DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and ADGRG6

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_006715579.1	Gene:	ADGRG6 / 57211	HGNCID:	13841	Length:	1251	Species:	Homo sapiens

Alignment Length:	1025	Identity:	215/1025 - (20%)
Similarity:	351/1025 - (34%)	Gaps:	349/1025 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 SGTDDGTLL-TTKSSPNRPPGTAASGSVVP-------GNGSVVR---TINNI------------- 312
            |..|.|||. .|.:||:..|.|..:...|.       .:|.:.|   .|.||
Human   371 SCADLGTLCQATVNSPSTTPPTVTTNMPVTNRIDKQRNDGIIYRISVVIQNILRHPEVKVQSKVA 435

  Fly   313 --------NLN--------AAGMSGGDDESK----------------LFCGPTHARNLYWNM--- 342
                    |.|        :..:|.|:|:.|                |....|:..||...:
Human   436 EWLNSTFQNWNYTVYVVNISFHLSAGEDKIKVKRSLEDEPRLVLWALLVYNATNNTNLEGKIIQQ 500

  Fly   343 ------------TRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGY-------DEYDDDISSTTP 388
                        .|:..|||:..         ..|:.|:.  ..||       .||      ..|
Human   501 KLLKNNESLDEGLRLHTVNVRQL---------GHCLAMEE--PKGYYWPSIQPSEY------VLP 548

  Fly   389 AP------SGGDCLHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQ 447
            .|      :...|.:|:::  |.|:.              |.|.  |::.|..        ..|:
Human   549 CPDKPGFSASRICFYNATN--PLVTY--------------WGPV--DISNCLK--------EANE 587

  Fly   448 RDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVV 512
            ..:.::::..|...:||:.         .|.|::.|  |.:.:||...|......::....:.:.
Human   588 VANQILNLTADGQNLTSAN---------ITNIVEQV--KRIVNKEENIDITLGSTLMNIFSNILS 641

  Fly   513 KTGSNLLDES--------QLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKN 569
            .:.|:||:.|        :|:..:|||....:.:.|                           :|
Human   642 SSDSDLLESSSEALKTIDELAFKIDLNSTSHVNITT---------------------------RN 679

  Fly   570 ILLSVRVL--ETKTIQS-SVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESI- 630
            :.|||..|  .|..|.: |:..|.:::.....|            .|.|.|       |.|.|:
Human   680 LALSVSSLLPGTNAISNFSIGLPSNNESYFQMD------------FESGQV-------DPLASVI 725

  Fly   631 --------LKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQ 687
                    |.|.......::..::...|.:..        ::..:.:.|.|.|::.|:|......
Human   726 LPPNLLENLSPEDSVLVRRAQFTFFNKTGLFQ--------DVGPQRKTLVSYVMACSIGNITIQN 782

  Fly   688 LSQPITLTLKHLKTENVTNPTCVFW----NYIDHAWSANGC-SLESTNRTHSVCSCNHLTNFAIL 747
            |..|:.:.:||.:|:.|.:|.|.||    |.....|:.:|| :...::.:.:||.|||.|:|.:|
Human   783 LKDPVQIKIKHTRTQEVHHPICAFWDLNKNKSFGGWNTSGCVAHRDSDASETVCLCNHFTHFGVL 847

  Fly   748 MDV------VDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSAR---TSI 803
            ||:      :|.....:.|...       ||..||..:|....|||...|.    |..|   :.|
Human   848 MDLPRSASQLDARNTKVLTFIS-------YIGCGISAIFSAATLLTYVAFE----KLRRDYPSKI 901

  Fly   804 YTSIYLCLLAIELLFLLG--IEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELL 866
            ..::...||.:.|||||.  |........|..:.:.||..:|:...|...||.|.|..|.
Human   902 LMNLSTALLFLNLLFLLDGWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALV----- 961

  Fly   867 LEVDQTPKV-NCY---YLLSY-----GLSLSVVAISL-------VIDPSTYTQ---NDYCVLMEA 912
                   || |.|   |:|.:     ||...||::.|       |....:|.:   :::|.:.:.
Human   962 -------KVFNTYIRRYILKFCIIGWGLPALVVSVVLASRNNNEVYGKESYGKEKGDEFCWIQDP 1019

  Fly   913 NALFYAT--------FVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSF 969
             .:||.|        |.:.:.:|.|..:.       |..|..:...:|.....|.::|..:..:|
Human  1020 -VIFYVTCAGYFGVMFFLNIAMFIVVMVQ-------ICGRNGKRSNRTLREEVLRNLRSVVSLTF 1076

  Fly   970 VFLLLLSAVWCSAYFYLRGAKMDDDTADVYG-------YCFICFNTLLGLYIFVFHCIQNEKIRR 1027
                ||...|..|:|             .:|       |.|..||:|.||:||:|||...|.:::
Human  1077 ----LLGMTWGFAFF-------------AWGPLNIPFMYLFSIFNSLQGLFIFIFHCAMKENVQK 1124

  Fly  1028 EYRKYV--------RQHAW--------------LPKCLRCSKTSISSGIVTGNGPTAGTLC---- 1066
            ::|:::        ....|              |.|.|..|....:|..:|....::.|..
Human  1125 QWRQHLCCGRFRLADNSDWSKTATNIIKKSSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRN 1189

  Fly  1067 ----SVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMG---ATSD 1109
                |.|..|      .:|:.||.|..|....||....|.:.|   |.||
Human  1190 SHTDSASMDK------SLSKLAHADGDQTSIIPVHQVIDKVKGYCNAHSD 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	41/246 (17%)
		GPS	705..752	CDD:197639	18/57 (32%)
		7tm_4	763..1014	CDD:304433	69/289 (24%)
ADGRG6	XP_006715579.1	CUB	44..147	CDD:238001
		LamG	154..338	CDD:304605
		GPS	802..847	CDD:280071	15/44 (34%)
		7tm_4	864..1111	CDD:304433	70/294 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810