DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cirl and ADGRB1

DIOPT Version :10

Sequence 1:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster
Sequence 2:XP_016869180.1 Gene:ADGRB1 / 575 HGNCID:943 Length:1663 Species:Homo sapiens


Alignment Length:1238 Identity:257/1238 - (20%)
Similarity:418/1238 - (33%) Gaps:334/1238 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   295 SGSVVPGNGSV--VRTINNINLNAAGMSGGDDESKL-----------FCGPTHARNLYWNMTRVG 346
            |.||..|.||.  .|..:......|...|..||.:.           .|...:...:.|..|..|
Human   533 SCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDNFGAVIWKETPAG 597

  Fly   347 DVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHK 411
            :|....||..|.|:...||            |.|::                        .:|: 
Human   598 EVAAVRCPRNATGLILRRC------------ELDEE------------------------GIAY- 625

  Fly   412 VNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQR---------DSSLISIANDMSEVTSSKT 467
                       |.|  |...:|.|:...|::|...:.         ...:..:...:.|::...|
Human   626 -----------WEP--PTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLVEISQDGT 677

  Fly   468 LYGGDMLVTTKIIQTVSE--KMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDL 530
            .|.||:|.|..:::.::|  :..:...| |...|....|:          ||||.|.....|.:.
Human   678 SYSGDLLSTIDVLRNMTEIFRRAYYSPT-PGDVQNFVQIL----------SNLLAEENRDKWEEA 731

  Fly   531 -----NPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPD 590
                 |.::..|:....   ::...|.:.|.    |...|...|::||:..|.... .:.:.|| 
Human   732 QLAGPNAKELFRLVEDF---VDVIGFRMKDL----RDAYQVTDNLVLSIHKLPASG-ATDISFP- 787

  Fly   591 SDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRL---ESILKPSYDHFDLKSSRSYVRNTAI 652
            ...|..:.|..::|.                   ||:   :|:........|  .:..:|..|.:
Human   788 MKGWRATGDWAKVPE-------------------DRVTVSKSVFSTGLTEAD--EASVFVVGTVL 831

  Fly   653 LSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLKTENVTNPTCVFWNYID- 716
            ..|.....|  :|:...:|||||||.:: |.....|..|:.:...|: ....||.||:.|:..| 
Human   832 YRNLGSFLA--LQRNTTVLNSKVISVTV-KPPPRSLRTPLEIEFAHM-YNGTTNQTCILWDETDV 892

  Fly   717 ---------HAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMR----- 767
                     ..||..||.....:...:.|.|:.|:.||||..:          ..|.||.     
Human   893 PSSSAPPQLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQL----------SADANMEKATLP 947

  Fly   768 -IFIYISIGI-CVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIF 830
             :.:.:..|: .:..:::.::.:.::.  :::|.|:.|..:..|.:::...|.|:|..||...:.
Human   948 SVTLIVGCGVSSLTLLMLVIIYVSVWR--YIRSERSVILINFCLSIISSNALILIGQTQTRNKVV 1010

  Fly   831 CGFITIFLHCAILSGTAWFCYEAFHSYSTLTS---DELLLEVDQTPKVNCYYLLSYGLSLSVVAI 892
            |..:..|||...||...|...||:.||..:|.   :.|:.:        .:..|.:||...||||
Human  1011 CTLVAAFLHFFFLSSFCWVLTEAWQSYMAVTGHLRNRLIRK--------RFLCLGWGLPALVVAI 1067

  Fly   893 SLVIDPST-YTQNDYCVLMEANALFYA-----------TFVIPVLVF--FVAAIGYTFLSWIIMC 943
            |:....:. |:..:||.|.....|.||           ..||.:|||  .|:..|.|...     
Human  1068 SVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKK----- 1127

  Fly   944 RKSRTG----------LK------------TKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYL 986
            .|.|.|          ||            |.:.|..|.......|  |.|.||:..|.||..  
Human  1128 LKERAGQPSPHPLGRALKCAECGVLSAADATSDATSNAMASLWSSC--VVLPLLALTWMSAVL-- 1188

  Fly   987 RGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYV------RQ---------- 1035
               .:.|..:.::...|..|::|.|..|.:.|||    :|||.:..|      ||          
Human  1189 ---AVTDRRSALFQILFAVFDSLEGFVIVMVHCI----LRREVQDAVKCRVVDRQEEGNGDSGGS 1246

