Protein Alignment Cirl and Adgrl1

DIOPT Version :9

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: XP_038953892.1
• Gene: Adgrl1 / 65096
• RGDID: 620768
• Length: 1516
• Species: Rattus norvegicus
• Alignment Length: 1581
• Identity: 375/1581 - (23%)
• Similarity: 595/1581 - (37%)
• Gaps: 410/1581 - (25%)

  Fly    25 ACEGKKLTIECDPGDVINLIRANYGRFSITICN-DHGNVEWSVNCMFPKSLSVLNSRCAHKQSCG 88
            ||||..:.:.|...|||.:..|||||....||: |...:| :|.|..|.:..:::.||.::..|.
  Rat    40 ACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQME-NVQCYLPDAFKIMSQRCNNRTQCV 103

  Fly    89 VLAATSMFGDPCPGTHKYLEAHYQCIS-------------------------------------- 115
            |:|.:..|.||||||:||||..|.|:.
  Rat   104 VVAGSDAFPDPCPGTYKYLEVQYDCVPYKVEQKVFVCPGTLQKVLEPTSTHESEHQSGAWCKDPL 168

  Fly   116 -----------------------------AAQTSTT---TNRPSPPPWVLSNGPPIFG------- 141
                                         ||:.:||   .||.....:|:.:|...:.
  Rat   169 QAGDRIYVMPWIPYRTDTLTEYASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNI 233

  Fly   142 ----------NGSGLIHPPGVGAGAP-------------PPPRLPTLPGVVGISG-------NPG 176
                      :|..:|:.......:|             ....|..:....|.:|       ||
  Rat   234 VKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEGNNGRLVVSQLNP- 297

  Fly   177 LFNVPPQHTAVTHSTPSSSTTA--------------------VGGGRLKGGATSTTTTKHPAGRH 221
             :.:..:.|..|.....|::.|                    ..|.|:.....:....:.|...
  Rat   298 -YTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSL- 360

  Fly   222 DGLPPPPQLHHHHNHHGEDTA----------------SPTKPSSKLPAGGNATSP----SNTRIL 266
             ..|.|.|.....:::..|..                .|..||:     |.||||    :.|...
  Rat   361 -AFPNPYQFVSSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSA-----GPATSPPLSTTTTARP 419

  Fly   267 TGVGGSGTDDGTL------LTT-------KSSPNRPPGTAASGSVVPGNGSVVRTINNINLNAAG 318
            |.:..:.:...|.      |||       :..|:.||.||.:.|        .|.....||:.:
  Rat   420 TPLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPAPS--------TRRPPAPNLHVS- 475

  Fly   319 MSGGDDESKLFCGPTHARNLYWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDI 383
                   .:|||.|...|.:.|..|:.|.:..:|||.|..|||.::|:
  Rat   476 -------PELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCL----------------- 516

  Fly   384 SSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQR 448
                  |:.|                            .|:|..|||:.|.|.|:|.:..::...
  Rat   517 ------PALG----------------------------LWNPRGPDLSNCTSPWVNQVAQKIKSG 547

  Fly   449 DSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETF-PDQRQ-----------RE 501
            ::: .:||::::..|.. ::|.||:..:.|:::.:.:.:....:.. |.:|:           ||
  Rat   548 ENA-ANIASELARHTRG-SIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRE 610

  Fly   502 AMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQK 566
            ....:.:..||:|..|||....|.||.|:|..:|:..||.||..||..||||||.:......:..
  Rat   611 RTCKDYIKAVVETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEEGAFLLADNVREPARFLAA 675

  Fly   567 VKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESIL 631
            .:|::|.|.||.|:.....:|||   |...|...|:|....:..||..|:|::||..::.|...|
  Rat   676 KQNVVLEVTVLSTEGQVQELVFP---QEYASESSIQLSANTIKQNSRNGVVKVVFILYNNLGLFL 737

  Fly   632 KPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGK-GRHIQLSQPITLT 695
            .               ...|.:....:...|.......::||:||:||:.| ...:.|..|:..|
  Rat   738 S---------------TENATVKLAGEAGTGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFT 787

  Fly   696 LKHLKTENVTNPTCVFWNYIDHA----WSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQH 756
            :.||:.:|..|..|.||||.:.:    ||..||.|..:|:||:.|:|:||||||:||...:.:|.
  Rat   788 VAHLEAKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNFAVLMAHREIYQG 852

  Fly   757 SLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLG 821
            .:..:.   :.:..::.|.|.:|.:.|.:.|.....|  :::.|.:|:.::.:.|...|||||:|
  Rat   853 RINELL---LSVITWVGIVISLVCLAICISTFCFLRG--LQTDRNTIHKNLCINLFLAELLFLVG 912

