Protein Alignment Cirl and ADGRB2

DIOPT Version :10

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: NP_001351786.1
• Gene: ADGRB2 / 576
• HGNCID: 944
• Length: 1585
• Species: Homo sapiens
• Alignment Length: 1570
• Identity: 328/1570 - (20%)
• Similarity: 509/1570 - (32%)
• Gaps: 464/1570 - (29%)

  Fly    30 KLTIECDPGDVINLI--RANYGRF-SITICNDHGNVEWSVNCMFPKSLSVLNSRCAHKQSCGVLA 91
            :|.:..:|.:...|:  .|...|| .:.:.|::.:.:::...:           |...:.||..|
Human   159 QLCLSAEPSEAPRLLAPAALAFRFVEVLLINNNNSSQFTCGVL-----------CRWSEECGRAA 212

  Fly    92 ATSM-FGDP---CPGTHKYLEAHYQCISAAQTSTTTNRPSPP-PWVLSN-------GPP----IF 140
            ..:. |..|   |||            .|...||||..|.|| ...|||       .||    :.
Human   213 GRACGFAQPGCSCPG------------EAGAGSTTTTSPGPPAAHTLSNALVPGGPAPPAEADLH 265

  Fly   141 GNGSGLIHPPGVGAGAPPP---------PRLPTLPGV-VGISGNPGLFNVPP------------- 182
            ...|..:....:..|..|.         ||....||: :..:|:|......|
Human   266 SGSSNDLFTTEMRYGEEPEEEPKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQ 330

  Fly   183 QHTAVTHSTP----------------SSSTTAVGGGRLKGGATSTTTTKHPAGRHDGLPP--PPQ 229
            ..|....|:|                :|:|..|.|...:.|:.|..:.....|....:..  |||
Human   331 VRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQ 395

  Fly   230 LHHHHNHHGEDTASPTKPSSKL----------------PAGGNATSPSNTRILTGVGGSGTDDGT 278
                   ||.......:..:||                |.|..:||.:|          ||..
Human   396 -------HGGKACEGPELQTKLCSMAACPVEGQWLEWGPWGPCSTSCAN----------GTQQ-- 441

  Fly   279 LLTTKSSPNRPPGTAASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARNLYW--- 340
             .:.|.|...|.....:|::..     .|..:|:...|.....|...:...|..|  .:..|
Human   442 -RSRKCSVAGPAWATCTGALTD-----TRECSNLECPATDSKWGPWNAWSLCSKT--CDTGWQRR 498

  Fly   341 -NMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIP---DSGYDEYDDDISSTTPAPSGGDCLHNSSS 401
             .|.:.......||.|....:   :....||.|   :...|||  .:..|....:.|:.::|  .
Human   499 FRMCQATGTQGYPCEGTGEEV---KPCSEKRCPAFHEMCRDEY--VMLMTWKKAAAGEIIYN--K 556

  Fly   402 CEPPVSMAHKVNQRLRNFEPTWHPATPDLTQC-----RSLWLNNLE-MRVNQR---DSSLISIAN 457
            | ||.:......:.|.:.:...:...|...:|     |.|:|:..| :...||   ...:..:..
Human   557 C-PPNASGSASRRCLLSAQGVAYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVR 620

  Fly   458 DMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETF---PDQRQREAMIMELLHCVVKTGSNLL 519
            .:.|:.:.:|.|.||:|.:..|::.|::..  .:.|:   .|..||...::          |.::
Human   621 SLQELLARRTYYSGDLLFSVDILRNVTDTF--KRATYVPSADDVQRFFQVV----------SFMV 673

  Fly   520 DESQLSSWLDLNPEDQMRV---ATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKT 581
            |......|     :|..:|   :..||..:|....|:.|.:...:|.:....|:::|::......
Human   674 DAENKEKW-----DDAQQVSPGSVHLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPVSA 733

  Fly   582 IQSSVVFP-----DSDQWPL-SSDRIELPRAALIDNSEGGLVRIVFAAF---DRLESILKPSYDH 637
            :.|.:.||     ....|.. |.||:.||:..|..:|.|.......|..   .|....:.|...|
Human   734 VSSDITFPMRGRRGMKDWVRHSEDRLFLPKEVLSLSSPGKPATSGAAGSPGRGRGPGTVPPGPGH 798

  Fly   638 FDLKSSRSYVRNTAILSNDSDVNA----GEIQQRL-----------RILNSKVISASLGKGRHIQ 687
                   |:.|   :|..|.|.::    |.:..|.           ..:.|:|::.::.......
Human   799 -------SHQR---LLPADPDESSYFVIGAVLYRTLGLILPPPRPPLAVTSRVMTVTVRPPTQPP 853

  Fly   688 LSQPITLTLKHLKTENVTNPTCVFWNY--IDHA---WSANGCSLESTNRTHSVCSCNHLTNFAIL 747
            ....||:.|.:: ....|:|.|..|:|  .|.:   |....|....|...|:.|.|.||:.||:|
Human   854 AEPLITVELSYI-INGTTDPHCASWDYSRADASSGDWDTENCQTLETQAAHTRCQCQHLSTFAVL 917

  Fly   748 MDVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGV---FVKSARTSIYTSIYL 809
            .    :....|.....|:..:.:.|.   |.| ..:|||||......   |:||.|:.|..:..|
Human   918 A----QPPKDLTLELAGSPSVPLVIG---CAV-SCMALLTLLAIYAAFWRFIKSERSIILLNFCL 974

  Fly   810 CLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPK 874
            .:||..:|.|:|..:..:...|.....|||...||...|...||:.||..:....      :|..
Human   975 SILASNILILVGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRM------RTRL 1033

