Protein Alignment Cirl and FBN3

DIOPT Version :9

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: XP_016882868.1
• Gene: FBN3 / 84467
• HGNCID: 18794
• Length: 2851
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 111/587 - (18%)
• Similarity: 158/587 - (26%)
• Gaps: 200/587 - (34%)

  Fly    25 ACEGKKLTIE----CDPGDVIN--------LIRANYGRFSITICND----------HG---NVEW 64
            ||.|:....|    |..||.::        ..|........|:|.|          :|   |:..
Human  1844 ACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIG 1908

  Fly    65 SVNCM-FPKSLSVLNSRCAHKQSCGVLA------------------------------------- 91
            |.||: ||..:...|..|.....|..|.
Human  1909 SYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTN 1973

  Fly    92 -ATSMFGDPCPGTHKYLEAHYQCI----------------------SAAQTSTTTNRPS------ 127
             ..|:.|...|||.:.||..::||                      :.....|.||.|.
Human  1974 ECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLC 2038

  Fly   128 PPPWVLS-NGPPIFGNGSGLIHPPGVGAGAPPPPRLPTLPGVVGISGNPG-----LFNVPPQHTA 186
            ||.:||| ||...|..................|....|.......|..||     ...:.||
Human  2039 PPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQ--- 2100

  Fly   187 VTHSTPSSSTTAVGGGRLKGGATSTTTTKHPAGRHDGLPPPPQLHHHHNHHGEDTASPTKP---- 247
                              :|.|......  |.| |..:|.|.......|...|:....|..
Human  2101 ------------------EGSAAFQELC--PFG-HGAVPGPDDSREDVNECAENPGVCTNGVCVN 2144

  Fly   248 -----SSKLPAGGNATSPSNTRILTGVGGSGTDDGTLLTTKSSPNRPPGTAASGSVV-------- 299
                 ..:.|.|.:..       .||:....||:       .|...|.|.....:|:
Human  2145 TDGSFRCECPFGYSLD-------FTGINCVDTDE-------CSVGHPCGQGTCTNVIGGFECACA 2195

  Fly   300 ----PGNGSVVRTINNINLN--AAGMSGGDDESKLFCGPTHARNLYWNMTRVGDVNVQPCPGG-- 356
                ||.......|:..:||  .......:.|....|.......|..:.....||:  .|..|
Human  2196 DGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVD--ECADGQQ 2258

  Fly   357 ---AAG------IAKWRCVL---MKRIPDSGYDEYDDDISSTTP-APSGGDCLHNSSS----CEP 404
               |.|      |..:.||.   |:.:|.||....||:.....| ....|.|::.:.|    |:
Human  2259 DCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD- 2322

  Fly   405 PVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLY 469
                        ..|:|     :|.||:|..:........|.|  :...|:::....||.::...
Human  2323 ------------EGFQP-----SPTLTECHDIRQGPCFAEVLQ--TMCRSLSSSSEAVTRAECCC 2368

  Fly   470 GG 471
            ||
Human  2369 GG 2370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	26/143 (18%)
		GAIN	453..680	CDD:293098	5/19 (26%)
		GPS	705..752	CDD:197639
		7tm_4	763..1014	CDD:304433
FBN3	XP_016882868.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910