DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and EVA1C

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_478067.2	Gene:	EVA1C / 59271	HGNCID:	13239	Length:	441	Species:	Homo sapiens

Alignment Length:	153	Identity:	41/153 - (26%)
Similarity:	59/153 - (38%)	Gaps:	32/153 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CEGKKLTIECDPGDVINLIRANYGRFS--ITICNDHGNVEWSVNCMFPKSLSVLNSRCAHKQSCG 88
            ||.::|.:.|.....:|:..|.|||.:  ..||:.........:|:...:|.||:.||..||.|.
Human   169 CEDQELKLHCHESKFLNIYSATYGRRTQERDICSSKAERLPPFDCLSYSALQVLSRRCYGKQRCK 233

  Fly    89 VLAATSMFGDPC-PGTHKYLEAHYQCISAAQTSTTTNRPSPPPWVLSNGPPIFGNGSGLIHPPGV 152
            ::.....||.|| ||..|||...|.|:              |..:|:...|...|
Human   234 IIVNNHHFGSPCLPGVKKYLTVTYACV--------------PKNILTAIDPAIAN---------- 274

  Fly   153 GAGAPPPPRLPTLPGVVGISGNP 175
                 ..|.|....|..||:.:|
Human   275 -----LKPSLKQKDGEYGINFDP 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	27/82 (33%)
		GAIN	453..680	CDD:293098
		GPS	705..752	CDD:197639
		7tm_4	763..1014	CDD:304433
EVA1C	NP_478067.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Gal_Lectin	75..158	CDD:280328
		Gal_Lectin	176..259	CDD:280328	27/82 (33%)
		FAM176	301..441	CDD:291517
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..390
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4729
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810