  Fly   822 IEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEV--DQTPKVNCYYLLSYG 884
            |::|:..:.|......||...|:..:|.|.|..|.|.      ||:||  .:..:...|||..|.
  Rat   913 IDKTQYEVACPIFAGLLHYFFLAAFSWLCLEGVHLYL------LLVEVFESEYSRTKYYYLGGYC 971

  Fly   885 LSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWII--MCRKSR 947
            ....||.|:..||..:|.....|.|...| .|..:|:.|  |.||..:...||...:  |.|.|.
  Rat   972 FPALVVGIAAAIDYRSYGTEKACWLRVDN-YFIWSFIGP--VSFVIVVNLVFLMVTLHKMIRSSS 1033

  Fly   948 TGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGL 1012
            . || .:.:||.:::.....:...|.||...|.....::....:      |..|.|..||...|:
  Rat  1034 V-LK-PDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESV------VMAYLFTTFNAFQGV 1090

  Fly  1013 YIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRC---------------SKTSISSGI-VTGNGPT 1061
            :||||||...:|:.:||.|.:| |::.  |:|.               |.|...:|. |.|.|..
  Rat  1091 FIFVFHCALQKKVHKEYSKCLR-HSYC--CIRSPPGGAHGSLKTSAMRSNTRYYTGTQVPGQGRH 1152

  Fly  1062 AGTLCSVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGATSDCEL----NEAQQRRTLK 1122
            ...: |:....:..||     |:..||..|.....|:|    .|......:    |:..:::| :
  Rat  1153 IHQV-SLGPRGRSALP-----ESQKDPGGQSGPGDPLT----FGLCPQSRIRRMWNDTVRKQT-E 1206

  Fly  1123 SGLMTGTLQAPPQ----TLGGHVVLERGSTLRSTGHASP-----TSSAG---STHLIFAHKQQQQ 1175
            |..|.|.:.:.|.    |:|.|::  ....|:..|..||     ..|.|   |:..:| :.....
  Rat  1207 SSFMAGDINSTPTLNRGTMGNHLL--TNPVLQPRGGTSPYNTLIAESVGFNPSSPPVF-NSPGSY 1268

  Fly  1176 QQQQGPLG-----------------ESY-YHQPDYYSWKQPSTGTGGLKTPREYYNNAGAAASSP 1222
            ::.:.|||                 .|| ....|:      ..|.||.:.||. .|.|.|||...
  Rat  1269 REPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDF------PPGDGGPEPPRG-RNLADAAAFEK 1326

  Fly  1223 QQAHEVFYWTQKPNSGHNGKKKRGAGGVPASPSGSLHSRTAAASQVLFYPSYKKTKPGQPTGYPQ 1287
            ....|:.:...:..||       ||.|.|..|            .|...|...:.:.|.|.|..:
  Rat  1327 MIISELVHNNLRGASG-------GAKGPPPEP------------PVPPVPGVSEDEAGGPGGADR 1372

  Fly  1288 YAE------ALDPPLATGNAAAYYQQQQQLRRQQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQ- 1345
             ||      ||:.||....|.:.. .|..|...:....:.....:.|||...:...:|...:|:
  Rat  1373 -AEIELLYKALEEPLLLPRAQSVL-YQSDLDESESCTAEDGATSRPLSSPPGRDSLYASGANLRD 1435

  Fly  1346 -------RRAGSQQQLPAPPP 1359
                   ...|..:.||.|||
  Rat  1436 SPSYPDSSPEGPNEALPPPPP 1456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	33/80 (41%)
		GAIN	453..680	CDD:293098	63/238 (26%)
		GPS	705..752	CDD:197639	24/50 (48%)
		7tm_4	763..1014	CDD:304433	68/254 (27%)
Adgrl1	XP_038953892.1	Gal_Lectin	48..128	CDD:396628	33/80 (41%)
		OLF	142..398	CDD:413369	27/259 (10%)
		PHA03247	<398..482	CDD:223021	26/104 (25%)
		HormR	476..539	CDD:214468	26/113 (23%)
		GAIN	549..773	CDD:406802	64/243 (26%)
		GPS	797..849	CDD:197639	24/51 (47%)
		7tmB2_Latrophilin-1	856..1113	CDD:320673	79/279 (28%)
		TM helix 1	859..883	CDD:320673	5/23 (22%)
		TM helix 2	892..913	CDD:320673	7/20 (35%)
		TM helix 3	923..945	CDD:320673	6/21 (29%)
		TM helix 4	964..980	CDD:320673	6/15 (40%)
		TM helix 5	999..1022	CDD:320673	8/25 (32%)
		TM helix 6	1049..1071	CDD:320673	4/21 (19%)
		TM helix 7	1075..1100	CDD:320673	12/30 (40%)
		Latrophilin	1112..1516	CDD:396778	86/390 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8556
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2154
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000766
OrthoInspector	1	1.000	-	-		otm45134
orthoMCL	1	0.900	-	-		OOG6_102405
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X858
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.960