  Fly   875 VNCYYL-LSYGLSLSVVAISLVIDPST-YTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFL 937
            |...:| |.:||...|||:|:....:. |..:.||.|.....|.|| ||.|..|..:.    ..|
Human  1034 VRKRFLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYA-FVGPAAVIVLV----NML 1093

  Fly   938 SWIIMCRK--SRTGLKTKEHTRLASVRFDIRC--------------------------------- 967
            ..||:..|  :|.|:..|...:.|...   ||
Human  1094 IGIIVFNKLMARDGISDKSKKQRAGSE---RCPWASLLLPCSACGAVPSPLLSSASARNAMASLW 1155

  Fly   968 -SFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRK 1031
             |.|.|.||:..|.||..     .|.|..:.::...|..||:..|..|...||.    :|||.:.
Human  1156 SSCVVLPLLALTWMSAVL-----AMTDRRSVLFQALFAVFNSAQGFVITAVHCF----LRREVQD 1211

  Fly  1032 YVRQHAWLPKC---------------------------------LRCSKTSISSGIVTGNGPT-A 1062
            .|       ||                                 |.| :|.:...:.|.|..| .
Human  1212 VV-------KCQMGVCRADESEDSPDSCKNGQLQILSDFEKDVDLAC-QTVLFKEVNTCNPSTIT 1268

  Fly  1063 GTL--CSVSTSKKPK--------------------LPLGVSEEAHDDPQQQQQTPV--------- 1096
            |||  .|:...::||                    :|:..|....:.|..|:..||
Human  1269 GTLSRLSLDEDEEPKSCLVGPEGSLSFSPLPGNILVPMAASPGLGEPPPPQEANPVYMCGEGGLR 1333

  Fly  1097 -----------PITEDAIM-----------------GATSDCELNEAQQRRTLK----------- 1122
                       |.:|...|                 |..:.....|...||..|
Human  1334 QLDLTWLRPTEPGSEGDYMVLPRRTLSLQPGGGGGGGEDAPRARPEGTPRRAAKTVAHTEGYPSF 1398

  Fly  1123 -----SGLMTG------------TLQAPPQTLGGHVVLERGSTLRSTGHASP--TSSAGS----- 1163
                 |||..|            |.|.||.|.....|.|.|...|:.....|  |...||
Human  1399 LSVDHSGLGLGPAYGSLQNPYGMTFQPPPPTPSARQVPEPGERSRTMPRTVPGSTMKMGSLERKK 1463

  Fly  1164 ---THLIF---AHKQQQQQQQQGPLGESYYHQPDYYSWKQPSTGTGGLKTPREYYNNAGAAASSP 1222
               :.|.|   .|.:::..:....|.:. :|..|.|  :..||.    |..:.:..::|.||
Human  1464 LRYSDLDFEKVMHTRKRHSELYHELNQK-FHTFDRY--RSQSTA----KREKRWSVSSGGAA--- 1518

  Fly  1223 QQAHEVFYWTQKPNSGHNGK-------------KKRGAGGVPASPSGSLHSRTAAASQVLFYPSY 1274
                |....|.||:.|....             |....|.:|..|...|....|||        :
Human  1519 ----ERSVCTDKPSPGERPSLSQHRRHQSWSTFKSMTLGSLPPKPRERLTLHRAAA--------W 1571

  Fly  1275 KKTKPGQPTG 1284
            :.|:|  |.|
Human  1572 EPTEP--PDG 1579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Rha_Lectin_dCirl	22..113	CDD:438687	16/89 (18%)
		GAIN	451..682	CDD:465137	50/260 (19%)
		GPS	705..752	CDD:197639	17/51 (33%)
		7tmB2_CELSR_Adhesion_IV	763..1035	CDD:320557	83/312 (27%)
		TM helix 1	765..790	CDD:320557	8/24 (33%)
		TM helix 2	801..823	CDD:320557	7/21 (33%)
		TM helix 3	832..859	CDD:320557	10/26 (38%)
		TM helix 4	875..895	CDD:320557	9/20 (45%)
		TM helix 5	913..942	CDD:320557	9/28 (32%)
		TM helix 6	960..987	CDD:320557	10/60 (17%)
		TM helix 7	997..1022	CDD:320557	7/24 (29%)
		Herpes_TAF50	<1219..1365	CDD:308764	18/79 (23%)
ADGRB2	NP_001351786.1	AGRB_N	38..230	CDD:465991	16/93 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	229..271		14/41 (34%)
		TSP1	314..362	CDD:214559	6/47 (13%)
		TSP1	367..417	CDD:214559	10/56 (18%)
		TSP1	422..472	CDD:214559	13/67 (19%)
		TSP1	478..528	CDD:214559	10/54 (19%)
		HormR	531..595	CDD:214468	13/68 (19%)
		GAIN	614..>769	CDD:465137	35/171 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	767..806		9/48 (19%)
		GPS	870..923	CDD:197639	17/56 (30%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	874..924		15/53 (28%)
		7tmB2_BAI2	929..1219	CDD:320654	85/323 (26%)
		TM helix 1	931..956	CDD:320654	8/28 (29%)
		TM helix 2	966..988	CDD:320654	7/21 (33%)
		TM helix 3	997..1025	CDD:320654	10/27 (37%)
		TM helix 4	1035..1055	CDD:320654	8/19 (42%)
		TM helix 5	1073..1102	CDD:320654	10/33 (30%)
		TM helix 6	1149..1176	CDD:320654	8/31 (26%)
		TM helix 7	1181..1206	CDD:320654	7/28 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1359..1385		3/25 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1423..1454		9/30 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1498..1585		24/105 (23%)