Protein Alignment Cirl and ADGRA1

DIOPT Version :10

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: NP_001077378.1
• Gene: ADGRA1 / 84435
• HGNCID: 13838
• Length: 560
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 126/602 - (20%)
• Similarity: 201/602 - (33%)
• Gaps: 154/602 - (25%)

  Fly   769 FIYISIGICVVFIVIALL---TLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLL---GIEQTET 827
            |::..:..|...:::.||   ...:.:...::.:|...:|.:..|..| .|.|.:   ||.:|:.
Human    16 FLHPVVYACTAVMLLCLLASFVTYIVHQSAIRISRKGRHTLLNFCFHA-ALTFTVFAGGINRTKY 79

  Fly   828 SIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSD-ELLLEVDQTP----KVNCYYLLSYGLSL 887
            .|.|..:.|.||.:.||...|....|.:.|..:|.. .|.|:.||.|    .:..:||:|.|:..
Human    80 PILCQAVGIVLHYSTLSTMLWIGVTARNIYKQVTKKAPLCLDTDQPPYPRQPLLRFYLVSGGVPF 144

  Fly   888 SVVAISLVIDPSTYTQND----YCVLMEANAL--FYATFVIPVLVFFVAAIGYTFLSWIIMCRK- 945
            .:..::...:...|...|    ||.:....:|  ||....|..||..|     .||...:..|:
Human   145 IICGVTAATNIRNYGTEDEDTAYCWMAWEPSLGAFYGPAAIITLVTCV-----YFLGTYVQLRRH 204

  Fly   946 --SRTGLKT--KEHTRLA----------------------------SVRFDIRCSFVFLLLLSAV 978
              .|..|:|  :|..|||                            |.:..:|.:...|.|.:|.
Human   205 PGRRYELRTQPEEQRRLATPEGGRGIRPGTPPAHDAPGASVLQNEHSFQAQLRAAAFTLFLFTAT 269

  Fly   979 WC-SAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKC 1042
            |. .|....:|..:|...:.:||    .|...|||::.:.||.:.|.:            |....
Human   270 WAFGALAVSQGHFLDMVFSCLYG----AFCVTLGLFVLIHHCAKREDV------------WQCWW 318

  Fly  1043 LRCSKTSISSGIVTGNGPTAGTLCSVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGAT 1107
            ..|.....:...:..||...|....:.:   |.|         ..|:.....|.|
Human   319 ACCPPRKDAHPALDANGAALGRAACLHS---PGL---------GQPRGFAHPPGP---------- 361

  Fly  1108 SDCELNEAQQRRTLKSGLMTGTLQAPPQTLGGHV-VLERGSTLRSTGHASP-TSSAGSTHLIFAH 1170
              |::...|..:                   ||. .|...:...:..|..| |:.....||
Human   362 --CKMTNLQAAQ-------------------GHASCLSPATPCCAKMHCEPLTADEAHVHL---- 401

  Fly  1171 KQQQQQQQQGPLGESYYHQPDYYSWKQPSTGTGGLKTPREYYNNAGAAASSPQQAHEVFYWTQKP 1235
                  |::|..|    |.|..:...|     |..|.|  |::.  ..|..|:.|:.:      |
Human   402 ------QEEGAFG----HDPHLHGCLQ-----GRTKPP--YFSR--HPAEEPEYAYHI------P 441

  Fly  1236 NSGHNGKKKRGAGGVPASPSGSLHSRT-AAASQVLFYPSYKKTKPGQPTGYPQYAEALDPPLATG 1299
            :|.....:.......|:|..|...:.| |..:|...:|..  |:|....|.|.....   |...|
Human   442 SSLDGSPRSSRTDSPPSSLDGPAGTHTLACCTQGDPFPMV--TQPEGSDGSPALYSC---PTQPG 501

  Fly  1300 NAAAYYQ-QQQQLRRQQ 1315
            ..||... ..:.|||.|
Human   502 REAALGPGHLEMLRRTQ 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Rha_Lectin_dCirl	22..113	CDD:438687
		GAIN	451..682	CDD:465137
		GPS	705..752	CDD:197639
		7tmB2_CELSR_Adhesion_IV	763..1035	CDD:320557	72/316 (23%)
		TM helix 1	765..790	CDD:320557	4/23 (17%)
		TM helix 2	801..823	CDD:320557	6/24 (25%)
		TM helix 3	832..859	CDD:320557	8/26 (31%)
		TM helix 4	875..895	CDD:320557	4/19 (21%)
		TM helix 5	913..942	CDD:320557	9/30 (30%)
		TM helix 6	960..987	CDD:320557	7/27 (26%)
		TM helix 7	997..1022	CDD:320557	8/24 (33%)
		Herpes_TAF50	<1219..1365	CDD:308764	24/99 (24%)
ADGRA1	NP_001077378.1	7tm_GPCRs	14..323	CDD:475119	74/328 (23%)
		TM helix 1	17..41	CDD:410628	3/23 (13%)
		TM helix 2	53..74	CDD:410628	5/21 (24%)
		TM helix 3	84..106	CDD:410628	6/21 (29%)
		TM helix 4	134..150	CDD:410628	4/15 (27%)
		TM helix 5	172..195	CDD:410628	7/27 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..242		6/31 (19%)
		TM helix 6	256..278	CDD:410628	6/21 (29%)
		TM helix 7	285..310	CDD:410628	8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	438..473		7/40 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..560