DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and adgre10

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_021333746.1	Gene:	adgre10 / 569655	ZFINID:	ZDB-GENE-090313-152	Length:	690	Species:	Danio rerio

Alignment Length:	787	Identity:	172/787 - (21%)
Similarity:	311/787 - (39%)	Gaps:	223/787 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 NVQP---CPGGAAGIAKWRCV---LMKRIPDSGYDEYDDDISSTTPAP---SGGDCLHNSSSCEP 404
            |.||   |....:....:|..   |...|||:..:.|    |..|.||   |||
Zfish    50 NSQPPIMCDASVSWSGWYRLFINGLSAHIPDTCVEVY----SCGTAAPLWISGG----------- 99

  Fly   405 PVSMAHKVNQRLRNFEPTWHPATPD--LTQ------CRSLWLN---NLEMRVNQRDSSLISIAND 458
                               |||..|  :|:      |....||   :::::....:.|:..:.:.
Zfish   100 -------------------HPAVEDGVVTRNVCSHWCGDCCLNGSFSIQVKACPGNYSVYELISP 145

  Fly   459 MSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAM--IMELLHCV------VKTG 515
            :  :.|:   |..|:..|.             :|...|...::.:  |:||:..:      :.|.
Zfish   146 L--ICSA---YCADVHTTL-------------EEACTDWTAKDCLVNILELIENITVQVLPLNTV 192

  Fly   516 SNLLD-----------------ESQLSSWLDLNPEDQMRVATSL--LTGLEYNAFLLADTIIRER 561
            :|.||                 .::|:|:.:...|...::.::|  ||....|.....:.:  |.
Zfish   193 TNYLDMVLEATEKFLVSSSSDSPAELASYGNRVLESTEKLISTLVKLTDTSANVSFTLENV--EG 255

  Fly   562 SVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDR 626
            .|.....|:.|: .:|:..|..|   |.|.|...::.:..:...||           :.|.::..
Zfish   256 HVFMVGPNVTLN-EILQLNTTNS---FMDIDLIGIAKNNKDTRSAA-----------VAFMSYTI 305

  Fly   627 LESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQP 691
            :|::||.  |.|:.:      :||.                 :.:.|.||||:|.|..:..|::|
Zfish   306 MENLLKA--DFFNTQ------KNTN-----------------KTMMSTVISATLPKTSNTALTKP 345

  Fly   692 ITLTLKHLKTENVTNP-TCVFWNYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILM------- 748
            :..|.:|::..:.:.. :||:||..:  |..:|||:.::|.:|:||||.||:.||::|
Zfish   346 VNFTFRHIREFDPSGSLSCVYWNISE--WIVDGCSVLNSNSSHTVCSCVHLSTFALIMQTSSSPP 408

  Fly   749 --DVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKL------FNGVFVKSARTSIYT 805
              |::|             :...:.:.:|:  ||..:|||:..|      .|.|    ||.:|..
Zfish   409 PSDLLD-------------LLNLVCVIVGL--VFFSLALLSFALCQWSPGVNNV----ARINICI 454

  Fly   806 SI----YLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELL 866
            |:    .|.||..:.|.|:..:|    :.|..|...||...||...|...||...:..:.:   |
Zfish   455 SLLSAHLLLLLTQQFLSLIRPQQ----VLCVVIAGLLHFLFLSAFVWMFIEAVLLFICVKN---L 512

  Fly   867 LEVDQTPK---VNCYY-LLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVF 927
            .:|....|   .|.:. ::.|.::|..|::|:.:.|..|......:.|:..  |:.:|:.||.|.
Zfish   513 SQVSSRKKEVLSNGFLCVIGYVVALIGVSVSIGMVPEGYGSEQCWIKMDKG--FFWSFLGPVCVI 575

  Fly   928 FVAAIGYTFLSWIIMCRKSRTGLK--TKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAK 990
                :|...:.:|.:.....:.||  ..|.::|...:..:..:....::|...|...:|    |.
Zfish   576 ----LGLNVILFISISIYLNSALKKLNAEVSQLKQTKVMVFKTLGQFVILGCPWILGFF----AH 632

  Fly   991 MDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIV 1055
            ::    .|....||..|:..|.:||:.:|:.:.:||::|:|       :..||.|       |..
Zfish   633 VN----MVVEIVFIIINSQQGTFIFLIYCVLSTEIRQQYKK-------IFTCLCC-------GCK 679

  Fly  1056 TGNGPTA 1062
            |.|..||
Zfish   680 TNNVNTA 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	45/253 (18%)
		GPS	705..752	CDD:197639	20/56 (36%)
		7tm_4	763..1014	CDD:304433	59/266 (22%)
adgre10	XP_021333746.1	GPS	360..406	CDD:197639	19/47 (40%)
		7tm_GPCRs	413..672	CDD:333717	67/305 (22%)
		TM helix 1	413..437	CDD:320095	7/38 (18%)
		TM helix 2	446..467	CDD:320095	8/24 (33%)
		TM helix 3	481..503	CDD:320095	7/21 (33%)
		TM helix 4	527..543	CDD:320095	3/15 (20%)
		TM helix 5	561..584	CDD:320095	6/28 (21%)
		TM helix 6	608..631	CDD:320095	3/26 (12%)
		TM helix 7	635..660	CDD:320095	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000