DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and adgrg4a

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_021336868.1	Gene:	adgrg4a / 793963	ZFINID:	ZDB-GENE-121129-2	Length:	1201	Species:	Danio rerio

Alignment Length:	780	Identity:	172/780 - (22%)
Similarity:	290/780 - (37%)	Gaps:	226/780 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 GAAGIAKW------RCVLMKRIPDSGYDEYDDDISSTTPAPSGG----DCLHNSSSCEPPVSMAH 410
            ||...|.|      :|  :|.:.|.|      |:.:.|..|...    |.:.:..:.:..:|.|
Zfish   563 GATDKAIWEAPDMSKC--LKTVSDFG------DLENITVTPGNSEYIVDMIEDLLNEQTGLSNA- 618

  Fly   411 KVNQRLRNFEPTWH--PATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDM 473
            :::..|........  ..||||:                  ||:.:|.:::..:|::.|
Zfish   619 QLDIMLEKLSEVTEVGTLTPDLS------------------SSITNIVSEICHITTNLT------ 659

  Fly   474 LVTTKIIQTVSEKMMHDKETFP-DQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMR 537
            .||.||:....  :|.|:..|. |.....|..:.|               ||     :||:
Zfish   660 QVTNKILSITD--LMGDRTVFAGDAHNMTAPSLAL---------------QL-----INPD---- 698

  Fly   538 VATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSS---VVFPDSDQWPLSSD 599
              ||...||.:                             |..::|:.   .:|.|.:
Zfish   699 --TSQFHGLTF-----------------------------EVSSVQNDGTPEIFYDEN------- 725

  Fly   600 RIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKS-SRSYVR----NTAILSNDSDV 659
                    ..:|.:.|.|..:         .|.|:.::|...| :|..|:    ....|..|:..
Zfish   726 --------FTENPDTGTVAFI---------SLPPTIENFFPNSGARPRVQFHFYGKEKLFEDTSS 773

  Fly   660 NAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLKT-ENVTNPTCVFWNYIDH----AW 719
            |.        .|||.|:|||:......:|..|:.:||:||:. |:.....||:|::..:    .|
Zfish   774 NL--------TLNSYVVSASVTNATVSELEIPVMVTLRHLQNKEDWDIVKCVYWDFNKNDKKGGW 830

  Fly   720 SANGCSLESTNRTHSVCSCNHLTNFAILMDV----VDEHQHSLFTMFDGNMRIFIYISIGICVVF 780
            :..||.:.::|.|.:.|||:|||:|.:|:|:    ::.....:.|       |..|:..||..:|
Zfish   831 NDRGCEIVNSNATQTSCSCDHLTHFGVLLDISKTPINPKDEWVLT-------IISYVGCGISSIF 888

  Fly   781 IVIALLTLKLFNGVFVKSAR---TSIYTSIYLCLLAIELLFLLG--IEQTETSIFCGFITIFLHC 840
            :.:.|||...|.    |..|   :.|..::.:.||.:.:|||:.  .....::..|..:..|.|.
Zfish   889 LGVTLLTYLAFE----KLRRDYPSKILINLCMALLGLNMLFLVNSWFASFNSNALCITVAAFQHY 949

  Fly   841 AILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKV-NCY---YLLSY-----GLSLSVVAISLVI 896
            ..|:...|....|.:.|..|.            || |.|   |:|.:     |:.||||.:.|.|
Zfish   950 FFLATFTWMGLGAINMYLALV------------KVFNSYVPSYILKFCAVGWGIPLSVVILVLAI 1002

  Fly   897 DPSTY-TQNDYCVLMEANAL--------FYATFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKT 952
            |.::| |.....:|.|:.|.        ||.|.|...::..|..| ..|:..::...|.|.   .
Zfish  1003 DFNSYGTSLSTDLLQESTAFCWFKNDVTFYVTVVSFAILIMVCNI-IVFVVVLVQIHKMRV---N 1063

  Fly   953 KEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVF 1017
            |..:.......|:|.......||...|...:|....||..      ..|.|...|:|.|.:||:|
Zfish  1064 KPSSSRKGFLHDLRVVASLTFLLGLTWILVFFGWGPAKTP------LMYLFSILNSLQGFFIFLF 1122

  Fly  1018 HCIQNEKIRREYRKYVRQHAWLPKCLRCSK------TSISSGIVTGNGPTAGTLCSVSTSKKPKL 1076
            :|:..:.:|:::|.:          |.|.:      :..|..:..|:....|  ..||:|.|.::
Zfish  1123 YCLMKDNVRKQWRMH----------LCCGRFRESEYSDWSRSVPKGDKGKGG--LQVSSSMKSEI 1175

Fly 1077 1076
Zfish 1176 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	43/235 (18%)
		GPS	705..752	CDD:197639	17/54 (31%)
		7tm_4	763..1014	CDD:304433	67/273 (25%)
adgrg4a	XP_021336868.1	LamG	50..210	CDD:328935
		HsdR	<637..>729	CDD:333053	31/187 (17%)
		GPS	815..858	CDD:307782	15/42 (36%)
		7tmB2_GPR112	871..1138	CDD:320663	74/309 (24%)
		TM helix 1	873..898	CDD:320663	9/31 (29%)
		TM helix 2	908..930	CDD:320663	6/21 (29%)
		TM helix 3	941..968	CDD:320663	6/26 (23%)
		TM helix 4	983..999	CDD:320663	5/15 (33%)
		TM helix 5	1028..1051	CDD:320663	6/23 (26%)
		TM helix 6	1073..1098	CDD:320663	6/24 (25%)
		TM helix 7	1102..1127	CDD:320663	9/30 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910