DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cirl and ADGRL4

DIOPT Version :9

Sequence 1:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster
Sequence 2:NP_071442.2 Gene:ADGRL4 / 64123 HGNCID:20822 Length:690 Species:Homo sapiens


Alignment Length:690 Identity:158/690 - (22%)
Similarity:274/690 - (39%) Gaps:141/690 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   392 GGDCLHN-SSSCE-PPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLE----------MR 444
            |..|:.| :::|. ..|.:|..:|:.|........|    :...:.::.|::.          :.
Human   104 GTVCIENVNANCHLDNVCIAANINKTLTKIRSIKEP----VALLQEVYRNSVTDLSPTDIITYIE 164

  Fly   445 VNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQ---RQREAMIME 506
            :....|||:...|  :.:::..||....:   |:.::||:..:..|.....|:   ..|...:.:
Human   165 ILAESSSLLGYKN--NTISAKDTLSNSTL---TEFVKTVNNFVQRDTFVVWDKLSVNHRRTHLTK 224

  Fly   507 LLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNIL 571
            |:|.|.:....:....|.::..|.|..|                                     
Human   225 LMHTVEQATLRISQSFQKTTEFDTNSTD------------------------------------- 252

  Fly   572 LSVRVLETKTIQSSVVFPDSDQWPLSSDRIEL--PRAALIDNSEGGLVRIVFAAFDRLESILKPS 634
            ::::|....:.....:.|..:   :..|.|.:  .|.|..|::  |.|.:.|..:..:..:|..|
Human   253 IALKVFFFDSYNMKHIHPHMN---MDGDYINIFPKRKAAYDSN--GNVAVAFVYYKSIGPLLSSS 312

  Fly   635 YDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQP-------- 691
             |:|.||..                |....::..|:::| |||.|:.       |.|        
Human   313 -DNFLLKPQ----------------NYDNSEEEERVISS-VISVSMS-------SNPPTLYELEK 352

  Fly   692 ITLTLKHLKTENVTNPTCVFWNY----IDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMD--- 749
            ||.||.|.|..:.....|.||||    ::.:||:.||.|..:|.||:.|.|||||:|||||.   
Human   353 ITFTLSHRKVTDRYRSLCAFWNYSPDTMNGSWSSEGCELTYSNETHTSCRCNHLTHFAILMSSGP 417

  Fly   750 VVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAI 814
            .:....:::.|..   .::.|.||: ||   :.|.:.|...|:.  ::|.||:|:.::...|...
Human   418 SIGIKDYNILTRI---TQLGIIISL-IC---LAICIFTFWFFSE--IQSTRTTIHKNLCCSLFLA 473

  Fly   815 ELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTS---DELLLEVDQTPKVN 876
            ||:||:||......:||..|...||...|:..||.|.|..|.|..:..   ::..|..:      
Human   474 ELVFLVGINTNTNKLFCSIIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKN------ 532

  Fly   877 CYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPV-LVFFVAAIGYTFLSWI 940
             :|:..|.....||..|..:....|.....|.|...|. |..:|:.|. |:..|..:.:..:.:.
Human   533 -FYIFGYLSPAVVVGFSAALGYRYYGTTKVCWLSTENN-FIWSFIGPACLIILVNLLAFGVIIYK 595

  Fly   941 IMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFIC 1005
            :.  :...||| .|.:...::|...|.:...|.||...|.....::..|.:      |..|.|..
Human   596 VF--RHTAGLK-PEVSCFENIRSCARGALALLFLLGTTWIFGVLHVVHASV------VTAYLFTV 651

  Fly  1006 FNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRC 1045
            .|...|::||:|.|:.:.||:.||.:..:.   :|.|..|
Human   652 SNAFQGMFIFLFLCVLSRKIQEEYYRLFKN---VPCCFGC 688

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CirlNP_001260807.1 Gal_Lectin 33..113 CDD:280328
GAIN 453..680 CDD:293098 38/231 (16%)
GPS 705..752 CDD:197639 24/53 (45%)
7tm_4 763..1014 CDD:304433 62/254 (24%)
ADGRL4NP_071442.2 EGF_CA 58..>91 CDD:284955
GAIN 139..330 CDD:293098 38/258 (15%)
GPS 368..412 CDD:280071 21/43 (49%)
7tm_4 424..660 CDD:304433 63/261 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 61 1.000 Domainoid score I10457
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000766
OrthoInspector 1 1.000 - - otm40998
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR12011
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.910

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