DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and ADGRB3

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_001695.2	Gene:	ADGRB3 / 577	HGNCID:	945	Length:	1522	Species:	Homo sapiens

Alignment Length:	1039	Identity:	217/1039 - (20%)
Similarity:	360/1039 - (34%)	Gaps:	303/1039 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 GTAASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARNLYWNMTRVGDVNVQPCPG 355
            |...:|....|.|..||..|.....|         ....|...:..::.|..|..||:....||.
Human   484 GAVITGQQCEGTGEEVRRCNEQRCPA---------PYEICPEDYLMSMVWKRTPAGDLAFNQCPL 539

  Fly   356 GAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNFE 420
            .|.|....||.|                           .||..:..|.| |.|..::...|:.:
Human   540 NATGTTSRRCSL---------------------------SLHGVAFWEQP-SFARCISNEYRHLQ 576

  Fly   421 PTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSE 485
               |.....|.:.:.:...:          .:..:...:.::|..|..|.||:|::.:|::.|:
Human   577 ---HSIKEHLAKGQRMLAGD----------GMSQVTKTLLDLTQRKNFYAGDLLMSVEILRNVT- 627

  Fly   486 KMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRV---ATSLLTGLE 547
                  :||  :|.......:.:....:..||||||.....|     ||..::   :..|:..:|
Human   628 ------DTF--KRASYIPASDGVQNFFQIVSNLLDEENKEKW-----EDAQQIYPGSIELMQVIE 679

  Fly   548 -------------YNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQ-----W 594
                         .|::|:..             |::.|::.|...::.:.:.||...:     |
Human   680 DFIHIVGMGMMDFQNSYLMTG-------------NVVASIQKLPAASVLTDINFPMKGRKGMVDW 731

  Fly   595 PLSS-DRIELPRAAL-------IDNSEGGLVRIVFAAFDRLESILKPSYDHFD--LKSSRSYVRN 649
            ..:| ||:.:|::..       :|.|.      ||.    |.::|   |.:.|  |.:.|:|.
Human   732 ARNSEDRVVIPKSIFTPVSSKELDESS------VFV----LGAVL---YKNLDLILPTLRNYT-- 781

  Fly   650 TAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPIT------LTLKHLKTENVTNPT 708
                                ::|||:|..::       ..:|.|      :.|.|| .....||.
Human   782 --------------------VINSKIIVVTI-------RPEPKTTDSFLEIELAHL-ANGTLNPY 818

  Fly   709 CVFW-----NYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRI 768
            ||.|     |.....||..||....|:.:|:.|.|:.|:.||||.    :....:.....|...:
Human   819 CVLWDDSKTNESLGTWSTQGCKTVLTDASHTKCLCDRLSTFAILA----QQPREIIMESSGTPSV 879

  Fly   769 FIYISIGI-CVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCG 832
            .:.:..|: |:..|.:|::...|:.  :::|.|:.|..:..|.:::..:|.|:|..||.....|.
Human   880 TLIVGSGLSCLALITLAVVYAALWR--YIRSERSIILINFCLSIISSNILILVGQTQTHNKSICT 942

  Fly   833 FITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNC------YYLLSYGLSLSVVA 891
            ..|.|||...|:...|...||:.||..:|.           |:..      :..|.:||...|||
Human   943 TTTAFLHFFFLASFCWVLTEAWQSYMAVTG-----------KIRTRLIRKRFLCLGWGLPALVVA 996

  Fly   892 ISLVIDPST-YTQNDYCVLMEANALFYA-----------TFVIPVLVF--FVAAIGYTFLSWIIM 942
            .|:....:. |..:.||.|.....|.||           ..||.:|||  .|:..|       |:
Human   997 TSVGFTRTKGYGTDHYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSRDG-------IL 1054

  Fly   943 CR--KSRTGLKTKEHTRLASVRFDIRC-------------------------SFVFLLLLSAVWC 980
            .:  |.|.|..::.|:.|.     ::|                         |.|.|.||:..|.
Human  1055 DKKLKHRAGQMSEPHSGLT-----LKCAKCGVVSTTALSATTASNAMASLWSSCVVLPLLALTWM 1114

  Fly   981 SAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRC 1045
            ||..     .|.|..:.::...|..|::|.|..|.:.|||...:::..:|..:|      .|...
Human  1115 SAVL-----AMTDKRSILFQILFAVFDSLQGFVIVMVHCILRREVQDAFRCRLR------NCQDP 1168

  Fly  1046 SKTSISSGIVTGNGPTAGTLCSVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGATSDC 1110
            .....||....|:       ..:.|..:..:.:......|.|..       |.....|.|..|..
Human  1169 INADSSSSFPNGH-------AQIMTDFEKDVDIACRSVLHKDIG-------PCRAATITGTLSRI 1219

  Fly  1111 ELNEAQQRR-TLKSGLMTGTLQAP-------PQTLGGHVVL-----------ERGSTLRSTGHAS 1156
            .||:.::.: |...||...||...       .|..|.|:.:           :..|.||.|.:..
Human  1220 SLNDDEEEKGTNPEGLSYSTLPGNVISKVIIQQPTGLHMPMSMNELSNPCLKKENSELRRTVYLC 1284

  Fly  1157 PTSSAGSTHLIFAHKQQQQQQQQGPLGESYY---------HQPDYYSWKQPSTGTGGLKT-PRE 1210
            ...:.....:...|.|::..       ||.|         :||   |.|:.|....|::| |.|
Human  1285 TDDNLRGADMDIVHPQERMM-------ESDYIVMPRSSVNNQP---SMKEESKMNIGMETLPHE 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	49/257 (19%)
		GPS	705..752	CDD:197639	19/51 (37%)
		7tm_4	763..1014	CDD:304433	70/298 (23%)
ADGRB3	NP_001695.2	RSN1_7TM	98..>175	CDD:330792
		TSP1	296..343	CDD:214559
		TSP1	348..398	CDD:214559
		TSP1	403..452	CDD:214559
		TSP1	458..508	CDD:214559	7/23 (30%)
		HormR	510..576	CDD:214468	19/93 (20%)
		GAIN	594..794	CDD:318649	49/268 (18%)
		GPS	816..867	CDD:197639	19/54 (35%)
		7tmB2_BAI3	872..1164	CDD:320655	76/327 (23%)
		TM helix 1	876..901	CDD:320655	4/24 (17%)
		TM helix 2	911..933	CDD:320655	5/21 (24%)
		TM helix 3	942..970	CDD:320655	10/27 (37%)
		TM helix 4	980..1000	CDD:320655	7/19 (37%)
		TM helix 5	1018..1047	CDD:320655	8/28 (29%)
		TM helix 6	1094..1121	CDD:320655	8/31 (26%)
		TM helix 7	1126..1151	CDD:320655	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010