DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and ADGRB1

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_016869180.1	Gene:	ADGRB1 / 575	HGNCID:	943	Length:	1663	Species:	Homo sapiens

Alignment Length:	1238	Identity:	257/1238 - (20%)
Similarity:	418/1238 - (33%)	Gaps:	334/1238 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 SGSVVPGNGSV--VRTINNINLNAAGMSGGDDESKL-----------FCGPTHARNLYWNMTRVG 346
            |.||..|.||.  .|..:......|...|..||.:.           .|...:...:.|..|..|
Human   533 SCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDNFGAVIWKETPAG 597

  Fly   347 DVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHK 411
            :|....||..|.|:...||            |.|::                        .:|:
Human   598 EVAAVRCPRNATGLILRRC------------ELDEE------------------------GIAY- 625

  Fly   412 VNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQR---------DSSLISIANDMSEVTSSKT 467
                       |.|  |...:|.|:...|::|...:.         ...:..:...:.|::...|
Human   626 -----------WEP--PTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLVEISQDGT 677

  Fly   468 LYGGDMLVTTKIIQTVSE--KMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDL 530
            .|.||:|.|..:::.::|  :..:...| |...|....|:          ||||.|.....|.:.
Human   678 SYSGDLLSTIDVLRNMTEIFRRAYYSPT-PGDVQNFVQIL----------SNLLAEENRDKWEEA 731

  Fly   531 -----NPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPD 590
                 |.::..|:....   ::...|.:.|.    |...|...|::||:..|.... .:.:.||
Human   732 QLAGPNAKELFRLVEDF---VDVIGFRMKDL----RDAYQVTDNLVLSIHKLPASG-ATDISFP- 787

  Fly   591 SDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRL---ESILKPSYDHFDLKSSRSYVRNTAI 652
            ...|..:.|..::|.                   ||:   :|:........|  .:..:|..|.:
Human   788 MKGWRATGDWAKVPE-------------------DRVTVSKSVFSTGLTEAD--EASVFVVGTVL 831

  Fly   653 LSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLKTENVTNPTCVFWNYID- 716
            ..|.....|  :|:...:|||||||.:: |.....|..|:.:...|: ....||.||:.|:..|
Human   832 YRNLGSFLA--LQRNTTVLNSKVISVTV-KPPPRSLRTPLEIEFAHM-YNGTTNQTCILWDETDV 892

  Fly   717 ---------HAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMR----- 767
                     ..||..||.....:...:.|.|:.|:.||||..:          ..|.||.
Human   893 PSSSAPPQLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQL----------SADANMEKATLP 947

  Fly   768 -IFIYISIGI-CVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIF 830
             :.:.:..|: .:..:::.::.:.::.  :::|.|:.|..:..|.:::...|.|:|..||...:.
Human   948 SVTLIVGCGVSSLTLLMLVIIYVSVWR--YIRSERSVILINFCLSIISSNALILIGQTQTRNKVV 1010

  Fly   831 CGFITIFLHCAILSGTAWFCYEAFHSYSTLTS---DELLLEVDQTPKVNCYYLLSYGLSLSVVAI 892
            |..:..|||...||...|...||:.||..:|.   :.|:.:        .:..|.:||...||||
Human  1011 CTLVAAFLHFFFLSSFCWVLTEAWQSYMAVTGHLRNRLIRK--------RFLCLGWGLPALVVAI 1067

  Fly   893 SLVIDPST-YTQNDYCVLMEANALFYA-----------TFVIPVLVF--FVAAIGYTFLSWIIMC 943
            |:....:. |:..:||.|.....|.||           ..||.:|||  .|:..|.|...
Human  1068 SVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKK----- 1127

  Fly   944 RKSRTG----------LK------------TKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYL 986
            .|.|.|          ||            |.:.|..|.......|  |.|.||:..|.||..
Human  1128 LKERAGQPSPHPLGRALKCAECGVLSAADATSDATSNAMASLWSSC--VVLPLLALTWMSAVL-- 1188

  Fly   987 RGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYV------RQ---------- 1035
               .:.|..:.::...|..|::|.|..|.:.|||    :|||.:..|      ||
Human  1189 ---AVTDRRSALFQILFAVFDSLEGFVIVMVHCI----LRREVQDAVKCRVVDRQEEGNGDSGGS 1246

  Fly  1036 ----HAWLP---------KCLRCSKTSISSGIVT---GNGPTAGTLCSVSTSKKPKLPLGVSEEA 1084
                ||.|.         .|....:....||.::   .|||     ||:.:.:..|     |..:
Human  1247 FQNGHAQLMTDFEKDVDLACRSGPEAVTGSGFLSCGEANGP-----CSLWSFRYLK-----STFS 1301

  Fly  1085 HDDPQQQQQTPVPITED-------AIMGATSDCELNEAQQRR------------TLKSGLMTGTL 1130
            .|.|.:...|...:.:|       .|.|......|.|.::.:            :|.:.:....|
Human  1302 RDSPGRGAGTAPVLNKDIAACRTATITGTLKRPSLPEEEKLKLAHAKGPPTNFNSLPANVSKLHL 1366

  Fly  1131 QAPPQTLGGHVVLERGSTLRSTGHASPTSS-AGSTHLIFAHKQQQQQQQQGPLGESYY------- 1187
            ...|:..||.:......:|......:|.|| .|...:......:..:.|:..|..||.
Human  1367 HGSPRYPGGPLPDFPNHSLTLKRDKAPKSSFVGDGDIFKKLDSELSRAQEKALDTSYVILPTATA 1431

  Fly  1188 -------HQPDY--YSWKQPSTGTGGLKTPREYYNNAGAAASSPQQAHEVFYWTQKPNSGHNGKK 1243
                   .:|.|  :..:.|.|....|.|..|    |...|.||.        :::|.||  |..
Human  1432 TLRPKPKEEPKYSIHIDQMPQTRLIHLSTAPE----ASLPARSPP--------SRQPPSG--GPP 1482

  Fly  1244 KRGAGGVPASPSGSLHSRTAAASQVLFYPSYKKT------KPGQPTGYPQYAEALDPPLATGNAA 1302
            :    ..||.|............|.|..|...:.      .||:|..:|  ..:..|.....|.|
Human  1483 E----APPAQPPPPPPPPPPPPQQPLPPPPNLEPAPPSLGDPGEPAAHP--GPSTGPSTKNENVA 1541

  Fly  1303 AYYQQQQQLRRQQ---------LHQQQQQQQQ-QQLSSD-EEQAEQHAHLLHLQRRAGSQQQLPA 1356
            .......:.|:.:         :|.:::.|.. |.|:.. :..||:...:|....:...:||.|.
Human  1542 TLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQDLNRKLQHAAEKDKEVLGPDSKQPEKQQTPN 1606

  Fly  1357 PPP 1359
            ..|
Human  1607 KRP 1609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	49/236 (21%)
		GPS	705..752	CDD:197639	17/56 (30%)
		7tm_4	763..1014	CDD:304433	70/296 (24%)
ADGRB1	XP_016869180.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010