  Fly  1036 ----HAWLP---------KCLRCSKTSISSGIVT---GNGPTAGTLCSVSTSKKPKLPLGVSEEA 1084
                ||.|.         .|....:....||.::   .|||     ||:.:.:..|     |..:
Human  1247 FQNGHAQLMTDFEKDVDLACRSGPEAVTGSGFLSCGEANGP-----CSLWSFRYLK-----STFS 1301

  Fly  1085 HDDPQQQQQTPVPITED-------AIMGATSDCELNEAQQRR------------TLKSGLMTGTL 1130
            .|.|.:...|...:.:|       .|.|......|.|.::.:            :|.:.:....|
Human  1302 RDSPGRGAGTAPVLNKDIAACRTATITGTLKRPSLPEEEKLKLAHAKGPPTNFNSLPANVSKLHL 1366

  Fly  1131 QAPPQTLGGHVVLERGSTLRSTGHASPTSS-AGSTHLIFAHKQQQQQQQQGPLGESYY------- 1187
            ...|:..||.:......:|......:|.|| .|...:......:..:.|:..|..||.       
Human  1367 HGSPRYPGGPLPDFPNHSLTLKRDKAPKSSFVGDGDIFKKLDSELSRAQEKALDTSYVILPTATA 1431

  Fly  1188 -------HQPDY--YSWKQPSTGTGGLKTPREYYNNAGAAASSPQQAHEVFYWTQKPNSGHNGKK 1243
                   .:|.|  :..:.|.|....|.|..|    |...|.||.        :::|.||  |..
Human  1432 TLRPKPKEEPKYSIHIDQMPQTRLIHLSTAPE----ASLPARSPP--------SRQPPSG--GPP 1482

  Fly  1244 KRGAGGVPASPSGSLHSRTAAASQVLFYPSYKKT------KPGQPTGYPQYAEALDPPLATGNAA 1302
            :    ..||.|............|.|..|...:.      .||:|..:|  ..:..|.....|.|
Human  1483 E----APPAQPPPPPPPPPPPPQQPLPPPPNLEPAPPSLGDPGEPAAHP--GPSTGPSTKNENVA 1541

  Fly  1303 AYYQQQQQLRRQQ---------LHQQQQQQQQ-QQLSSD-EEQAEQHAHLLHLQRRAGSQQQLPA 1356
            .......:.|:.:         :|.:::.|.. |.|:.. :..||:...:|....:...:||.|.
Human  1542 TLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQDLNRKLQHAAEKDKEVLGPDSKQPEKQQTPN 1606

  Fly  1357 PPP 1359
            ..|
Human  1607 KRP 1609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CirlNP_001260807.1 Gal_Rha_Lectin_dCirl 22..113 CDD:438687
GAIN 451..682 CDD:465137 49/240 (20%)
GPS 705..752 CDD:197639 17/56 (30%)
7tmB2_CELSR_Adhesion_IV 763..1035 CDD:320557 78/323 (24%)
TM helix 1 765..790 CDD:320557 3/31 (10%)
TM helix 2 801..823 CDD:320557 5/21 (24%)
TM helix 3 832..859 CDD:320557 10/26 (38%)
TM helix 4 875..895 CDD:320557 8/19 (42%)
TM helix 5 913..942 CDD:320557 11/41 (27%)
TM helix 6 960..987 CDD:320557 8/26 (31%)
TM helix 7 997..1022 CDD:320557 8/24 (33%)
Herpes_TAF50 <1219..1365 CDD:308764 32/158 (20%)
ADGRB1XP_016869180.1 TSP1 359..407 CDD:214559
TSP1 412..462 CDD:214559
TSP1 525..575 CDD:214559 11/41 (27%)
HormR 577..643 CDD:214468 20/115 (17%)
GAIN 661..859 CDD:465137 49/241 (20%)
GPS 880..938 CDD:197639 17/67 (25%)
7tmB2_BAI_Adhesion_VII 944..1234 CDD:320379 75/315 (24%)
TM helix 1 946..971 CDD:320379 1/24 (4%)
TM helix 2 981..1003 CDD:320379 5/21 (24%)
TM helix 3 1012..1040 CDD:320379 10/27 (37%)
TM helix 4 1050..1070 CDD:320379 8/27 (30%)
TM helix 5 1088..1117 CDD:320379 8/28 (29%)
TM helix 6 1164..1191 CDD:320379 9/33 (27%)
TM helix 7 1196..1221 CDD:320379 8/28 (29%)
AGRB_N 41..216 CDD:465991
TSP1 264..314 CDD:214559
Blue background indicates that the domain is not in the aligned region.

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