.:..:    :|::||.:..:: .:.:..:|..::.:.:
Human   591 SQNGNNPQWELDYRQEKICWLAIPEPNGVIKSPLLWSFIVPVTIILISNVVMFITISIKVLWKNN 655

  Fly   947 RTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLG 1011
            :....||:.:.:..:...:..:.||    ...|..||..|..   ||....|:.|.|..|||..|
Human   656 QNLTSTKKVSSMKKIVSTLSVAVVF----GITWILAYLMLVN---DDSIRIVFSYIFCLFNTTQG 713

  Fly  1012 LYIFVFHCIQNEKIRREYRK 1031
            |.||:.:.::.:..:.|..|
Human   714 LQIFILYTVRTKVFQSEASK 733

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CirlNP_001260807.1 Gal_Lectin 33..113 CDD:280328
GAIN 453..680 CDD:293098 43/247 (17%)
GPS 705..752 CDD:197639 17/46 (37%)
7tm_4 763..1014 CDD:304433 65/303 (21%)
ADGRG7NP_116176.2 GPS 383..422 CDD:197639 15/38 (39%)
7tmB2_GPR128 431..737 CDD:320385 69/328 (21%)
TM helix 1 433..458 CDD:320385 6/26 (23%)
TM helix 2 468..490 CDD:320385 7/21 (33%)
TM helix 3 527..554 CDD:320385 7/26 (27%)
TM helix 4 567..587 CDD:320385 6/19 (32%)
TM helix 5 621..651 CDD:320385 4/29 (14%)
TM helix 6 665..692 CDD:320385 5/30 (17%)
TM helix 7 699..724 CDD:320385 10/24 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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