DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and ADGRE3

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_115960.2	Gene:	ADGRE3 / 84658	HGNCID:	23647	Length:	652	Species:	Homo sapiens

Alignment Length:	763	Identity:	175/763 - (22%)
Similarity:	326/763 - (42%)	Gaps:	152/763 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 NLYWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSS 401
            :|:..:|:....:...||..|:.:....|..     :.||.........|.|..:..|.    :.
Human    15 SLFGAVTQKTKTSCAKCPPNASCVNNTHCTC-----NHGYTSGSGQKLFTFPLETCNDI----NE 70

  Fly   402 CEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSK 466
            |.||.|:....|....|.|.:::        |:.:....|... |::.|:  |..|...:.||||
Human    71 CTPPYSVYCGFNAVCYNVEGSFY--------CQCVPGYRLHSG-NEQFSN--SNENTCQDTTSSK 124

  Fly   467 TLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLN 531
            |..|      .|.:|.:.:|.                                 ||.|::.....
Human   125 TTEG------RKELQKIVDKF---------------------------------ESLLTNQTLWR 150

  Fly   532 PEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPL 596
            .|.:..::::            |.||:|:                :|:|.:::::..|:.....:
Human   151 TEGRQEISST------------ATTILRD----------------VESKVLETALKDPEQKVLKI 187

  Fly   597 SSDRIELPRAALIDN-SEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNT------AILS 654
            .:|.:.:...|:.|| ||           :|....|....:..|::.|.....:|      |.:|
Human   188 QNDSVAIETQAITDNCSE-----------ERKTFNLNVQMNSMDIRCSDIIQGDTQGPSAIAFIS 241

  Fly   655 NDS---DVNA---GEIQQRLRI-LNSKVISASLGKGRHIQLSQPITLTLKHLK-TENVTNPTCVF 711
            ..|   .:||   .|:.::.:: |||:|:||::|..|::.||:.:|||.:|:| |.:.....||:
Human   242 YSSLGNIINATFFEEMDKKDQVYLNSQVVSAAIGPKRNVSLSKSVTLTFQHVKMTPSTKKVFCVY 306

  Fly   712 WNYIDHA--WSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISI 774
            |......  ||.:||.|...|::|::|:|:||::||:||.:..:.:..:.|       :..|:.:
Human   307 WKSTGQGSQWSRDGCFLIHVNKSHTMCNCSHLSSFAVLMALTSQEEDPVLT-------VITYVGL 364

  Fly   775 GICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLH 839
            .:.::.:::|.||..|...  :::..||::..:.|||....||||:||::||..:.|..|...||
Human   365 SVSLLCLLLAALTFLLCKA--IRNTSTSLHLQLSLCLFLAHLLFLVGIDRTEPKVLCSIIAGALH 427

  Fly   840 CAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVN-----CYYLLSYGLSLSVVAISLVIDPS 899
            ...|:...|...|..|.:.|..:    |.|.....:|     ..:.:.||:....||||....|.
Human   428 YLYLAAFTWMLLEGVHLFLTARN----LTVVNYSSINRLMKWIMFPVGYGVPAVTVAISAASWPH 488

  Fly   900 TYTQNDYCVLMEANALFYATFVIPVLVFFVA-AIGYTFLSWIIMCRKS--RTGLKTKEHTRLASV 961
            .|...|.|.| ..:..|..:|:.||...|.| .:.:..:.||:..:.|  .:.:.|.::||:.:.
Human   489 LYGTADRCWL-HLDQGFMWSFLGPVCAIFSANLVLFILVFWILKRKLSSLNSEVSTIQNTRMLAF 552

  Fly   962 RFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIR 1026
            :...:     |.:|...||.....:..|      |.|..|.|...|:|.|.:||:.:|:.:::::
Human   553 KATAQ-----LFILGCTWCLGLLQVGPA------AQVMAYLFTIINSLQGFFIFLVYCLLSQQVQ 606

  Fly  1027 REYRKYVRQHAWLPKCLRCSKT-SISSGIVTGNGPTAGTLCSVSTSKK 1073
            ::|:|:.|:   :.|....|:| ::||.:...:.|:.|.:......:|
Human   607 KQYQKWFRE---IVKSKSESETYTLSSKMGPDSKPSEGDVFPGQVKRK 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	45/240 (19%)
		GPS	705..752	CDD:197639	18/48 (38%)
		7tm_4	763..1014	CDD:304433	65/258 (25%)
ADGRE3	NP_115960.2	EGF_CA	67..104	CDD:238011	10/48 (21%)
		GPS	304..344	CDD:280071	16/39 (41%)
		7tm_4	353..594	CDD:304433	66/265 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910